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Zic4 zinc finger protein of the cerebellum 4 [ Mus musculus (house mouse) ]

Gene ID: 22774, updated on 17-Jan-2023

Summary

Official Symbol
Zic4provided by MGI
Official Full Name
zinc finger protein of the cerebellum 4provided by MGI
Primary source
MGI:MGI:107201
See related
Ensembl:ENSMUSG00000036972 AllianceGenome:MGI:107201
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Enables RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in central nervous system development and regulation of transcription by RNA polymerase II. Located in nucleus. Is expressed in several structures, including central nervous system; embryo mesenchyme; future brain; genitourinary system; and retina. Used to study Dandy-Walker syndrome. Orthologous to human ZIC4 (Zic family member 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in whole brain E14.5 (RPKM 6.3), CNS E14 (RPKM 5.8) and 4 other tissues See more
Orthologs
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Genomic context

See Zic4 in Genome Data Viewer
Location:
9 E3.2; 9 48.26 cM
Exon count:
11
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (91247636..91271404)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (91365631..91389351)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA A730094K22 gene Neighboring gene methionyl aminopeptidase 1 pseudogene Neighboring gene predicted gene, 40546 Neighboring gene predicted gene, 40545 Neighboring gene zinc finger protein of the cerebellum 1 Neighboring gene predicted gene 29478 Neighboring gene predicted gene, 39400

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2)  1 citation
  • Endonuclease-mediated (3) 

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Process Evidence Code Pubs
involved_in central nervous system development IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
zinc finger protein ZIC 4
Names
Zic family member 4 (odd-paired homolog, Drosophila)

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001374749.1NP_001361678.1  zinc finger protein ZIC 4 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC116582
    Consensus CDS
    CCDS90639.1
    UniProtKB/Swiss-Prot
    Q8BG91
    Related
    ENSMUSP00000069568.6, ENSMUST00000066384.7
    Conserved Domains (3) summary
    COG5048
    Location:150295
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:185205
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam18366
    Location:129173
    zf_ZIC; Zic proteins zinc finger domain
  2. NM_009576.2NP_033602.2  zinc finger protein ZIC 4 isoform 2

    See identical proteins and their annotated locations for NP_033602.2

    Status: VALIDATED

    Source sequence(s)
    AC116582, AK028305, AK046913
    Consensus CDS
    CCDS23404.1
    UniProtKB/Swiss-Prot
    Q61467
    UniProtKB/TrEMBL
    A0A8C6HSB3, G3UYE7, Q8C8J4
    Related
    ENSMUSP00000134053.2, ENSMUST00000172646.8
    Conserved Domains (3) summary
    COG5048
    Location:143288
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:178198
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam18366
    Location:122166
    zf_ZIC; Zic proteins zinc finger domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    91247636..91271404
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036154852.1XP_036010745.1  zinc finger protein ZIC 4 isoform X7

    UniProtKB/TrEMBL
    A0A8C6HSB3, G3UYE7
    Conserved Domains (3) summary
    COG5048
    Location:143288
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:178198
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam18366
    Location:122166
    zf_ZIC; Zic proteins zinc finger domain
  2. XM_030244259.2XP_030100119.1  zinc finger protein ZIC 4 isoform X5

    Conserved Domains (3) summary
    COG5048
    Location:143288
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:178198
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam18366
    Location:122166
    zf_ZIC; Zic proteins zinc finger domain
  3. XM_036154848.1XP_036010741.1  zinc finger protein ZIC 4 isoform X3

    Conserved Domains (3) summary
    COG5048
    Location:200345
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:235255
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam18366
    Location:179223
    zf_ZIC; Zic proteins zinc finger domain
  4. XM_036154854.1XP_036010747.1  zinc finger protein ZIC 4 isoform X10

    Conserved Domains (2) summary
    COG5189
    Location:100160
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    sd00017
    Location:110132
    ZF_C2H2; C2H2 Zn finger [structural motif]
  5. XM_011242719.2XP_011241021.1  zinc finger protein ZIC 4 isoform X1

    Conserved Domains (3) summary
    COG5048
    Location:200345
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:235255
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam18366
    Location:179223
    zf_ZIC; Zic proteins zinc finger domain
  6. XM_030244262.2XP_030100122.1  zinc finger protein ZIC 4 isoform X7

    UniProtKB/TrEMBL
    A0A8C6HSB3, G3UYE7
    Conserved Domains (3) summary
    COG5048
    Location:143288
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:178198
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam18366
    Location:122166
    zf_ZIC; Zic proteins zinc finger domain
  7. XM_017313291.2XP_017168780.1  zinc finger protein ZIC 4 isoform X5

    Conserved Domains (3) summary
    COG5048
    Location:143288
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:178198
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam18366
    Location:122166
    zf_ZIC; Zic proteins zinc finger domain
  8. XM_036154851.1XP_036010744.1  zinc finger protein ZIC 4 isoform X5

    Conserved Domains (3) summary
    COG5048
    Location:143288
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:178198
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam18366
    Location:122166
    zf_ZIC; Zic proteins zinc finger domain
  9. XM_011242720.3XP_011241022.1  zinc finger protein ZIC 4 isoform X2

    Conserved Domains (3) summary
    COG5048
    Location:191336
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:226246
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam18366
    Location:170214
    zf_ZIC; Zic proteins zinc finger domain
  10. XM_030244265.1XP_030100125.1  zinc finger protein ZIC 4 isoform X7

    UniProtKB/TrEMBL
    A0A8C6HSB3, G3UYE7
    Conserved Domains (3) summary
    COG5048
    Location:143288
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:178198
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam18366
    Location:122166
    zf_ZIC; Zic proteins zinc finger domain
  11. XM_030244264.1XP_030100124.1  zinc finger protein ZIC 4 isoform X7

    UniProtKB/TrEMBL
    A0A8C6HSB3, G3UYE7
    Conserved Domains (3) summary
    COG5048
    Location:143288
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:178198
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam18366
    Location:122166
    zf_ZIC; Zic proteins zinc finger domain
  12. XM_030244266.1XP_030100126.1  zinc finger protein ZIC 4 isoform X7

    UniProtKB/TrEMBL
    A0A8C6HSB3, G3UYE7
    Conserved Domains (3) summary
    COG5048
    Location:143288
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:178198
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam18366
    Location:122166
    zf_ZIC; Zic proteins zinc finger domain
  13. XM_030244258.1XP_030100118.1  zinc finger protein ZIC 4 isoform X5

    Conserved Domains (3) summary
    COG5048
    Location:143288
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:178198
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam18366
    Location:122166
    zf_ZIC; Zic proteins zinc finger domain
  14. XM_006511078.4XP_006511141.1  zinc finger protein ZIC 4 isoform X5

    See identical proteins and their annotated locations for XP_006511141.1

    Conserved Domains (3) summary
    COG5048
    Location:143288
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:178198
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam18366
    Location:122166
    zf_ZIC; Zic proteins zinc finger domain
  15. XM_030244261.1XP_030100121.1  zinc finger protein ZIC 4 isoform X7

    UniProtKB/TrEMBL
    A0A8C6HSB3, G3UYE7
    Conserved Domains (3) summary
    COG5048
    Location:143288
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:178198
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam18366
    Location:122166
    zf_ZIC; Zic proteins zinc finger domain
  16. XM_030244274.1XP_030100134.1  zinc finger protein ZIC 4 isoform X11

    Conserved Domains (2) summary
    COG5189
    Location:2080
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    sd00017
    Location:3052
    ZF_C2H2; C2H2 Zn finger [structural motif]
  17. XM_036154849.1XP_036010742.1  zinc finger protein ZIC 4 isoform X5

    Conserved Domains (3) summary
    COG5048
    Location:143288
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:178198
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam18366
    Location:122166
    zf_ZIC; Zic proteins zinc finger domain
  18. XM_017313292.2XP_017168781.1  zinc finger protein ZIC 4 isoform X5

    Conserved Domains (3) summary
    COG5048
    Location:143288
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:178198
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam18366
    Location:122166
    zf_ZIC; Zic proteins zinc finger domain
  19. XM_011242723.3XP_011241025.1  zinc finger protein ZIC 4 isoform X5

    See identical proteins and their annotated locations for XP_011241025.1

    Conserved Domains (3) summary
    COG5048
    Location:143288
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:178198
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam18366
    Location:122166
    zf_ZIC; Zic proteins zinc finger domain
  20. XM_030244267.1XP_030100127.1  zinc finger protein ZIC 4 isoform X7

    UniProtKB/TrEMBL
    A0A8C6HSB3, G3UYE7
    Conserved Domains (3) summary
    COG5048
    Location:143288
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:178198
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam18366
    Location:122166
    zf_ZIC; Zic proteins zinc finger domain
  21. XM_036154850.1XP_036010743.1  zinc finger protein ZIC 4 isoform X5

    Conserved Domains (3) summary
    COG5048
    Location:143288
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:178198
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam18366
    Location:122166
    zf_ZIC; Zic proteins zinc finger domain
  22. XM_036154855.1XP_036010748.1  zinc finger protein ZIC 4 isoform X11

    Conserved Domains (2) summary
    COG5189
    Location:2080
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    sd00017
    Location:3052
    ZF_C2H2; C2H2 Zn finger [structural motif]
  23. XM_030244273.2XP_030100133.2  zinc finger protein ZIC 4 isoform X11

    Conserved Domains (2) summary
    COG5189
    Location:2080
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    sd00017
    Location:3052
    ZF_C2H2; C2H2 Zn finger [structural motif]
  24. XM_030244260.2XP_030100120.1  zinc finger protein ZIC 4 isoform X6

    Conserved Domains (3) summary
    COG5048
    Location:149294
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:184204
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam18366
    Location:128172
    zf_ZIC; Zic proteins zinc finger domain
  25. XM_030244268.1XP_030100128.1  zinc finger protein ZIC 4 isoform X7

    UniProtKB/TrEMBL
    A0A8C6HSB3, G3UYE7
    Conserved Domains (3) summary
    COG5048
    Location:143288
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:178198
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam18366
    Location:122166
    zf_ZIC; Zic proteins zinc finger domain
  26. XM_030244269.1XP_030100129.1  zinc finger protein ZIC 4 isoform X7

    UniProtKB/TrEMBL
    A0A8C6HSB3, G3UYE7
    Conserved Domains (3) summary
    COG5048
    Location:143288
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:178198
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam18366
    Location:122166
    zf_ZIC; Zic proteins zinc finger domain
  27. XM_011242722.3XP_011241024.1  zinc finger protein ZIC 4 isoform X4

    Conserved Domains (3) summary
    COG5048
    Location:149294
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:184204
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam18366
    Location:128172
    zf_ZIC; Zic proteins zinc finger domain
  28. XM_011242726.3XP_011241028.1  zinc finger protein ZIC 4 isoform X5

    See identical proteins and their annotated locations for XP_011241028.1

    Conserved Domains (3) summary
    COG5048
    Location:143288
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:178198
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam18366
    Location:122166
    zf_ZIC; Zic proteins zinc finger domain
  29. XM_011242725.1XP_011241027.1  zinc finger protein ZIC 4 isoform X5

    See identical proteins and their annotated locations for XP_011241027.1

    Conserved Domains (3) summary
    COG5048
    Location:143288
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:178198
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam18366
    Location:122166
    zf_ZIC; Zic proteins zinc finger domain
  30. XM_006511079.1XP_006511142.1  zinc finger protein ZIC 4 isoform X5

    See identical proteins and their annotated locations for XP_006511142.1

    Conserved Domains (3) summary
    COG5048
    Location:143288
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:178198
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam18366
    Location:122166
    zf_ZIC; Zic proteins zinc finger domain
  31. XM_030244263.1XP_030100123.1  zinc finger protein ZIC 4 isoform X7

    UniProtKB/TrEMBL
    A0A8C6HSB3, G3UYE7
    Conserved Domains (3) summary
    COG5048
    Location:143288
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:178198
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam18366
    Location:122166
    zf_ZIC; Zic proteins zinc finger domain
  32. XM_017313289.2XP_017168778.1  zinc finger protein ZIC 4 isoform X7

    UniProtKB/TrEMBL
    A0A8C6HSB3, G3UYE7
    Related
    ENSMUSP00000133958.2, ENSMUST00000173933.8
    Conserved Domains (3) summary
    COG5048
    Location:143288
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:178198
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam18366
    Location:122166
    zf_ZIC; Zic proteins zinc finger domain
  33. XM_006511067.4XP_006511130.1  zinc finger protein ZIC 4 isoform X5

    See identical proteins and their annotated locations for XP_006511130.1

    Conserved Domains (3) summary
    COG5048
    Location:143288
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:178198
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam18366
    Location:122166
    zf_ZIC; Zic proteins zinc finger domain
  34. XM_030244270.2XP_030100130.1  zinc finger protein ZIC 4 isoform X8

    Conserved Domains (3) summary
    COG5048
    Location:73218
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:108128
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam18366
    Location:5296
    zf_ZIC; Zic proteins zinc finger domain
  35. XM_036154853.1XP_036010746.1  zinc finger protein ZIC 4 isoform X9

    Conserved Domains (3) summary
    COG5048
    Location:73218
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:108128
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam18366
    Location:5296
    zf_ZIC; Zic proteins zinc finger domain