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Mapkap1 mitogen-activated protein kinase associated protein 1 [ Mus musculus (house mouse) ]

Gene ID: 227743, updated on 5-Aug-2018

Summary

Official Symbol
Mapkap1provided by MGI
Official Full Name
mitogen-activated protein kinase associated protein 1provided by MGI
Primary source
MGI:MGI:2444554
See related
Ensembl:ENSMUSG00000038696 Vega:OTTMUSG00000011942
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Sin1; AI591529; D230039K05Rik
Expression
Ubiquitous expression in CNS E18 (RPKM 15.7), CNS E14 (RPKM 14.9) and 28 other tissues See more
Orthologs

Genomic context

See Mapkap1 in Genome Data Viewer
Location:
2; 2 B
Exon count:
18
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 2 NC_000068.7 (34406771..34624958)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 2 NC_000068.6 (34287545..34480470)

Chromosome 2 - NC_000068.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA C230014O12 gene Neighboring gene pre B cell leukemia homeobox 3 Neighboring gene ribosomal protein S7 pseudogene Neighboring gene predicted gene, 34178 Neighboring gene ribosomal protein S3A pseudogene Neighboring gene predicted gene, 34372 Neighboring gene DnaJ (Hsp40) homolog, subfamily B, member 6 pseudogene Neighboring gene GTPase activating protein and VPS9 domains 1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
Ras GTPase binding ISO
Inferred from Sequence Orthology
more info
 
phosphatidic acid binding ISO
Inferred from Sequence Orthology
more info
 
phosphatidylinositol-3,4,5-trisphosphate binding ISO
Inferred from Sequence Orthology
more info
 
phosphatidylinositol-3,4-bisphosphate binding ISO
Inferred from Sequence Orthology
more info
 
phosphatidylinositol-3,5-bisphosphate binding ISO
Inferred from Sequence Orthology
more info
 
phosphatidylinositol-4,5-bisphosphate binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
phosphatidylinositol-4,5-bisphosphate binding ISO
Inferred from Sequence Orthology
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
TORC2 signaling IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
establishment or maintenance of actin cytoskeleton polarity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of Ras protein signal transduction ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
Golgi apparatus ISO
Inferred from Sequence Orthology
more info
 
TORC2 complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
 
cytosol ISO
Inferred from Sequence Orthology
more info
 
membrane IEA
Inferred from Electronic Annotation
more info
 
nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
nucleus IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
target of rapamycin complex 2 subunit MAPKAP1
Names
SAPK-interacting protein 1
TORC2 subunit MAPKAP1
mitogen-activated protein kinase 2-associated protein 1
stress-activated map kinase-interacting protein 1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001290625.1NP_001277554.1  target of rapamycin complex 2 subunit MAPKAP1 isoform a

    See identical proteins and their annotated locations for NP_001277554.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2, and 4 all encode the same isoform (a).
    Source sequence(s)
    AK132263, AL808102, AL845262, BC090644
    Consensus CDS
    CCDS15948.1
    UniProtKB/Swiss-Prot
    Q8BKH7
    Related
    ENSMUSP00000108751.1, ENSMUST00000113126.2
    Conserved Domains (3) summary
    cd13331
    Location:383490
    PH_Avo1; Avo1 Pleckstrin homology (PH) domain
    pfam05422
    Location:18129
    SIN1; Stress-activated map kinase interacting protein 1 (SIN1)
    pfam16978
    Location:139266
    CRIM; SAPK-interacting protein 1 (Sin1), middle CRIM domain
  2. NM_001290626.1NP_001277555.1  target of rapamycin complex 2 subunit MAPKAP1 isoform b

    See identical proteins and their annotated locations for NP_001277555.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an alternate exon and it thus differs in its 5' UTR, lacks a portion of the 5' coding region and initiates translation at a downstream in-frame start codon compared to variant 1. The encoded isoform (b) is shorter at the N-terminus compared to isoform a. Variants 3 and 5 both encode the same isoform (b).
    Source sequence(s)
    AK042154, AL845262, BB852269, BC090644
    Consensus CDS
    CCDS71035.1
    UniProtKB/Swiss-Prot
    Q8BKH7
    Related
    ENSMUSP00000123301.1, OTTMUSP00000012775, ENSMUST00000124443.7, OTTMUST00000028217
    Conserved Domains (2) summary
    cd13331
    Location:191298
    PH_Avo1; Avo1 Pleckstrin homology (PH) domain
    pfam16978
    Location:174
    CRIM; SAPK-interacting protein 1 (Sin1), middle CRIM domain
  3. NM_001362919.1NP_001349848.1  target of rapamycin complex 2 subunit MAPKAP1 isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1, 2, and 4 all encode the same isoform (a).
    Source sequence(s)
    AL808102, AL845262
    Conserved Domains (3) summary
    cd13331
    Location:383490
    PH_Avo1; Avo1 Pleckstrin homology (PH) domain
    pfam05422
    Location:18129
    SIN1; Stress-activated map kinase interacting protein 1 (SIN1)
    pfam16978
    Location:139266
    CRIM; SAPK-interacting protein 1 (Sin1), middle CRIM domain
  4. NM_001362920.1NP_001349849.1  target of rapamycin complex 2 subunit MAPKAP1 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR and coding sequence and initiates translation at a downstream in-frame start codon compared to variant 1. The encoded isoform (b) is shorter at the N-terminus compared to isoform a. Variants 3 and 5 both encode the same isoform (b).
    Source sequence(s)
    AL808102, AL845262
    Conserved Domains (2) summary
    cd13331
    Location:191298
    PH_Avo1; Avo1 Pleckstrin homology (PH) domain
    pfam16978
    Location:174
    CRIM; SAPK-interacting protein 1 (Sin1), middle CRIM domain
  5. NM_001362921.1NP_001349850.1  target of rapamycin complex 2 subunit MAPKAP1 isoform c

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (c) has the same N- and C-termini but is shorter compared to isoform a.
    Source sequence(s)
    AL808102, AL845262
    Conserved Domains (3) summary
    cd13331
    Location:347454
    PH_Avo1; Avo1 Pleckstrin homology (PH) domain
    pfam05422
    Location:18129
    SIN1; Stress-activated map kinase interacting protein 1 (SIN1)
    pfam16978
    Location:139266
    CRIM; SAPK-interacting protein 1 (Sin1), middle CRIM domain
  6. NM_177345.4NP_796319.1  target of rapamycin complex 2 subunit MAPKAP1 isoform a

    See identical proteins and their annotated locations for NP_796319.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (a). Variants 1, 2, and 4 all encode the same isoform (a).
    Source sequence(s)
    AK042154, AK052045, AL845262, BB852269, BC090644
    Consensus CDS
    CCDS15948.1
    UniProtKB/Swiss-Prot
    Q8BKH7
    Related
    ENSMUSP00000116494.1, OTTMUSP00000012773, ENSMUST00000147337.7, OTTMUST00000028215
    Conserved Domains (3) summary
    cd13331
    Location:383490
    PH_Avo1; Avo1 Pleckstrin homology (PH) domain
    pfam05422
    Location:18129
    SIN1; Stress-activated map kinase interacting protein 1 (SIN1)
    pfam16978
    Location:139266
    CRIM; SAPK-interacting protein 1 (Sin1), middle CRIM domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000068.7 Reference GRCm38.p4 C57BL/6J

    Range
    34406771..34624958
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017317443.1XP_017172932.1  target of rapamycin complex 2 subunit MAPKAP1 isoform X2

    UniProtKB/Swiss-Prot
    Q8BKH7
    Related
    ENSMUSP00000108749.1, OTTMUSP00000012776, ENSMUST00000113124.7, OTTMUST00000028218
    Conserved Domains (3) summary
    cd13331
    Location:347454
    PH_Avo1; Avo1 Pleckstrin homology (PH) domain
    pfam05422
    Location:18129
    SIN1; Stress-activated map kinase interacting protein 1 (SIN1)
    pfam16978
    Location:139266
    CRIM; SAPK-interacting protein 1 (Sin1), middle CRIM domain
  2. XM_017317446.1XP_017172935.1  target of rapamycin complex 2 subunit MAPKAP1 isoform X3

  3. XM_011239083.2XP_011237385.1  target of rapamycin complex 2 subunit MAPKAP1 isoform X1

    See identical proteins and their annotated locations for XP_011237385.1

    UniProtKB/Swiss-Prot
    Q8BKH7
    Conserved Domains (3) summary
    cd13331
    Location:383490
    PH_Avo1; Avo1 Pleckstrin homology (PH) domain
    pfam05422
    Location:18129
    SIN1; Stress-activated map kinase interacting protein 1 (SIN1)
    pfam16978
    Location:139266
    CRIM; SAPK-interacting protein 1 (Sin1), middle CRIM domain
  4. XM_011239084.2XP_011237386.1  target of rapamycin complex 2 subunit MAPKAP1 isoform X1

    See identical proteins and their annotated locations for XP_011237386.1

    UniProtKB/Swiss-Prot
    Q8BKH7
    Conserved Domains (3) summary
    cd13331
    Location:383490
    PH_Avo1; Avo1 Pleckstrin homology (PH) domain
    pfam05422
    Location:18129
    SIN1; Stress-activated map kinase interacting protein 1 (SIN1)
    pfam16978
    Location:139266
    CRIM; SAPK-interacting protein 1 (Sin1), middle CRIM domain
  5. XM_011239085.2XP_011237387.1  target of rapamycin complex 2 subunit MAPKAP1 isoform X5

    UniProtKB/Swiss-Prot
    Q8BKH7
    Related
    ENSMUSP00000108748.1, OTTMUSP00000012777, ENSMUST00000113123.7, OTTMUST00000028219
    Conserved Domains (2) summary
    cd13331
    Location:191298
    PH_Avo1; Avo1 Pleckstrin homology (PH) domain
    pfam16978
    Location:174
    CRIM; SAPK-interacting protein 1 (Sin1), middle CRIM domain
  6. XM_006497983.2XP_006498046.1  target of rapamycin complex 2 subunit MAPKAP1 isoform X5

    See identical proteins and their annotated locations for XP_006498046.1

    UniProtKB/Swiss-Prot
    Q8BKH7
    Conserved Domains (2) summary
    cd13331
    Location:191298
    PH_Avo1; Avo1 Pleckstrin homology (PH) domain
    pfam16978
    Location:174
    CRIM; SAPK-interacting protein 1 (Sin1), middle CRIM domain
  7. XM_006497982.2XP_006498045.1  target of rapamycin complex 2 subunit MAPKAP1 isoform X5

    UniProtKB/Swiss-Prot
    Q8BKH7
    Conserved Domains (2) summary
    cd13331
    Location:191298
    PH_Avo1; Avo1 Pleckstrin homology (PH) domain
    pfam16978
    Location:174
    CRIM; SAPK-interacting protein 1 (Sin1), middle CRIM domain
  8. XM_006497978.3XP_006498041.1  target of rapamycin complex 2 subunit MAPKAP1 isoform X2

    UniProtKB/Swiss-Prot
    Q8BKH7
    Conserved Domains (3) summary
    cd13331
    Location:347454
    PH_Avo1; Avo1 Pleckstrin homology (PH) domain
    pfam05422
    Location:18129
    SIN1; Stress-activated map kinase interacting protein 1 (SIN1)
    pfam16978
    Location:139266
    CRIM; SAPK-interacting protein 1 (Sin1), middle CRIM domain
  9. XM_006497980.3XP_006498043.1  target of rapamycin complex 2 subunit MAPKAP1 isoform X4

    Conserved Domains (3) summary
    cd13331
    Location:324431
    PH_Avo1; Avo1 Pleckstrin homology (PH) domain
    pfam05422
    Location:18129
    SIN1; Stress-activated map kinase interacting protein 1 (SIN1)
    pfam16978
    Location:139224
    CRIM; SAPK-interacting protein 1 (Sin1), middle CRIM domain
  10. XM_011239082.2XP_011237384.1  target of rapamycin complex 2 subunit MAPKAP1 isoform X1

    UniProtKB/Swiss-Prot
    Q8BKH7
    Conserved Domains (3) summary
    cd13331
    Location:383490
    PH_Avo1; Avo1 Pleckstrin homology (PH) domain
    pfam05422
    Location:18129
    SIN1; Stress-activated map kinase interacting protein 1 (SIN1)
    pfam16978
    Location:139266
    CRIM; SAPK-interacting protein 1 (Sin1), middle CRIM domain
  11. XM_006497975.2XP_006498038.1  target of rapamycin complex 2 subunit MAPKAP1 isoform X1

    See identical proteins and their annotated locations for XP_006498038.1

    UniProtKB/Swiss-Prot
    Q8BKH7
    Conserved Domains (3) summary
    cd13331
    Location:383490
    PH_Avo1; Avo1 Pleckstrin homology (PH) domain
    pfam05422
    Location:18129
    SIN1; Stress-activated map kinase interacting protein 1 (SIN1)
    pfam16978
    Location:139266
    CRIM; SAPK-interacting protein 1 (Sin1), middle CRIM domain
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