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Zfx zinc finger protein X-linked [ Mus musculus (house mouse) ]

Gene ID: 22764, updated on 6-Jun-2024

Summary

Official Symbol
Zfxprovided by MGI
Official Full Name
zinc finger protein X-linkedprovided by MGI
Primary source
MGI:MGI:99211
See related
Ensembl:ENSMUSG00000079509 AllianceGenome:MGI:99211
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Zfx5; Zfx6; Zfx5,6
Summary
Predicted to enable chromatin insulator sequence binding activity. Acts upstream of or within several processes, including gamete generation; ovarian follicle development; and parental behavior. Predicted to be located in nucleolus and nucleoplasm. Predicted to be active in chromosome. Is expressed in several structures, including 4-cell stage embryo; genitourinary system; ileum; liver; and spleen. Orthologous to several human genes including ZFX (zinc finger protein X-linked). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in placenta adult (RPKM 7.9), CNS E11.5 (RPKM 4.7) and 26 other tissues See more
Orthologs
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Genomic context

See Zfx in Genome Data Viewer
Location:
X C3; X 41.48 cM
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (93118237..93194250, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (94074631..94150645, complement)

Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene predicted gene 15165 Neighboring gene STARR-seq mESC enhancer starr_47553 Neighboring gene predicted pseudogene 6987 Neighboring gene STARR-seq mESC enhancer starr_47554 Neighboring gene STARR-seq mESC enhancer starr_47555 Neighboring gene predicted gene, 46691 Neighboring gene STARR-seq mESC enhancer starr_47557 Neighboring gene eukaryotic translation initiation factor 2, subunit 3, structural gene X-linked Neighboring gene STARR-seq mESC enhancer starr_47559 Neighboring gene STARR-positive B cell enhancer ABC_E8763 Neighboring gene kelch-like 15 Neighboring gene microRNA 7673

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables DNA-binding transcription activator activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables chromatin insulator sequence binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
part_of chromatin ISO
Inferred from Sequence Orthology
more info
 
is_active_in chromosome IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
zinc finger X-chromosomal protein
Names
X-linked zinc finger protein
zinc finger protein X-linked 5
zinc finger protein X-linked 6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001044386.1NP_001037851.1  zinc finger X-chromosomal protein isoform 1

    See identical proteins and their annotated locations for NP_001037851.1

    Status: VALIDATED

    Source sequence(s)
    AL626786, BF022794
    Consensus CDS
    CCDS30276.1
    UniProtKB/Swiss-Prot
    P17011, P17012, P23607
    UniProtKB/TrEMBL
    B1ASD1
    Related
    ENSMUSP00000085423.6, ENSMUST00000088102.12
    Conserved Domains (6) summary
    COG5048
    Location:537674
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:484504
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:713735
    zf-C2H2; Zinc finger, C2H2 type
    pfam04704
    Location:71404
    Zfx_Zfy_act; Zfx / Zfy transcription activation region
    pfam13465
    Location:727751
    zf-H2C2_2; Zinc-finger double domain
    cl19880
    Location:371451
    ROS_MUCR; ROS/MUCR transcriptional regulator protein
  2. NM_001358354.2NP_001345283.1  zinc finger X-chromosomal protein isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL626786
    UniProtKB/Swiss-Prot
    P23607
    UniProtKB/TrEMBL
    B7ZN32
    Conserved Domains (5) summary
    COG5048
    Location:487624
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:434454
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:663685
    zf-C2H2; Zinc finger, C2H2 type
    pfam04704
    Location:71354
    Zfx_Zfy_act; Zfx / Zfy transcription activation region
    pfam13465
    Location:677701
    zf-H2C2_2; Zinc-finger double domain
  3. NM_001358355.2NP_001345284.1  zinc finger X-chromosomal protein isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL626786
    UniProtKB/Swiss-Prot
    P23607
    UniProtKB/TrEMBL
    B7ZN32
    Conserved Domains (5) summary
    COG5048
    Location:487624
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:434454
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:663685
    zf-C2H2; Zinc finger, C2H2 type
    pfam04704
    Location:71354
    Zfx_Zfy_act; Zfx / Zfy transcription activation region
    pfam13465
    Location:677701
    zf-H2C2_2; Zinc-finger double domain
  4. NM_001358356.2NP_001345285.1  zinc finger X-chromosomal protein isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL626786
    Consensus CDS
    CCDS30276.1
    UniProtKB/Swiss-Prot
    P17011, P17012, P23607
    UniProtKB/TrEMBL
    B1ASD1
    Conserved Domains (6) summary
    COG5048
    Location:537674
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:484504
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:713735
    zf-C2H2; Zinc finger, C2H2 type
    pfam04704
    Location:71404
    Zfx_Zfy_act; Zfx / Zfy transcription activation region
    pfam13465
    Location:727751
    zf-H2C2_2; Zinc-finger double domain
    cl19880
    Location:371451
    ROS_MUCR; ROS/MUCR transcriptional regulator protein
  5. NM_001358357.1NP_001345286.1  zinc finger X-chromosomal protein isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL626786, BC028506
    Consensus CDS
    CCDS90734.1
    UniProtKB/TrEMBL
    B1ASD2, Q8R2L1
    Related
    ENSMUSP00000109558.2, ENSMUST00000113925.8
    Conserved Domains (1) summary
    pfam04704
    Location:71210
    Zfx_Zfy_act; Zfx / Zfy transcription activation region
  6. NM_001426089.1NP_001413018.1  zinc finger X-chromosomal protein isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL626786
    UniProtKB/Swiss-Prot
    P17011, P17012, P23607
    UniProtKB/TrEMBL
    B1ASD1
  7. NM_001426091.1NP_001413020.1  zinc finger X-chromosomal protein isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL626786
    UniProtKB/Swiss-Prot
    P23607
    UniProtKB/TrEMBL
    B7ZN32
  8. NM_001426092.1NP_001413021.1  zinc finger X-chromosomal protein isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL626786
    UniProtKB/Swiss-Prot
    P17011, P17012, P23607
    UniProtKB/TrEMBL
    B1ASD1
  9. NM_001426093.1NP_001413022.1  zinc finger X-chromosomal protein isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL626786
    UniProtKB/Swiss-Prot
    P17011, P17012, P23607
    UniProtKB/TrEMBL
    B1ASD1
  10. NM_001426094.1NP_001413023.1  zinc finger X-chromosomal protein isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL626786
    UniProtKB/Swiss-Prot
    P17011, P17012, P23607
    UniProtKB/TrEMBL
    B1ASD1
  11. NM_001426095.1NP_001413024.1  zinc finger X-chromosomal protein isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL626786
    UniProtKB/Swiss-Prot
    P17011, P17012, P23607
    UniProtKB/TrEMBL
    B1ASD1
    Related
    ENSMUSP00000109559.2, ENSMUST00000113926.8
  12. NM_001426096.1NP_001413025.1  zinc finger X-chromosomal protein isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL626786
    UniProtKB/Swiss-Prot
    P17011, P17012, P23607
    UniProtKB/TrEMBL
    B1ASD1
  13. NM_001426097.1NP_001413026.1  zinc finger X-chromosomal protein isoform 4

    Status: VALIDATED

    Source sequence(s)
    AL626786
    UniProtKB/Swiss-Prot
    P23607
  14. NM_001426098.1NP_001413027.1  zinc finger X-chromosomal protein isoform 4

    Status: VALIDATED

    Source sequence(s)
    AL626786
    UniProtKB/Swiss-Prot
    P23607
  15. NM_001426099.1NP_001413028.1  zinc finger X-chromosomal protein isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL626786
    UniProtKB/Swiss-Prot
    P23607
    UniProtKB/TrEMBL
    B7ZN32
  16. NM_001426100.1NP_001413029.1  zinc finger X-chromosomal protein isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL626786
    UniProtKB/Swiss-Prot
    P23607
    UniProtKB/TrEMBL
    B7ZN32
  17. NM_001426101.1NP_001413030.1  zinc finger X-chromosomal protein isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL626786
    UniProtKB/Swiss-Prot
    P23607
    UniProtKB/TrEMBL
    B7ZN32
  18. NM_001426102.1NP_001413031.1  zinc finger X-chromosomal protein isoform 5

    Status: VALIDATED

    Source sequence(s)
    AL626786
    UniProtKB/Swiss-Prot
    P23607
  19. NM_001426103.1NP_001413032.1  zinc finger X-chromosomal protein isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL626786
    UniProtKB/Swiss-Prot
    P17011, P17012, P23607
    UniProtKB/TrEMBL
    B1ASD1
  20. NM_001426104.1NP_001413033.1  zinc finger X-chromosomal protein isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL626786
    UniProtKB/TrEMBL
    B1ASD2, Q8R2L1
  21. NM_001426105.1NP_001413034.1  zinc finger X-chromosomal protein isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL626786
    UniProtKB/TrEMBL
    B1ASD2, Q8R2L1
  22. NM_001426106.1NP_001413035.1  zinc finger X-chromosomal protein isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL626786
    UniProtKB/TrEMBL
    B1ASD2, Q8R2L1
  23. NM_001426107.1NP_001413036.1  zinc finger X-chromosomal protein isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL626786
    UniProtKB/TrEMBL
    B1ASD2, Q8R2L1
  24. NM_001426108.1NP_001413037.1  zinc finger X-chromosomal protein isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL626786
    UniProtKB/TrEMBL
    B1ASD2, Q8R2L1
  25. NM_001426109.1NP_001413038.1  zinc finger X-chromosomal protein isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL626786
    UniProtKB/TrEMBL
    B1ASD2, Q8R2L1
  26. NM_011768.2NP_035898.2  zinc finger X-chromosomal protein isoform 1

    See identical proteins and their annotated locations for NP_035898.2

    Status: VALIDATED

    Source sequence(s)
    AL626786, BF022794
    Consensus CDS
    CCDS30276.1
    UniProtKB/Swiss-Prot
    P17011, P17012, P23607
    UniProtKB/TrEMBL
    B1ASD1
    Related
    ENSMUSP00000109560.2, ENSMUST00000113927.8
    Conserved Domains (6) summary
    COG5048
    Location:537674
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:484504
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:713735
    zf-C2H2; Zinc finger, C2H2 type
    pfam04704
    Location:71404
    Zfx_Zfy_act; Zfx / Zfy transcription activation region
    pfam13465
    Location:727751
    zf-H2C2_2; Zinc-finger double domain
    cl19880
    Location:371451
    ROS_MUCR; ROS/MUCR transcriptional regulator protein

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000086.8 Reference GRCm39 C57BL/6J

    Range
    93118237..93194250 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006527967.4XP_006528030.1  zinc finger X-chromosomal protein isoform X3

    UniProtKB/Swiss-Prot
    P23607
    Conserved Domains (5) summary
    COG5048
    Location:520644
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:467487
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:696718
    zf-C2H2; Zinc finger, C2H2 type
    pfam04704
    Location:104387
    Zfx_Zfy_act; Zfx / Zfy transcription activation region
    pfam13465
    Location:539563
    zf-H2C2_2; Zinc-finger double domain
  2. XM_006527965.4XP_006528028.1  zinc finger X-chromosomal protein isoform X1

    UniProtKB/Swiss-Prot
    P23607
    Conserved Domains (4) summary
    COG5048
    Location:570832
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:517537
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:452474
    zf-C2H2; Zinc finger, C2H2 type
    pfam04704
    Location:104437
    Zfx_Zfy_act; Zfx / Zfy transcription activation region