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Zbtb41 zinc finger and BTB domain containing 41 [ Mus musculus (house mouse) ]

Gene ID: 226470, updated on 8-Dec-2022

Summary

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Official Symbol
Zbtb41provided by MGI
Official Full Name
zinc finger and BTB domain containing 41provided by MGI
Primary source
MGI:MGI:2444487
See related
Ensembl:ENSMUSG00000033964 AllianceGenome:MGI:2444487
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
9430031N01; 8430415N23Rik; 9830132G07Rik
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Is expressed in early conceptus; genitourinary system; and heart. Orthologous to human ZBTB41 (zinc finger and BTB domain containing 41). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E18 (RPKM 5.4), whole brain E14.5 (RPKM 5.0) and 25 other tissues See more
Orthologs
human all
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Genomic context

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See Zbtb41 in Genome Data Viewer
Location:
1; 1 F
Exon count:
13
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (139349738..139380745)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (139422000..139453007)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene crumbs family member 1, photoreceptor morphogenesis associated Neighboring gene RIKEN cDNA 4933436E23 gene Neighboring gene predicted gene, 34816 Neighboring gene abnormal spindle microtubule assembly Neighboring gene coagulation factor XIII, beta subunit

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. ZBTB20 is crucial for the specification of a subset of callosal projection neurons and astrocytes in the mammalian neocortex. Medeiros de Araújo JA, et al. Development, 2021 Aug 15. PMID 34351428, Free PMC Article
  2. The protein interactome of collapsin response mediator protein-2 (CRMP2/DPYSL2) reveals novel partner proteins in brain tissue. Martins-de-Souza D, et al. Proteomics Clin Appl, 2015 Oct. PMID 25921334
  3. Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst. Guo G, et al. Dev Cell, 2010 Apr 20. PMID 20412781
  4. Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method. Piao Y, et al. Genome Res, 2001 Sep. PMID 11544199, Free PMC Article
  5. A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58. Yokoyama S, et al. Dev Cell, 2009 Dec. PMID 20059953, Free PMC Article

See all (18) citations in PubMed

See citations in PubMed for homologs of this gene provided by HomoloGene

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription repressor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in negative regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
zinc finger and BTB domain-containing protein 41
Names
zinc finger and BTB domain containing 41 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001412694.1 → NP_001399623.1  zinc finger and BTB domain-containing protein 41

    Status: VALIDATED

    Source sequence(s)
    AL606536
    UniProtKB/Swiss-Prot
    Q8BYV8

  2. NM_172643.6 → NP_766231.2  zinc finger and BTB domain-containing protein 41

    See identical proteins and their annotated locations for NP_766231.2

    Status: VALIDATED

    Source sequence(s)
    AL606536
    Consensus CDS
    CCDS48385.1
    UniProtKB/Swiss-Prot
    Q811F1, Q8BYV8
    Related
    ENSMUSP00000045570.8, ENSMUST00000039867.10
    Conserved Domains (5) summary
    TIGR01651
    Location:270 → 339
    CobT; cobaltochelatase, CobT subunit
    sd00017
    Location:576 → 596
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:602 → 624
    zf-C2H2; Zinc finger, C2H2 type
    cd18226
    Location:67 → 180
    BTB_POZ_ZBTB41; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 41 (ZBTB41)
    pfam13465
    Location:561 → 585
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    139349738..139380745
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006529446.4 → XP_006529509.1  zinc finger and BTB domain-containing protein 41 isoform X1

    UniProtKB/Swiss-Prot
    Q811F1
    Conserved Domains (5) summary
    TIGR01651
    Location:270 → 339
    CobT; cobaltochelatase, CobT subunit
    sd00017
    Location:576 → 596
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:602 → 624
    zf-C2H2; Zinc finger, C2H2 type
    cd18226
    Location:67 → 180
    BTB_POZ_ZBTB41; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 41 (ZBTB41)
    pfam13465
    Location:561 → 585
    zf-H2C2_2; Zinc-finger double domain

  2. XM_006529448.4 → XP_006529511.1  zinc finger and BTB domain-containing protein 41 isoform X1

    See identical proteins and their annotated locations for XP_006529511.1

    UniProtKB/Swiss-Prot
    Q811F1, Q8BYV8
    Conserved Domains (5) summary
    TIGR01651
    Location:270 → 339
    CobT; cobaltochelatase, CobT subunit
    sd00017
    Location:576 → 596
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:602 → 624
    zf-C2H2; Zinc finger, C2H2 type
    cd18226
    Location:67 → 180
    BTB_POZ_ZBTB41; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 41 (ZBTB41)
    pfam13465
    Location:561 → 585
    zf-H2C2_2; Zinc-finger double domain

  3. XM_036163983.1 → XP_036019876.1  zinc finger and BTB domain-containing protein 41 isoform X2

    Conserved Domains (3) summary
    sd00017
    Location:362 → 382
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cd18226
    Location:67 → 180
    BTB_POZ_ZBTB41; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 41 (ZBTB41)
    pfam13465
    Location:476 → 501
    zf-H2C2_2; Zinc-finger double domain

  4. XM_006529447.5 → XP_006529510.1  zinc finger and BTB domain-containing protein 41 isoform X1

    See identical proteins and their annotated locations for XP_006529510.1

    UniProtKB/Swiss-Prot
    Q811F1, Q8BYV8
    Conserved Domains (5) summary
    TIGR01651
    Location:270 → 339
    CobT; cobaltochelatase, CobT subunit
    sd00017
    Location:576 → 596
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:602 → 624
    zf-C2H2; Zinc finger, C2H2 type
    cd18226
    Location:67 → 180
    BTB_POZ_ZBTB41; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 41 (ZBTB41)
    pfam13465
    Location:561 → 585
    zf-H2C2_2; Zinc-finger double domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q811F1.4 GenPept UniProtKB/Swiss-Prot:Q811F1

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