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Relch RAB11 binding and LisH domain, coiled-coil and HEAT repeat containing [ Mus musculus (house mouse) ]

Gene ID: 227446, updated on 8-Jan-2023

Summary

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Official Symbol
Relchprovided by MGI
Official Full Name
RAB11 binding and LisH domain, coiled-coil and HEAT repeat containingprovided by MGI
Primary source
MGI:MGI:1922832
See related
Ensembl:ENSMUSG00000026319 AllianceGenome:MGI:1922832
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Kiaa1468; mKIAA1468; 6430401N10; 2310035C23Rik
Summary
Predicted to be involved in intracellular cholesterol transport. Predicted to act upstream of or within lipid transport. Located in recycling endosome. Is expressed in central nervous system and ganglia. Orthologous to human RELCH (RAB11 binding and LisH domain, coiled-coil and HEAT repeat containing). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E18 (RPKM 9.9), bladder adult (RPKM 8.3) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Relch in Genome Data Viewer
Location:
1 E2.1; 1
Exon count:
31
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (105591570..105682856)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (105663843..105755131)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene phosphatidylinositol glycan anchor biosynthesis, class N Neighboring gene 60S ribosomal protein L37a-like Neighboring gene ribosomal protein L7A pseudogene Neighboring gene predicted gene 10193 Neighboring gene tumor necrosis factor receptor superfamily, member 11a, NFKB activator

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The Rab11-binding protein RELCH/KIAA1468 controls intracellular cholesterol distribution. Sobajima T, et al. J Cell Biol, 2018 May 7. PMID 29514919, Free PMC Article
  2. Mechanisms and Consequences of Dopamine Depletion-Induced Attenuation of the Spinophilin/Neurofilament Medium Interaction. Hiday AC, et al. Neural Plast, 2017. PMID 28634551, Free PMC Article
  3. 140 mouse brain proteins identified by Ca2+-calmodulin affinity chromatography and tandem mass spectrometry. Berggård T, et al. J Proteome Res, 2006 Mar. PMID 16512683
  4. Tagging genes with cassette-exchange sites. Cobellis G, et al. Nucleic Acids Res, 2005 Mar 1. PMID 15741177, Free PMC Article
  5. Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2003 Aug 31. PMID 14621295

See all (23) citations in PubMed

See citations in PubMed for homologs of this gene provided by HomoloGene

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in intracellular cholesterol transport IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
involved_in intracellular cholesterol transport ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within lipid transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
located_in endosome IEA
Inferred from Electronic Annotation
more info
  
is_active_in recycling endosome IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
located_in recycling endosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in recycling endosome ISO
Inferred from Sequence Orthology
more info
  
is_active_in trans-Golgi network IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
located_in trans-Golgi network ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
RAB11-binding protein RELCH
Names
RAB11-binding protein containing LisH, coiled-coil, and HEAT repeats

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_029349.2 → NP_083625.1  RAB11-binding protein RELCH isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame segment in the 5' CDS, compared to variant 1. The resulting protein (isoform 2) is shorter when it is compared to isoform 1.
    Source sequence(s)
    AC101816, AC166354
    Consensus CDS
    CCDS48334.1
    UniProtKB/Swiss-Prot
    Q148V7
    UniProtKB/TrEMBL
    A0A087WSS1
    Related
    ENSMUSP00000141162.2, ENSMUST00000190501.7
    Conserved Domains (1) summary
    sd00044
    Location:495 → 527
    HEAT; HEAT repeat [structural motif]

  2. NM_173187.4 → NP_775279.2  RAB11-binding protein RELCH isoform 1

    See identical proteins and their annotated locations for NP_775279.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and it encodes the longer protein (isoform 1).
    Source sequence(s)
    AC101816, AC166354
    Consensus CDS
    CCDS15206.1
    UniProtKB/Swiss-Prot
    Q148V7
    UniProtKB/TrEMBL
    E9QM90
    Related
    ENSMUSP00000039178.7, ENSMUST00000039173.13
    Conserved Domains (1) summary
    sd00044
    Location:519 → 551
    HEAT; HEAT repeat [structural motif]

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    105591570..105682856
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006529501.4 → XP_006529564.1  RAB11-binding protein RELCH isoform X1

    Conserved Domains (1) summary
    sd00044
    Location:1012 → 1040
    HEAT; HEAT repeat [structural motif]

  2. XM_006529507.4 → XP_006529570.1  RAB11-binding protein RELCH isoform X11

    Conserved Domains (1) summary
    sd00044
    Location:1012 → 1040
    HEAT; HEAT repeat [structural motif]

  3. XM_006529502.4 → XP_006529565.1  RAB11-binding protein RELCH isoform X2

    Conserved Domains (1) summary
    sd00044
    Location:648 → 677
    HEAT; HEAT repeat [structural motif]

  4. XM_006529503.4 → XP_006529566.1  RAB11-binding protein RELCH isoform X3

    Conserved Domains (1) summary
    sd00044
    Location:1009 → 1037
    HEAT; HEAT repeat [structural motif]

  5. XM_006529504.4 → XP_006529567.1  RAB11-binding protein RELCH isoform X4

    Conserved Domains (1) summary
    sd00044
    Location:1008 → 1036
    HEAT; HEAT repeat [structural motif]

  6. XM_030253824.1 → XP_030109684.1  RAB11-binding protein RELCH isoform X12

    Conserved Domains (1) summary
    sd00044
    Location:519 → 551
    HEAT; HEAT repeat [structural motif]

  7. XM_006529505.4 → XP_006529568.1  RAB11-binding protein RELCH isoform X5

    UniProtKB/TrEMBL
    G3X9J4
    Related
    ENSMUSP00000083926.5, ENSMUST00000086721.10
    Conserved Domains (1) summary
    sd00044
    Location:519 → 551
    HEAT; HEAT repeat [structural motif]

  8. XM_036164603.1 → XP_036020496.1  RAB11-binding protein RELCH isoform X6

    Conserved Domains (1) summary
    sd00044
    Location:519 → 551
    HEAT; HEAT repeat [structural motif]

  9. XM_030253811.1 → XP_030109671.1  RAB11-binding protein RELCH isoform X7

    Conserved Domains (1) summary
    sd00044
    Location:519 → 551
    HEAT; HEAT repeat [structural motif]

  10. XM_036164608.1 → XP_036020501.1  RAB11-binding protein RELCH isoform X13

    Conserved Domains (1) summary
    sd00044
    Location:519 → 551
    HEAT; HEAT repeat [structural motif]

  11. XM_006529506.5 → XP_006529569.1  RAB11-binding protein RELCH isoform X8

    Conserved Domains (1) summary
    sd00044
    Location:988 → 1016
    HEAT; HEAT repeat [structural motif]

  12. XM_030253819.1 → XP_030109679.1  RAB11-binding protein RELCH isoform X9

    Conserved Domains (1) summary
    sd00044
    Location:495 → 527
    HEAT; HEAT repeat [structural motif]

  13. XM_036164606.1 → XP_036020499.1  RAB11-binding protein RELCH isoform X10

    Conserved Domains (1) summary
    sd00044
    Location:495 → 527
    HEAT; HEAT repeat [structural motif]

  14. XM_036164611.1 → XP_036020504.1  RAB11-binding protein RELCH isoform X16

    Conserved Domains (1) summary
    sd00044
    Location:133 → 165
    HEAT; HEAT repeat [structural motif]

  15. XM_036164609.1 → XP_036020502.1  RAB11-binding protein RELCH isoform X14

    Conserved Domains (1) summary
    sd00044
    Location:626 → 654
    HEAT; HEAT repeat [structural motif]

  16. XM_036164610.1 → XP_036020503.1  RAB11-binding protein RELCH isoform X15

    Conserved Domains (1) summary
    sd00044
    Location:133 → 165
    HEAT; HEAT repeat [structural motif]

RNA

  1. XR_001784195.2 RNA Sequence

  2. XR_001784196.2 RNA Sequence

  3. XR_001784197.3 RNA Sequence

  4. XR_004942063.1 RNA Sequence

  5. XR_001784198.3 RNA Sequence

  6. XR_387169.4 RNA Sequence

    Related
    ENSMUST00000186807.7
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q148V7.1 GenPept UniProtKB/Swiss-Prot:Q148V7

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