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Zfp13 zinc finger protein 13 [ Mus musculus (house mouse) ]

Gene ID: 22654, updated on 12-May-2024

Summary

Official Symbol
Zfp13provided by MGI
Official Full Name
zinc finger protein 13provided by MGI
Primary source
MGI:MGI:99159
See related
Ensembl:ENSMUSG00000062012 AllianceGenome:MGI:99159
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Krox-8; Zfp-13
Summary
Enables DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in negative regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Is expressed in several structures, including early conceptus; eye; genitourinary system; hemolymphoid system gland; and liver. Orthologous to human ZNF205 (zinc finger protein 205). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis adult (RPKM 18.2), ovary adult (RPKM 12.7) and 25 other tissues See more
Orthologs
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Genomic context

See Zfp13 in Genome Data Viewer
Location:
17 A3.3; 17 11.72 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (23788820..23818729, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (23569846..23599755, complement)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 6330415G19 gene Neighboring gene caspase 16, apoptosis-related cysteine peptidase Neighboring gene zinc finger protein 213 Neighboring gene STARR-positive B cell enhancer ABC_E9944 Neighboring gene STARR-seq mESC enhancer starr_42052 Neighboring gene STARR-seq mESC enhancer starr_42053 Neighboring gene STARR-seq mESC enhancer starr_42054 Neighboring gene zinc finger and SCAN domain containing 10 Neighboring gene calcium binding protein 39-like pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Gene trapped (2) 
  • Targeted (1) 

General gene information

Markers

Gene Ontology Provided by MGI

Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
transcriptional repressor Rhit
Names
zinc finger protein Krox-8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001356268.2NP_001343197.1  transcriptional repressor Rhit isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC154766
    Consensus CDS
    CCDS89003.1
    UniProtKB/Swiss-Prot
    D7F2B3, P10754, Q80WS0, Q8CDD0
    Related
    ENSMUSP00000111178.4, ENSMUST00000115516.11
    Conserved Domains (4) summary
    COG5048
    Location:326486
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:380400
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:123154
    KRAB; KRAB box
    pfam13465
    Location:280305
    zf-H2C2_2; Zinc-finger double domain
  2. NM_001414203.1NP_001401132.1  transcriptional repressor Rhit isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC154766
  3. NM_001414204.1NP_001401133.1  transcriptional repressor Rhit isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC154766
  4. NM_001414205.1NP_001401134.1  transcriptional repressor Rhit isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC154766
  5. NM_001414207.1NP_001401136.1  transcriptional repressor Rhit isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC154766
  6. NM_001414208.1NP_001401137.1  transcriptional repressor Rhit isoform 7

    Status: VALIDATED

    Source sequence(s)
    AC154766
  7. NM_001414209.1NP_001401138.1  transcriptional repressor Rhit isoform 8

    Status: VALIDATED

    Source sequence(s)
    AC154766
  8. NM_001414210.1NP_001401139.1  transcriptional repressor Rhit isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC154766
  9. NM_001414211.1NP_001401140.1  transcriptional repressor Rhit isoform 9

    Status: VALIDATED

    Source sequence(s)
    AC154766
  10. NM_001414212.1NP_001401141.1  transcriptional repressor Rhit isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC154766
    UniProtKB/Swiss-Prot
    D7F2B3, P10754, Q80WS0, Q8CDD0
  11. NM_011747.4NP_035877.1  transcriptional repressor Rhit isoform 1

    See identical proteins and their annotated locations for NP_035877.1

    Status: VALIDATED

    Source sequence(s)
    AC154766
    Consensus CDS
    CCDS28450.1
    UniProtKB/Swiss-Prot
    P10754
    Related
    ENSMUSP00000054595.5, ENSMUST00000057029.5
    Conserved Domains (4) summary
    COG5048
    Location:319479
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:373393
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:116147
    KRAB; KRAB box
    pfam13465
    Location:273298
    zf-H2C2_2; Zinc-finger double domain

RNA

  1. NR_182255.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC154766

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    23788820..23818729 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011246423.3XP_011244725.1  transcriptional repressor Rhit isoform X2

    See identical proteins and their annotated locations for XP_011244725.1

    Conserved Domains (4) summary
    smart00349
    Location:117172
    KRAB; krueppel associated box
    COG5048
    Location:353513
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:407427
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:307332
    zf-H2C2_2; Zinc-finger double domain
  2. XM_030249750.1XP_030105610.1  transcriptional repressor Rhit isoform X4

    Conserved Domains (4) summary
    COG5048
    Location:336496
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:390410
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:116147
    KRAB; KRAB box
    pfam13465
    Location:290315
    zf-H2C2_2; Zinc-finger double domain
  3. XM_011246421.3XP_011244723.1  transcriptional repressor Rhit isoform X1

    See identical proteins and their annotated locations for XP_011244723.1

    Conserved Domains (4) summary
    smart00349
    Location:124179
    KRAB; krueppel associated box
    COG5048
    Location:360520
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:414434
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:314339
    zf-H2C2_2; Zinc-finger double domain