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Flvcr1 feline leukemia virus subgroup C cellular receptor 1 [ Mus musculus (house mouse) ]

Gene ID: 226844, updated on 12-May-2024

Summary

Official Symbol
Flvcr1provided by MGI
Official Full Name
feline leukemia virus subgroup C cellular receptor 1provided by MGI
Primary source
MGI:MGI:2444881
See related
Ensembl:ENSMUSG00000066595 AllianceGenome:MGI:2444881
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
FLVCR; Mfsd7b; 9630055N22Rik
Summary
Predicted to enable heme binding activity and heme transmembrane transporter activity. Acts upstream of or within several processes, including chordate embryonic development; embryonic digit morphogenesis; and hematopoietic or lymphoid organ development. Predicted to be located in plasma membrane. Predicted to be integral component of membrane. Predicted to be active in mitochondrion. Is expressed in ectoplacental cone; immune system; liver; placenta; and yolk sac. Used to study Diamond-Blackfan anemia. Orthologous to human FLVCR1 (FLVCR heme transporter 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in small intestine adult (RPKM 10.5), thymus adult (RPKM 9.2) and 28 other tissues See more
Orthologs
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Genomic context

See Flvcr1 in Genome Data Viewer
Location:
1 H6; 1 96.28 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (190738029..190758387, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (191005832..191026190, complement)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 31373 Neighboring gene ribosomal protein S15 pseudogene Neighboring gene RIKEN cDNA A230020J21 gene Neighboring gene STARR-positive B cell enhancer ABC_E223 Neighboring gene spermatogenesis associated 45 Neighboring gene TatD DNase domain containing 3 Neighboring gene STARR-positive B cell enhancer ABC_E4404 Neighboring gene NSL1, MIS12 kinetochore complex component

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (6) 
  • Targeted (4)  1 citation

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables heme binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables heme transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables heme transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
 
enables transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within blood vessel development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within embryonic digit morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within embryonic skeletal system morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in erythrocyte differentiation IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within erythrocyte differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within erythrocyte differentiation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within erythrocyte maturation IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within head morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in heme export IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in heme export ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within heme transport ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within in utero embryonic development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within limb morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in mitochondrial transport IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within mitochondrial transport ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within multicellular organism growth IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of organ growth IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within spleen development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
heme transporter FLVCR1
Names
feline leukemia virus subgroup C receptor-related protein 1
major facilitator superfamily domain containing 7B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001081259.1NP_001074728.1  heme transporter FLVCR1 isoform 1

    See identical proteins and their annotated locations for NP_001074728.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AK036315, AK044206, AV018812, BC157992, BY314941
    Consensus CDS
    CCDS35823.1
    UniProtKB/Swiss-Prot
    B2RXV4
    Related
    ENSMUSP00000082777.5, ENSMUST00000085635.6
    Conserved Domains (2) summary
    cd06174
    Location:104518
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    pfam07690
    Location:106483
    MFS_1; Major Facilitator Superfamily
  2. NM_001313747.1NP_001300676.1  heme transporter FLVCR1 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate exon in the 5' coding region and initiates translation at an alternate start codon compared to variant 1. The encoded isoform (2) has a distinct N-terminus and is shorter than isoform 1.
    Source sequence(s)
    AK036315, AK044206, AV018812, BC157992, BY314941
    UniProtKB/Swiss-Prot
    B2RXV4
    Conserved Domains (3) summary
    cd06174
    Location:192372
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    pfam07690
    Location:161337
    MFS_1; Major Facilitator Superfamily
    cl12078
    Location:7112
    p450; Cytochrome P450
  3. NM_198025.2NP_932142.2  heme transporter FLVCR1 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks multiple 3' coding exons and its transcription extends past a splice site used in variant 1, resulting in a different 3' coding region and 3' UTR. The encoded isoform (3) has a distinct C-terminus and is shorter than isoform 1.
    Source sequence(s)
    AC138229
    Consensus CDS
    CCDS83664.1
    UniProtKB/TrEMBL
    A0A0A6YWJ7, A0A0A6YXG8
    Related
    ENSMUSP00000141578.2, ENSMUST00000191946.2
    Conserved Domains (2) summary
    cd06174
    Location:104240
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    pfam07690
    Location:106240
    MFS_1; Major Facilitator Superfamily

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    190738029..190758387 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)