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Slc2a6 solute carrier family 2 (facilitated glucose transporter), member 6 [ Mus musculus (house mouse) ]

Gene ID: 227659, updated on 8-Feb-2024

Summary

Official Symbol
Slc2a6provided by MGI
Official Full Name
solute carrier family 2 (facilitated glucose transporter), member 6provided by MGI
Primary source
MGI:MGI:2443286
See related
Ensembl:ENSMUSG00000036067 AllianceGenome:MGI:2443286
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Glut6; Glut9; GLUT-6; A330096C23; F630103L12Rik
Summary
Predicted to enable transmembrane transporter activity. Involved in regulation of glycolytic process. Predicted to be located in lysosomal membrane. Orthologous to human SLC2A6 (solute carrier family 2 member 6). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in cerebellum adult (RPKM 12.1), spleen adult (RPKM 11.0) and 20 other tissues See more
Orthologs
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Genomic context

See Slc2a6 in Genome Data Viewer
Location:
2 A3; 2 19.18 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (26911375..26918011, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (27021363..27028000, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene predicted gene, 36649 Neighboring gene ADAM metallopeptidase with thrombospondin type 1 motif 13 Neighboring gene STARR-positive B cell enhancer ABC_E7799 Neighboring gene calcium channel flower domain containing 1 Neighboring gene STARR-positive B cell enhancer ABC_E5901 Neighboring gene STARR-positive B cell enhancer ABC_E7800 Neighboring gene STARR-seq mESC enhancer starr_03998 Neighboring gene ribosomal protein L6 pseudogene Neighboring gene predicted gene 13398

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 
  • Endonuclease-mediated (4)  1 citation

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within carbohydrate transport IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of glycolytic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of glycolytic process ISO
Inferred from Sequence Orthology
more info
 
involved_in transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in lysosomal membrane ISO
Inferred from Sequence Orthology
more info
 
located_in lysosome IEA
Inferred from Electronic Annotation
more info
 
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
solute carrier family 2, facilitated glucose transporter member 6
Names
glucose transporter type 6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001177627.1NP_001171098.1  solute carrier family 2, facilitated glucose transporter member 6 isoform 2

    See identical proteins and their annotated locations for NP_001171098.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an exon in the 3' coding region compared to variant 1. The resulting isoform (2) is shorter but has the same N- and C-termini compared to isoform 1.
    Source sequence(s)
    BC058210, BC141168, BY202464
    Consensus CDS
    CCDS50544.1
    UniProtKB/TrEMBL
    A2AR26
    Related
    ENSMUSP00000099954.5, ENSMUST00000102890.11
    Conserved Domains (2) summary
    cd06174
    Location:41415
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    pfam00083
    Location:40434
    Sugar_tr; Sugar (and other) transporter
  2. NM_172659.2NP_766247.2  solute carrier family 2, facilitated glucose transporter member 6 isoform 1

    See identical proteins and their annotated locations for NP_766247.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AK150104, BY202464
    Consensus CDS
    CCDS15822.1
    UniProtKB/Swiss-Prot
    A2AR26, Q3TLU5, Q3UDF0, Q8BTN2
    Related
    ENSMUSP00000049103.6, ENSMUST00000045702.6
    Conserved Domains (1) summary
    cl28910
    Location:38483
    MFS; Major Facilitator Superfamily

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    26911375..26918011 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006497917.5XP_006497980.1  solute carrier family 2, facilitated glucose transporter member 6 isoform X1

    Conserved Domains (1) summary
    cl28910
    Location:1385
    MFS; Major Facilitator Superfamily

RNA

  1. XR_374081.5 RNA Sequence