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Rnf103 ring finger protein 103 [ Mus musculus (house mouse) ]

Gene ID: 22644, updated on 4-Nov-2022

Summary

Official Symbol
Rnf103provided by MGI
Official Full Name
ring finger protein 103provided by MGI
Primary source
MGI:MGI:109483
See related
Ensembl:ENSMUSG00000052656 AllianceGenome:MGI:109483
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
kf-1; Zfp103
Summary
This gene encodes a member of the RING finger family of E3 ubiquitin-protein ligases. These proteins catalyze the transfer of the ubiquitin protein from a ubiquitin E2 enzyme to a protein substrate. Homozygous knockout mice for this gene exhibit enhanced anxiety-like behavior. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2015]
Expression
Ubiquitous expression in colon adult (RPKM 26.1), duodenum adult (RPKM 20.1) and 28 other tissues See more
Orthologs
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Genomic context

See Rnf103 in Genome Data Viewer
Location:
6 C1; 6 32.16 cM
Exon count:
5
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (71470828..71487864)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (71493844..71510880)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene required for meiotic nuclear division 5 homolog A Neighboring gene predicted gene, 30582 Neighboring gene charged multivesicular body protein 3 Neighboring gene lysine (K)-specific demethylase 3A

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1)  1 citation
  • Endonuclease-mediated (1) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
enables ubiquitin-protein transferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables ubiquitin-protein transferase activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in protein ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in protein ubiquitination ISO
Inferred from Sequence Orthology
more info
 
involved_in ubiquitin-dependent ERAD pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in ubiquitin-dependent ERAD pathway ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
E3 ubiquitin-protein ligase RNF103
Names
RING-type E3 ubiquitin transferase RNF103
zinc finger protein 103
NP_001295232.1
NP_033569.2
XP_036021921.1
XP_036021922.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001308303.2NP_001295232.1  E3 ubiquitin-protein ligase RNF103 isoform 2

    See identical proteins and their annotated locations for NP_001295232.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site in its 3' terminal exon, resulting in a distinct 5' UTR and the use of a downstream in-frame start site, compared to variant 1. The encoded isoform (2) has a shorter N-terminus compared to isoform 1. Variants 2-4 all encode the same isoform (2).
    Source sequence(s)
    AC154001
    UniProtKB/TrEMBL
    Q3TGP6, Q3UYK9
    Conserved Domains (1) summary
    cd16473
    Location:444489
    RING-H2_RNF103; RING finger, H2 subclass, found in RING finger protein 103 (RNF103) and similar proteins
  2. NM_001410507.1NP_001397436.1  E3 ubiquitin-protein ligase RNF103 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC154001
    UniProtKB/TrEMBL
    Q3TGP6
  3. NM_001410508.1NP_001397437.1  E3 ubiquitin-protein ligase RNF103 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC154001
    UniProtKB/TrEMBL
    Q3TGP6
  4. NM_009543.4NP_033569.2  E3 ubiquitin-protein ligase RNF103 isoform 1

    See identical proteins and their annotated locations for NP_033569.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AC154001
    Consensus CDS
    CCDS39508.1
    UniProtKB/Swiss-Prot
    O08883, Q9R1W3
    UniProtKB/TrEMBL
    Q3UYK9
    Related
    ENSMUSP00000066324.5, ENSMUST00000064637.11
    Conserved Domains (1) summary
    cd00162
    Location:618661
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    71470828..71487864
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036166029.1XP_036021922.1  E3 ubiquitin-protein ligase RNF103 isoform X2

    UniProtKB/TrEMBL
    D3Z0Y5
    Related
    ENSMUSP00000109816.2, ENSMUST00000114178.8
  2. XM_036166028.1XP_036021921.1  E3 ubiquitin-protein ligase RNF103 isoform X1