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Slc9a2 solute carrier family 9 (sodium/hydrogen exchanger), member 2 [ Mus musculus (house mouse) ]

Gene ID: 226999, updated on 5-Jan-2023

Summary

Official Symbol
Slc9a2provided by MGI
Official Full Name
solute carrier family 9 (sodium/hydrogen exchanger), member 2provided by MGI
Primary source
MGI:MGI:105075
See related
Ensembl:ENSMUSG00000026062 AllianceGenome:MGI:105075
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
NHE2; 2210416H12Rik; 4932415O19Rik
Summary
Enables sodium:proton antiporter activity. Acts upstream of or within protein localization; regulation of pH; and sodium ion transport. Predicted to be located in brush border. Predicted to be active in plasma membrane. Is expressed in genitourinary system and skeleton. Orthologous to human SLC9A2 (solute carrier family 9 member A2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in colon adult (RPKM 88.7), small intestine adult (RPKM 52.2) and 5 other tissues See more
Orthologs
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Genomic context

See Slc9a2 in Genome Data Viewer
Location:
1 B; 1 19.66 cM
Exon count:
12
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (40720872..40808045)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (40681712..40768885)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 35801 Neighboring gene solute carrier family 9 (sodium/hydrogen exchanger), member 4 Neighboring gene predicted gene, 37435 Neighboring gene predicted gene, 37915 Neighboring gene major facilitator superfamily domain containing 9 Neighboring gene transmembrane protein 182

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1)  1 citation
  • Endonuclease-mediated (1) 

General gene information

Markers

Homology

Clone Names

  • MGC124408, MGC124410

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables potassium:proton antiporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables sodium:proton antiporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables sodium:proton antiporter activity IDA
Inferred from Direct Assay
more info
PubMed 
enables sodium:proton antiporter activity ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in brush border TAS
Traceable Author Statement
more info
PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
sodium/hydrogen exchanger 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001033289.2NP_001028461.2  sodium/hydrogen exchanger 2 precursor

    See identical proteins and their annotated locations for NP_001028461.2

    Status: PROVISIONAL

    Source sequence(s)
    BC103685
    Consensus CDS
    CCDS14914.1
    UniProtKB/TrEMBL
    A0A8C6I2H6, Q3ZAS0
    Related
    ENSMUSP00000027231.8, ENSMUST00000027231.13
    Conserved Domains (3) summary
    TIGR00840
    Location:75631
    b_cpa1; sodium/hydrogen exchanger 3
    pfam00999
    Location:85485
    Na_H_Exchanger; Sodium/hydrogen exchanger family
    pfam16644
    Location:579685
    NEXCaM_BD; Regulatory region of Na+/H+ exchanger NHE binds to calmodulin

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    40720872..40808045
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)