U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Atf6 activating transcription factor 6 [ Mus musculus (house mouse) ]

Gene ID: 226641, updated on 16-Apr-2024

Summary

Official Symbol
Atf6provided by MGI
Official Full Name
activating transcription factor 6provided by MGI
Primary source
MGI:MGI:1926157
See related
Ensembl:ENSMUSG00000026663 AllianceGenome:MGI:1926157
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
ESTM49; Atf6alpha; 9630036G24; 9130025P16Rik
Summary
Predicted to enable several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; protein heterodimerization activity; and ubiquitin protein ligase binding activity. Acts upstream of or within positive regulation of transcription by RNA polymerase II. Located in nucleus. Is expressed in several structures, including embryo mesenchyme; eye; liver; long bone; and tooth. Human ortholog(s) of this gene implicated in achromatopsia 7. Orthologous to human ATF6 (activating transcription factor 6). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in heart adult (RPKM 10.2), genital fat pad adult (RPKM 8.5) and 28 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Atf6 in Genome Data Viewer
Location:
1 H3; 1 76.96 cM
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (170532026..170696414, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (170704457..170868585, complement)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_02995 Neighboring gene ribosomal protein L17 pseudogene Neighboring gene olfactomedin-like 2B Neighboring gene predicted gene, 23523 Neighboring gene predicted gene, 25235 Neighboring gene STARR-positive B cell enhancer ABC_E4381 Neighboring gene STARR-positive B cell enhancer ABC_E7774 Neighboring gene STARR-positive B cell enhancer ABC_E7775 Neighboring gene STARR-positive B cell enhancer ABC_E5842 Neighboring gene predicted gene, 29733 Neighboring gene STARR-seq mESC enhancer starr_02996 Neighboring gene predicted gene 9929 Neighboring gene STARR-seq mESC enhancer starr_02999 Neighboring gene STARR-positive B cell enhancer ABC_E7776 Neighboring gene STARR-positive B cell enhancer ABC_E5843 Neighboring gene dual specificity phosphatase 12 Neighboring gene STARR-positive B cell enhancer ABC_E11106 Neighboring gene STARR-positive B cell enhancer ABC_E4382 Neighboring gene STARR-positive B cell enhancer ABC_E4383 Neighboring gene Fc receptor-like B

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Component Evidence Code Pubs
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
 
part_of RNA polymerase II transcription regulator complex ISO
Inferred from Sequence Orthology
more info
 
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
located_in endoplasmic reticulum NAS
Non-traceable Author Statement
more info
PubMed 
located_in endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
 
located_in membrane ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus NAS
Non-traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
cyclic AMP-dependent transcription factor ATF-6 alpha
Names
ATF6-alpha
activating transcription factor 6 alpha
cAMP-dependent transcription factor ATF-6 alpha

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001081304.1NP_001074773.1  cyclic AMP-dependent transcription factor ATF-6 alpha

    See identical proteins and their annotated locations for NP_001074773.1

    Status: VALIDATED

    Source sequence(s)
    AC113490, AC125021
    Consensus CDS
    CCDS56653.1
    UniProtKB/Swiss-Prot
    B2RU98, F6VAN0, Q8BZ84
    UniProtKB/TrEMBL
    Q811K9
    Related
    ENSMUSP00000027974.6, ENSMUST00000027974.7
    Conserved Domains (2) summary
    cd14700
    Location:296347
    bZIP_ATF6; Basic leucine zipper (bZIP) domain of Activating Transcription Factor-6 (ATF-6) and similar proteins: a DNA-binding and dimerization domain
    pfam05817
    Location:223298
    Ribophorin_II; Oligosaccharyltransferase subunit Ribophorin II

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    170532026..170696414 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030253420.2XP_030109280.1  cyclic AMP-dependent transcription factor ATF-6 alpha isoform X1

    UniProtKB/Swiss-Prot
    B2RU98, F6VAN0, Q8BZ84
    UniProtKB/TrEMBL
    Q811K9
    Conserved Domains (2) summary
    cd14700
    Location:296347
    bZIP_ATF6; Basic leucine zipper (bZIP) domain of Activating Transcription Factor-6 (ATF-6) and similar proteins: a DNA-binding and dimerization domain
    pfam05817
    Location:223298
    Ribophorin_II; Oligosaccharyltransferase subunit Ribophorin II
  2. XM_011238796.4XP_011237098.1  cyclic AMP-dependent transcription factor ATF-6 alpha isoform X2

    UniProtKB/TrEMBL
    Q811K9
    Conserved Domains (2) summary
    cd14700
    Location:296347
    bZIP_ATF6; Basic leucine zipper (bZIP) domain of Activating Transcription Factor-6 (ATF-6) and similar proteins: a DNA-binding and dimerization domain
    pfam05817
    Location:223298
    Ribophorin_II; Oligosaccharyltransferase subunit Ribophorin II
  3. XM_006496792.5XP_006496855.1  cyclic AMP-dependent transcription factor ATF-6 alpha isoform X3

    UniProtKB/TrEMBL
    Q811K9
    Conserved Domains (2) summary
    cd14700
    Location:281332
    bZIP_ATF6; Basic leucine zipper (bZIP) domain of Activating Transcription Factor-6 (ATF-6) and similar proteins: a DNA-binding and dimerization domain
    pfam05817
    Location:208283
    Ribophorin_II; Oligosaccharyltransferase subunit Ribophorin II