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FGL1 fibrinogen like 1 [ Homo sapiens (human) ]

Gene ID: 2267, updated on 1-Jun-2020

Summary

Official Symbol
FGL1provided by HGNC
Official Full Name
fibrinogen like 1provided by HGNC
Primary source
HGNC:HGNC:3695
See related
Ensembl:ENSG00000104760 MIM:605776
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HPS; HFREP1; HP-041; LFIRE1; LFIRE-1
Summary
Fibrinogen-like 1 is a member of the fibrinogen family. This protein is homologous to the carboxy terminus of the fibrinogen beta- and gamma- subunits which contains the four conserved cysteines of fibrinogens and fibrinogen related proteins. However, this protein lacks the platelet-binding site, cross-linking region and a thrombin-sensitive site which are necessary for fibrin clot formation. This protein may play a role in the development of hepatocellular carcinomas. Four alternatively spliced transcript variants encoding the same protein exist for this gene. [provided by RefSeq, Jul 2008]
Expression
Restricted expression toward liver (RPKM 275.4) See more
Orthologs

Genomic context

See FGL1 in Genome Data Viewer
Location:
8p22
Exon count:
11
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 8 NC_000008.11 (17864380..17909983, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (17721894..17767874, complement)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene microtubule associated scaffold protein 1 Neighboring gene RNA, 5S ribosomal pseudogene 256 Neighboring gene uncharacterized LOC101930275 Neighboring gene pericentriolar material 1 Neighboring gene uncharacterized LOC101929066 Neighboring gene N-acylsphingosine amidohydrolase 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC12455

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
signaling receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
adaptive immune response IEA
Inferred from Electronic Annotation
more info
 
hepatocyte proliferation IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of T cell activation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of T cell activation ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of immune response IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of immune response ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
collagen-containing extracellular matrix IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
extracellular region IDA
Inferred from Direct Assay
more info
PubMed 
extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
fibrinogen complex TAS
Traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
fibrinogen-like protein 1
Names
hepassocin
hepatocellular carcinoma-related sequence
hepatocyte-derived fibrinogen-related protein 1
liver fibrinogen-related protein 1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_004467.4NP_004458.3  fibrinogen-like protein 1 precursor

    See identical proteins and their annotated locations for NP_004458.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) appears to be the predominantly expressed transcript. It lacks an exon in the 5' UTR and has an alternate exon at the 5' end compared to the longest variant (4). All four variants encode the same protein.
    Source sequence(s)
    AC087273, AF042354, BG618053, D87342
    Consensus CDS
    CCDS6004.1
    UniProtKB/Swiss-Prot
    Q08830
    Related
    ENSP00000401952.1, ENST00000427924.5
    Conserved Domains (1) summary
    cd00087
    Location:78304
    FReD; Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular ...
  2. NM_147203.2NP_671736.2  fibrinogen-like protein 1 precursor

    See identical proteins and their annotated locations for NP_671736.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an exon in the 5' UTR compared to the longest variant (4). All four variants encode the same protein.
    Source sequence(s)
    AF042354, BC007047, BG567956
    Consensus CDS
    CCDS6004.1
    UniProtKB/Swiss-Prot
    Q08830
    Related
    ENSP00000371262.2, ENST00000381840.5
    Conserved Domains (1) summary
    cd00087
    Location:78304
    FReD; Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular ...
  3. NM_201552.1NP_963846.1  fibrinogen-like protein 1 precursor

    See identical proteins and their annotated locations for NP_963846.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) has an alternate exon at the 5' end compared to the longest variant (4). All four variants encode the same protein.
    Source sequence(s)
    AF042354, BC007047, BG566131, BG618053, D87342
    Consensus CDS
    CCDS6004.1
    UniProtKB/Swiss-Prot
    Q08830
    Related
    ENSP00000371263.2, ENST00000381841.4
    Conserved Domains (1) summary
    cd00087
    Location:78304
    FReD; Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular ...
  4. NM_201553.1NP_963847.1  fibrinogen-like protein 1 precursor

    See identical proteins and their annotated locations for NP_963847.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) represents the longest transcript. All four variants encode the same protein.
    Source sequence(s)
    AF042354, BG565379, BG567956, D87342
    Consensus CDS
    CCDS6004.1
    UniProtKB/Swiss-Prot
    Q08830
    Related
    ENSP00000381131.1, ENST00000398054.5
    Conserved Domains (1) summary
    cd00087
    Location:78304
    FReD; Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular ...

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p13 Primary Assembly

    Range
    17864380..17909983 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017013232.1XP_016868721.1  fibrinogen-like protein 1 isoform X1

    UniProtKB/Swiss-Prot
    Q08830
    Related
    ENSP00000381133.2, ENST00000398056.6
    Conserved Domains (1) summary
    cd00087
    Location:78304
    FReD; Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular ...
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