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Lct lactase [ Mus musculus (house mouse) ]

Gene ID: 226413, updated on 12-Aug-2019

Summary

Official Symbol
Lctprovided by MGI
Official Full Name
lactaseprovided by MGI
Primary source
MGI:MGI:104576
See related
Ensembl:ENSMUSG00000026354
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
LAC; LPH; Lphl; Gm100
Expression
Biased expression in duodenum adult (RPKM 123.5), small intestine adult (RPKM 101.4) and 1 other tissue See more
Orthologs

Genomic context

See Lct in Genome Data Viewer
Location:
1 E3; 1 55.8 cM
Exon count:
17
Annotation release Status Assembly Chr Location
108 current GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (128284756..128328318, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 1 NC_000067.5 (130181341..130224895, complement)

Chromosome 1 - NC_000067.6Genomic Context describing neighboring genes Neighboring gene R3H domain containing 1 Neighboring gene microRNA 128-1 Neighboring gene predicted gene, 41949 Neighboring gene UBX domain protein 4 Neighboring gene minichromosome maintenance complex component 6 Neighboring gene aspartyl-tRNA synthetase

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 

Pathways from BioSystems

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
beta-glucosidase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
lactase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
lactase activity ISO
Inferred from Sequence Orthology
more info
 
transferase activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
response to drug ISO
Inferred from Sequence Orthology
more info
 
response to ethanol ISO
Inferred from Sequence Orthology
more info
 
response to hypoxia ISO
Inferred from Sequence Orthology
more info
 
response to iron(II) ion ISO
Inferred from Sequence Orthology
more info
 
response to lead ion ISO
Inferred from Sequence Orthology
more info
 
response to nickel cation ISO
Inferred from Sequence Orthology
more info
 
response to nutrient ISO
Inferred from Sequence Orthology
more info
 
response to organic substance ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
brush border ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
lactase-phlorizin hydrolase
NP_001074547.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001081078.2NP_001074547.1  lactase-phlorizin hydrolase preproprotein

    See identical proteins and their annotated locations for NP_001074547.1

    Status: VALIDATED

    Source sequence(s)
    AC161809
    Consensus CDS
    CCDS35698.1
    UniProtKB/TrEMBL
    F8VPT3
    Related
    ENSMUSP00000073190.6, ENSMUST00000073490.6
    Conserved Domains (2) summary
    pfam00232
    Location:13771844
    Glyco_hydro_1; Glycosyl hydrolase family 1
    cl23725
    Location:380849
    Glyco_hydro_1; Glycosyl hydrolase family 1

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p6 C57BL/6J

Genomic

  1. NC_000067.6 Reference GRCm38.p6 C57BL/6J

    Range
    128284756..128328318 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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