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Rcsd1 RCSD domain containing 1 [ Mus musculus (house mouse) ]

Gene ID: 226594, updated on 8-Dec-2022

Summary

Official Symbol
Rcsd1provided by MGI
Official Full Name
RCSD domain containing 1provided by MGI
Primary source
MGI:MGI:2676394
See related
Ensembl:ENSMUSG00000040723 AllianceGenome:MGI:2676394
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
CapZIP; Gm19627; A430105K13Rik
Summary
Predicted to enable actin filament binding activity. Predicted to be involved in cellular hyperosmotic response and skeletal muscle contraction. Is expressed in several structures, including brain meninges; chondrocranium; gut; metanephros; and smooth muscle tissue. Orthologous to human RCSD1 (RCSD domain containing 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in thymus adult (RPKM 43.0), spleen adult (RPKM 17.7) and 15 other tissues See more
Orthologs
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Genomic context

See Rcsd1 in Genome Data Viewer
Location:
1; 1 H2.3
Exon count:
9
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (165476503..165537632, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (165648945..165710063, complement)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene nuclear encoded tRNA proline 2 (anticodon CGG) Neighboring gene translin-associated factor X pseudogene Neighboring gene predicted gene, 51752 Neighboring gene cellular repressor of E1A-stimulated genes 1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC32399

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables actin filament binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables actin filament binding ISO
Inferred from Sequence Orthology
more info
 
enables phosphatidylinositol phosphate binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables retromer complex binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in cellular hyperosmotic response ISO
Inferred from Sequence Orthology
more info
 
involved_in protein localization to endosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in retrograde transport, endosome to Golgi IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in skeletal muscle contraction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
part_of WASH complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in cellular_component ND
No biological Data available
more info
 
is_active_in early endosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
capZ-interacting protein
Names
protein kinase substrate CapZIP

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001038846.1NP_001033935.1  capZ-interacting protein isoform b

    See identical proteins and their annotated locations for NP_001033935.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an in-frame exon in the coding region compared to variant 1. The resulting protein (isoform b) is shorter but has the same N- and C- termini compared to isoform a.
    Source sequence(s)
    AK168816, AK171323, BY230131
    Consensus CDS
    CCDS48425.1
    UniProtKB/Swiss-Prot
    Q3UZA1
    Related
    ENSMUSP00000095082.4, ENSMUST00000097474.9
    Conserved Domains (2) summary
    pfam05177
    Location:201285
    RCSD; RCSD region
    pfam15255
    Location:51136
    CAP-ZIP_m; WASH complex subunit CAP-Z interacting, central region
  2. NM_178593.3NP_848708.2  capZ-interacting protein isoform a

    See identical proteins and their annotated locations for NP_848708.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer protein (isoform a).
    Source sequence(s)
    AK133961, AK168816, BY230131
    Consensus CDS
    CCDS48426.1
    UniProtKB/Swiss-Prot
    Q3UZA1, Q8R3A0
    Related
    ENSMUSP00000043724.9, ENSMUST00000040357.11
    Conserved Domains (3) summary
    COG5271
    Location:200376
    MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]
    pfam05177
    Location:231315
    RCSD; RCSD region
    pfam15255
    Location:90171
    CAP-ZIP_m; WASH complex subunit CAP-Z interacting, central region

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    165476503..165537632 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006496784.2XP_006496847.1  capZ-interacting protein isoform X4

    Conserved Domains (3) summary
    COG5271
    Location:185361
    MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]
    pfam05177
    Location:216300
    RCSD; RCSD region
    pfam15255
    Location:66151
    CAP-ZIP_m; WASH complex subunit CAP-Z interacting, central region
  2. XM_006496781.2XP_006496844.1  capZ-interacting protein isoform X1

    Conserved Domains (3) summary
    COG5271
    Location:215391
    MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]
    pfam05177
    Location:246330
    RCSD; RCSD region
    pfam15255
    Location:96181
    CAP-ZIP_m; WASH complex subunit CAP-Z interacting, central region
  3. XM_006496783.3XP_006496846.1  capZ-interacting protein isoform X3

    See identical proteins and their annotated locations for XP_006496846.1

    UniProtKB/Swiss-Prot
    Q3UZA1, Q8R3A0
    Conserved Domains (3) summary
    COG5271
    Location:200376
    MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]
    pfam05177
    Location:231315
    RCSD; RCSD region
    pfam15255
    Location:90171
    CAP-ZIP_m; WASH complex subunit CAP-Z interacting, central region
  4. XM_011238794.2XP_011237096.1  capZ-interacting protein isoform X2

    See identical proteins and their annotated locations for XP_011237096.1

    Conserved Domains (3) summary
    COG5271
    Location:211387
    MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]
    pfam05177
    Location:242326
    RCSD; RCSD region
    pfam15255
    Location:92177
    CAP-ZIP_m; WASH complex subunit CAP-Z interacting, central region