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Yod1 YOD1 deubiquitinase [ Mus musculus (house mouse) ]

Gene ID: 226418, updated on 18-Apr-2024

Summary

Official Symbol
Yod1provided by MGI
Official Full Name
YOD1 deubiquitinaseprovided by MGI
Primary source
MGI:MGI:2442596
See related
Ensembl:ENSMUSG00000046404 AllianceGenome:MGI:2442596
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Hshin7; 6330564D18Rik; 9930028C20Rik
Summary
Predicted to enable Lys48-specific deubiquitinase activity; thiol-dependent deubiquitinase; and ubiquitin protein ligase binding activity. Predicted to be involved in several processes, including negative regulation of retrograde protein transport, ER to cytosol; protein deubiquitination; and ubiquitin-dependent ERAD pathway. Predicted to act upstream of or within response to unfolded protein. Predicted to be located in cytoplasm. Is expressed in several structures, including adrenal gland; alimentary system; brain; genitourinary system; and respiratory system. Orthologous to human YOD1 (YOD1 deubiquitinase). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis adult (RPKM 8.7), liver E14 (RPKM 3.4) and 28 other tissues See more
Orthologs
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Genomic context

Location:
1 E4; 1 56.89 cM
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (130645064..130652093)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (130717327..130722073)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene complement component 4 binding protein Neighboring gene STARR-seq mESC enhancer starr_02200 Neighboring gene complement component 4 binding protein, pseudogene 1 Neighboring gene 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2 Neighboring gene STARR-positive B cell enhancer ABC_E1230 Neighboring gene STARR-seq mESC enhancer starr_02204 Neighboring gene expressed sequence AA986860 Neighboring gene predicted gene 28857 Neighboring gene predicted gene 28856 Neighboring gene STARR-seq mESC enhancer starr_02205

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (2) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables K48-linked deubiquitinase activity ISO
Inferred from Sequence Orthology
more info
 
enables cysteine-type deubiquitinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables cysteine-type deubiquitinase activity ISO
Inferred from Sequence Orthology
more info
 
enables cysteine-type peptidase activity IEA
Inferred from Electronic Annotation
more info
 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables peptidase activity IEA
Inferred from Electronic Annotation
more info
 
enables ubiquitin protein ligase binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in ERAD pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in ERAD pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in endoplasmic reticulum unfolded protein response IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in endoplasmic reticulum unfolded protein response ISO
Inferred from Sequence Orthology
more info
 
involved_in macroautophagy ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of retrograde protein transport, ER to cytosol ISO
Inferred from Sequence Orthology
more info
 
involved_in protein K11-linked deubiquitination ISO
Inferred from Sequence Orthology
more info
 
involved_in protein K27-linked deubiquitination ISO
Inferred from Sequence Orthology
more info
 
involved_in protein K29-linked deubiquitination ISO
Inferred from Sequence Orthology
more info
 
involved_in protein K33-linked deubiquitination ISO
Inferred from Sequence Orthology
more info
 
involved_in protein K48-linked deubiquitination ISO
Inferred from Sequence Orthology
more info
 
involved_in protein K63-linked deubiquitination ISO
Inferred from Sequence Orthology
more info
 
involved_in protein deubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within proteolysis IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within response to unfolded protein IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
ubiquitin thioesterase OTU1
Names
HIV-induced protein-7-like protease
YOD1 OTU deubiquitinating enzyme 1 homologue
NP_848806.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_178691.5NP_848806.2  ubiquitin thioesterase OTU1

    See identical proteins and their annotated locations for NP_848806.2

    Status: VALIDATED

    Source sequence(s)
    AC139231
    Consensus CDS
    CCDS48351.1
    UniProtKB/Swiss-Prot
    B2RSW9, Q8BPM9, Q8CB24, Q8CB27
    UniProtKB/TrEMBL
    A4FTZ0
    Related
    ENSMUSP00000055318.5, ENSMUST00000049813.6
    Conserved Domains (3) summary
    COG5539
    Location:72342
    COG5539; Predicted cysteine protease (OTU family) [Posttranslational modification, protein turnover, chaperones]
    cl00155
    Location:4184
    UBQ; Ubiquitin-like proteins
    cl19932
    Location:150265
    OTU; OTU-like cysteine protease

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    130645064..130652093
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)