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Ormdl1 ORM1-like 1 (S. cerevisiae) [ Mus musculus (house mouse) ]

Gene ID: 227102, updated on 10-Jun-2024

Summary

Official Symbol
Ormdl1provided by MGI
Official Full Name
ORM1-like 1 (S. cerevisiae)provided by MGI
Primary source
MGI:MGI:2181669
See related
Ensembl:ENSMUSG00000026097 AllianceGenome:MGI:2181669
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
C730042F17Rik
Summary
Predicted to be involved in cellular sphingolipid homeostasis; ceramide metabolic process; and negative regulation of ceramide biosynthetic process. Predicted to be located in endoplasmic reticulum membrane. Predicted to be part of SPOTS complex. Orthologous to human ORMDL1 (ORMDL sphingolipid biosynthesis regulator 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in bladder adult (RPKM 14.5), placenta adult (RPKM 13.3) and 28 other tissues See more
Orthologs
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Genomic context

See Ormdl1 in Genome Data Viewer
Location:
1 C1.1; 1 26.99 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (53336254..53349404)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (53297095..53310245)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 1700019A02 gene Neighboring gene STARR-seq mESC enhancer starr_00911 Neighboring gene PMS1 homolog 1, mismatch repair system component Neighboring gene predicted gene 28777 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:53370474-53370583 Neighboring gene O-sialoglycoprotein endopeptidase-like 1 Neighboring gene STARR-seq mESC enhancer starr_00913 Neighboring gene ankyrin and armadillo repeat containing pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E2543 Neighboring gene asparagine synthetase domain containing 1 Neighboring gene Asnsd1 upstream reading frame

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (2) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
 
Process Evidence Code Pubs
involved_in ceramide metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in ceramide metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in intracellular sphingolipid homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of motor behavior IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of myelination IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within negative regulation of ceramide biosynthetic process ISO
Inferred from Sequence Orthology
more info
PubMed 
acts_upstream_of regulation of ceramide biosynthetic process IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of regulation of sphingolipid biosynthetic process IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in sphingolipid biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of sphingomyelin biosynthetic process IGI
Inferred from Genetic Interaction
more info
PubMed 
Component Evidence Code Pubs
part_of SPOTS complex IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
located_in endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_145517.4NP_663492.3  ORM1-like protein 1

    See identical proteins and their annotated locations for NP_663492.3

    Status: VALIDATED

    Source sequence(s)
    AK077562, BF660823, CN705165, EL956043
    Consensus CDS
    CCDS14952.1
    UniProtKB/Swiss-Prot
    Q8BK13, Q921I0
    Related
    ENSMUSP00000027266.4, ENSMUST00000027266.4
    Conserved Domains (1) summary
    pfam04061
    Location:11146
    ORMDL; ORMDL family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    53336254..53349404
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)