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FHL3 four and a half LIM domains 3 [ Homo sapiens (human) ]

Gene ID: 2275, updated on 9-Dec-2018

Summary

Official Symbol
FHL3provided by HGNC
Official Full Name
four and a half LIM domains 3provided by HGNC
Primary source
HGNC:HGNC:3704
See related
Ensembl:ENSG00000183386 MIM:602790
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SLIM2
Summary
The protein encoded by this gene is a member of a family of proteins containing a four-and-a-half LIM domain, which is a highly conserved double zinc finger motif. The encoded protein has been shown to interact with the cancer developmental regulators SMAD2, SMAD3, and SMAD4, the skeletal muscle myogenesis protein MyoD, and the high-affinity IgE beta chain regulator MZF-1. This protein may be involved in tumor suppression, repression of MyoD expression, and repression of IgE receptor expression. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]
Expression
Ubiquitous expression in esophagus (RPKM 21.3), endometrium (RPKM 16.8) and 25 other tissues See more
Orthologs

Genomic context

See FHL3 in Genome Data Viewer
Location:
1p34.3
Exon count:
8
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 1 NC_000001.11 (37996765..38005691, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (38462439..38471199, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene splicing factor 3a subunit 3 Neighboring gene RNA, U6 small nuclear 510, pseudogene Neighboring gene UTP11, small subunit processome component Neighboring gene translation initiation factor IF-2-like Neighboring gene POU class 3 homeobox 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of four and a half LIM domains 3 (FHL3) by siRNA inhibits HIV-1 replication in HeLa-derived TZM-bl cells PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC8696, MGC19547, MGC23614

Gene Ontology Provided by GOA

Function Evidence Code Pubs
actin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
actin cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
muscle organ development TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
Z disc IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
focal adhesion HDA PubMed 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
stress fiber IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
four and a half LIM domains protein 3
Names
FHL-3
LIM-only protein FHL3
SLIM-2
skeletal muscle LIM-protein 2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001243878.1NP_001230807.1  four and a half LIM domains protein 3 isoform 2

    See identical proteins and their annotated locations for NP_001230807.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (2) is shorter at the N-terminus compared to isoform 1.
    Source sequence(s)
    AK290641, BC001351, BC014501
    UniProtKB/Swiss-Prot
    Q13643
    UniProtKB/TrEMBL
    Q96C98
    Conserved Domains (3) summary
    cd09346
    Location:54105
    LIM3_FHL; The third LIM domain of Four and a half LIM domains protein (FHL)
    cd09434
    Location:113168
    LIM4_FHL3; The fourth LIM domain of Four and a half LIM domains protein 3 (FHL3)
    cl02475
    Location:147
    LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
  2. NM_004468.5NP_004459.2  four and a half LIM domains protein 3 isoform 1

    See identical proteins and their annotated locations for NP_004459.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AL603790
    Consensus CDS
    CCDS30678.1
    UniProtKB/Swiss-Prot
    Q13643
    Related
    ENSP00000362107.3, ENST00000373016.3
    Conserved Domains (5) summary
    cd09346
    Location:162213
    LIM3_FHL; The third LIM domain of Four and a half LIM domains protein (FHL)
    cd09423
    Location:3694
    LIM1_FHL3; The first LIM domain of Four and a half LIM domains protein 3 (FHL3)
    cd09427
    Location:98155
    LIM2_FHL3; The second LIM domain of Four and a half LIM domains protein 3 (FHL3)
    cd09434
    Location:221276
    LIM4_FHL3; The fourth LIM domain of Four and a half LIM domains protein 3 (FHL3)
    cl02475
    Location:533
    LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p12 Primary Assembly

    Range
    37996765..38005691 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017000675.1XP_016856164.1  four and a half LIM domains protein 3 isoform X2

  2. XM_024454101.1XP_024309869.1  four and a half LIM domains protein 3 isoform X1

    Conserved Domains (5) summary
    cd09346
    Location:162213
    LIM3_FHL; The third LIM domain of Four and a half LIM domains protein (FHL)
    cd09423
    Location:3694
    LIM1_FHL3; The first LIM domain of Four and a half LIM domains protein 3 (FHL3)
    cd09427
    Location:98155
    LIM2_FHL3; The second LIM domain of Four and a half LIM domains protein 3 (FHL3)
    cd09434
    Location:221276
    LIM4_FHL3; The fourth LIM domain of Four and a half LIM domains protein 3 (FHL3)
    cl02475
    Location:533
    LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
  3. XM_024454099.1XP_024309867.1  four and a half LIM domains protein 3 isoform X1

    Conserved Domains (5) summary
    cd09346
    Location:162213
    LIM3_FHL; The third LIM domain of Four and a half LIM domains protein (FHL)
    cd09423
    Location:3694
    LIM1_FHL3; The first LIM domain of Four and a half LIM domains protein 3 (FHL3)
    cd09427
    Location:98155
    LIM2_FHL3; The second LIM domain of Four and a half LIM domains protein 3 (FHL3)
    cd09434
    Location:221276
    LIM4_FHL3; The fourth LIM domain of Four and a half LIM domains protein 3 (FHL3)
    cl02475
    Location:533
    LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
  4. XM_024454100.1XP_024309868.1  four and a half LIM domains protein 3 isoform X1

    Conserved Domains (5) summary
    cd09346
    Location:162213
    LIM3_FHL; The third LIM domain of Four and a half LIM domains protein (FHL)
    cd09423
    Location:3694
    LIM1_FHL3; The first LIM domain of Four and a half LIM domains protein 3 (FHL3)
    cd09427
    Location:98155
    LIM2_FHL3; The second LIM domain of Four and a half LIM domains protein 3 (FHL3)
    cd09434
    Location:221276
    LIM4_FHL3; The fourth LIM domain of Four and a half LIM domains protein 3 (FHL3)
    cl02475
    Location:533
    LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
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