Atf6 activating transcription factor 6 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Atf6provided by MGI
Official Full Name: activating transcription factor 6provided by MGI
Primary source: MGI:MGI:1926157
See related: Ensembl:ENSMUSG00000026663 AllianceGenome:MGI:1926157
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: ESTM49; Atf6alpha; 9630036G24; 9130025P16Rik
Summary: Predicted to enable several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; protein heterodimerization activity; and ubiquitin protein ligase binding activity. Acts upstream of or within positive regulation of transcription by RNA polymerase II. Located in nucleus. Is expressed in several structures, including embryo mesenchyme; eye; liver; long bone; and tooth. Human ortholog(s) of this gene implicated in achromatopsia 7. Orthologous to human ATF6 (activating transcription factor 6). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in heart adult (RPKM 10.2), genital fat pad adult (RPKM 8.5) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 1 H3; 1 76.96 cM

Exon count:: 18

Annotation release	Status	Assembly	Chr	Location
109	current	GRCm39 (GCF_000001635.27)	1	NC_000067.7 (170532026..170696414, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	1	NC_000067.6 (170704457..170868585, complement)

Chromosome 1 - NC_000067.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

[Crosstalk between activating transcription factor 6 and the inositol-requiring enzyme 1-X-box binding protein 1 pathway in oxygen-glucose deprivation/reoxygenation-injured HT22 cells].
Title: [Crosstalk between activating transcription factor 6 and the inositol-requiring enzyme 1-X-box binding protein 1 pathway in oxygen-glucose deprivation/reoxygenation-injured HT22 cells].
ATF6alpha contributes to rheumatoid arthritis by inducing inflammatory cytokine production and apoptosis resistance.
Title: ATF6α contributes to rheumatoid arthritis by inducing inflammatory cytokine production and apoptosis resistance.
Scleral PERK and ATF6 as targets of myopic axial elongation of mouse eyes.
Title: Scleral PERK and ATF6 as targets of myopic axial elongation of mouse eyes.
MiR-195-5p represses inflammation, apoptosis, oxidative stress, and endoplasmic reticulum stress in sepsis-induced myocardial injury by targeting activating transcription factor 6.
Title: MiR-195-5p represses inflammation, apoptosis, oxidative stress, and endoplasmic reticulum stress in sepsis-induced myocardial injury by targeting activating transcription factor 6.
A permissive epigenetic landscape facilitates distinct transcriptional signatures of activating transcription factor 6 in the liver.
Title: A permissive epigenetic landscape facilitates distinct transcriptional signatures of activating transcription factor 6 in the liver.
ATF6 deficiency damages the development of spermatogenesis in male Atf6 knockout mice.
Title: ATF6 deficiency damages the development of spermatogenesis in male Atf6 knockout mice.
Downregulation of RIP3 Improves the Protective Effect of ATF6 in an Acute Liver Injury Model.
Title: Downregulation of RIP3 Improves the Protective Effect of ATF6 in an Acute Liver Injury Model.
ATF6 is required for efficient rhodopsin clearance and retinal homeostasis in the P23H rho retinitis pigmentosa mouse model.
Title: ATF6 is required for efficient rhodopsin clearance and retinal homeostasis in the P23H rho retinitis pigmentosa mouse model.
Coordinated signaling of activating transcription factor 6alpha and inositol-requiring enzyme 1alpha regulates hepatic stellate cell-mediated fibrogenesis in mice.
Title: Coordinated signaling of activating transcription factor 6α and inositol-requiring enzyme 1α regulates hepatic stellate cell-mediated fibrogenesis in mice.
MiR-149 attenuates endoplasmic reticulum stress-induced inflammation and apoptosis in nonalcoholic fatty liver disease by negatively targeting ATF6 pathway.
Title: MiR-149 attenuates endoplasmic reticulum stress-induced inflammation and apoptosis in nonalcoholic fatty liver disease by negatively targeting ATF6 pathway.

Submit: New GeneRIF Correction See all GeneRIFs (74)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (1) 1 citation
Targeted (3) 1 citation
Endonuclease-mediated (3) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AW061147 (e-PCR)
- UniSTS:178508

D1Mit270 (e-PCR), detects polymorphism
- UniSTS:128619

Atf6 (e-PCR), detects polymorphism
- UniSTS:496755

AI326426 (e-PCR)
- UniSTS:158884

AA789574 (e-PCR), detects polymorphism
- UniSTS:143035

Homology

Homologs of the Atf6 gene: The Atf6 gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, rat, chicken, zebrafish, and frog.
Orthologs from Annotation Pipeline: 494 organisms have orthologs with human gene Atf6
Orthologs

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription activator activity, RNA polymerase II-specific	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription factor activity	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables cAMP response element binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein heterodimerization activity	ISO Inferred from Sequence Orthology more info
enables sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables sequence-specific double-stranded DNA binding	ISO Inferred from Sequence Orthology more info
enables transcription cis-regulatory region binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in endoplasmic reticulum unfolded protein response	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in eye development	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of ATF6-mediated unfolded protein response	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of autophagy	ISO Inferred from Sequence Orthology more info	PubMed
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress	ISO Inferred from Sequence Orthology more info
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info	PubMed
acts_upstream_of_or_within response to unfolded protein	IEA Inferred from Electronic Annotation more info
involved_in visual perception	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
part_of RNA polymerase II transcription regulator complex	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum	NAS Non-traceable Author Statement more info	PubMed
located_in endoplasmic reticulum membrane	ISO Inferred from Sequence Orthology more info
located_in membrane	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	NAS Non-traceable Author Statement more info	PubMed

General protein information

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Preferred Names: cyclic AMP-dependent transcription factor ATF-6 alpha

Names: ATF6-alpha; activating transcription factor 6 alpha; cAMP-dependent transcription factor ATF-6 alpha

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001081304.1 → NP_001074773.1 cyclic AMP-dependent transcription factor ATF-6 alpha

See identical proteins and their annotated locations for NP_001074773.1

Status: VALIDATED

Source sequence(s)

AC113490, AC125021

Consensus CDS

CCDS56653.1

UniProtKB/Swiss-Prot

F6VAN0, Q8BZ84

Related

ENSMUSP00000027974.6, ENSMUST00000027974.7

Conserved Domains (2) summary

cd14700
Location:296 → 347

bZIP_ATF6; Basic leucine zipper (bZIP) domain of Activating Transcription Factor-6 (ATF-6) and similar proteins: a DNA-binding and dimerization domain

pfam05817
Location:223 → 298

Ribophorin_II; Oligosaccharyltransferase subunit Ribophorin II

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000067.7 Reference GRCm39 C57BL/6J

Range

170532026..170696414 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030253420.2 → XP_030109280.1 cyclic AMP-dependent transcription factor ATF-6 alpha isoform X1

UniProtKB/Swiss-Prot

Q8BZ84

Conserved Domains (2) summary

cd14700
Location:296 → 347

bZIP_ATF6; Basic leucine zipper (bZIP) domain of Activating Transcription Factor-6 (ATF-6) and similar proteins: a DNA-binding and dimerization domain

pfam05817
Location:223 → 298

Ribophorin_II; Oligosaccharyltransferase subunit Ribophorin II
XM_011238796.4 → XP_011237098.1 cyclic AMP-dependent transcription factor ATF-6 alpha isoform X2

Conserved Domains (2) summary

cd14700
Location:296 → 347

bZIP_ATF6; Basic leucine zipper (bZIP) domain of Activating Transcription Factor-6 (ATF-6) and similar proteins: a DNA-binding and dimerization domain

pfam05817
Location:223 → 298

Ribophorin_II; Oligosaccharyltransferase subunit Ribophorin II
XM_006496792.5 → XP_006496855.1 cyclic AMP-dependent transcription factor ATF-6 alpha isoform X3

Conserved Domains (2) summary

cd14700
Location:281 → 332

bZIP_ATF6; Basic leucine zipper (bZIP) domain of Activating Transcription Factor-6 (ATF-6) and similar proteins: a DNA-binding and dimerization domain

pfam05817
Location:208 → 283

Ribophorin_II; Oligosaccharyltransferase subunit Ribophorin II