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Ndufs1 NADH:ubiquinone oxidoreductase core subunit S1 [ Mus musculus (house mouse) ]

Gene ID: 227197, updated on 8-Jan-2023

Summary

Official Symbol
Ndufs1provided by MGI
Official Full Name
NADH:ubiquinone oxidoreductase core subunit S1provided by MGI
Primary source
MGI:MGI:2443241
See related
Ensembl:ENSMUSG00000025968 AllianceGenome:MGI:2443241
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
5830412M15Rik; 9930026A05Rik
Summary
Enables NADH dehydrogenase (ubiquinone) activity. Involved in mitochondrial respiratory chain complex I assembly. Located in mitochondrion. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; integumental system; and sensory organ. Human ortholog(s) of this gene implicated in inherited metabolic disorder; mitochondrial complex I deficiency; and nuclear type mitochondrial complex I deficiency 5. Orthologous to human NDUFS1 (NADH:ubiquinone oxidoreductase core subunit S1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in heart adult (RPKM 78.5), cerebellum adult (RPKM 29.7) and 22 other tissues See more
Orthologs
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Genomic context

See Ndufs1 in Genome Data Viewer
Location:
1; 1 C2
Exon count:
22
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (63182751..63215981, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (63143592..63176822, complement)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 24942 Neighboring gene INO80 complex subunit D Neighboring gene ribosomal protein S27, pseudogene 1 Neighboring gene INO80 complex subunit D, opposite strand Neighboring gene predicted gene, 26457 Neighboring gene small nucleolar RNA, H/ACA box 41 Neighboring gene eukaryotic translation elongation factor 1 beta 2

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (2) 
  • Endonuclease-mediated (1) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC7850, MGC19199

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 2 iron, 2 sulfur cluster binding IEA
Inferred from Electronic Annotation
more info
 
enables 4 iron, 4 sulfur cluster binding IEA
Inferred from Electronic Annotation
more info
 
enables NADH dehydrogenase (ubiquinone) activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
contributes_to NADH dehydrogenase (ubiquinone) activity ISO
Inferred from Sequence Orthology
more info
 
enables NADH dehydrogenase (ubiquinone) activity ISO
Inferred from Sequence Orthology
more info
 
enables electron transfer activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables iron-sulfur cluster binding IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
 
enables oxidoreductase activity, acting on NAD(P)H IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in mitochondrial inner membrane IEA
Inferred from Electronic Annotation
more info
 
located_in mitochondrial intermembrane space ISO
Inferred from Sequence Orthology
more info
 
part_of mitochondrial respiratory chain complex I ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrion HDA PubMed 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
 
located_in myelin sheath HDA PubMed 
located_in respirasome IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial
Names
CI-75kD
NADH dehydrogenase (ubiquinone) Fe-S protein 1
complex I-75kD
NP_001153510.1
NP_001153511.1
NP_001153512.1
NP_663493.2
XP_006496015.1
XP_030109554.1
XP_036020306.1
XP_036020310.1
XP_036020314.1
XP_036020318.1
XP_036020320.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001160038.1NP_001153510.1  NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial precursor

    See identical proteins and their annotated locations for NP_001153510.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. All four variants encode the same protein.
    Source sequence(s)
    AK036926, AV444601, BU708393, BY709888
    Consensus CDS
    CCDS14996.1
    UniProtKB/Swiss-Prot
    Q8BM16, Q91VD9
    Conserved Domains (1) summary
    PRK09130
    Location:31723
    PRK09130; NADH dehydrogenase subunit G; Validated
  2. NM_001160039.1NP_001153511.1  NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial precursor

    See identical proteins and their annotated locations for NP_001153511.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. All four variants encode the same protein.
    Source sequence(s)
    AK036926, AV444601, BY709888, CN715066
    Consensus CDS
    CCDS14996.1
    UniProtKB/Swiss-Prot
    Q8BM16, Q91VD9
    Conserved Domains (1) summary
    PRK09130
    Location:31723
    PRK09130; NADH dehydrogenase subunit G; Validated
  3. NM_001160040.1NP_001153512.1  NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial precursor

    See identical proteins and their annotated locations for NP_001153512.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. All four variants encode the same protein.
    Source sequence(s)
    AK036926, AV444601, BG808119, BY709888
    Consensus CDS
    CCDS14996.1
    UniProtKB/Swiss-Prot
    Q8BM16, Q91VD9
    Related
    ENSMUSP00000126621.3, ENSMUST00000168099.9
    Conserved Domains (1) summary
    PRK09130
    Location:31723
    PRK09130; NADH dehydrogenase subunit G; Validated
  4. NM_145518.2NP_663493.2  NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial precursor

    See identical proteins and their annotated locations for NP_663493.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. All four variants encode the same protein.
    Source sequence(s)
    AK036926, AV444601, BY709888
    Consensus CDS
    CCDS14996.1
    UniProtKB/Swiss-Prot
    Q8BM16, Q91VD9
    Related
    ENSMUSP00000027111.9, ENSMUST00000027111.15
    Conserved Domains (1) summary
    PRK09130
    Location:31723
    PRK09130; NADH dehydrogenase subunit G; Validated

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    63182751..63215981 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006495952.4XP_006496015.1  NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial isoform X1

    See identical proteins and their annotated locations for XP_006496015.1

    UniProtKB/Swiss-Prot
    Q8BM16, Q91VD9
    Conserved Domains (1) summary
    PRK09130
    Location:31723
    PRK09130; NADH dehydrogenase subunit G; Validated
  2. XM_036164427.1XP_036020320.1  NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial isoform X2

    Conserved Domains (1) summary
    PRK09130
    Location:1580
    PRK09130; NADH dehydrogenase subunit G; Validated
  3. XM_030253694.2XP_030109554.1  NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial isoform X1

    UniProtKB/Swiss-Prot
    Q8BM16
    Conserved Domains (1) summary
    PRK09130
    Location:31723
    PRK09130; NADH dehydrogenase subunit G; Validated
  4. XM_036164417.1XP_036020310.1  NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial isoform X1

    UniProtKB/Swiss-Prot
    Q8BM16
    Conserved Domains (1) summary
    PRK09130
    Location:31723
    PRK09130; NADH dehydrogenase subunit G; Validated
  5. XM_036164421.1XP_036020314.1  NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial isoform X1

    UniProtKB/Swiss-Prot
    Q8BM16
    Conserved Domains (1) summary
    PRK09130
    Location:31723
    PRK09130; NADH dehydrogenase subunit G; Validated
  6. XM_036164425.1XP_036020318.1  NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial isoform X2

    Conserved Domains (1) summary
    PRK09130
    Location:1580
    PRK09130; NADH dehydrogenase subunit G; Validated
  7. XM_036164413.1XP_036020306.1  NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial isoform X1

    UniProtKB/Swiss-Prot
    Q8BM16
    Conserved Domains (1) summary
    PRK09130
    Location:31723
    PRK09130; NADH dehydrogenase subunit G; Validated