C1ql2 complement component 1, q subcomponent-like 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: C1ql2provided by MGI
Official Full Name: complement component 1, q subcomponent-like 2provided by MGI
Primary source: MGI:MGI:3032521
See related: Ensembl:ENSMUSG00000036907 AllianceGenome:MGI:3032521
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Adii; CTRP10
Summary: Enables identical protein binding activity. Located in extracellular region. Part of protein-containing complex. Is expressed in brain. Orthologous to human C1QL2 (complement C1q like 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in cortex adult (RPKM 1.9), CNS E18 (RPKM 1.8) and 8 other tissues See more
Orthologs: human all
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Genomic context

Location:: 1; 1 E2.3

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
109	current	GRCm39 (GCF_000001635.27)	1	NC_000067.7 (120268312..120270903)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	1	NC_000067.6 (120340582..120343174)

Chromosome 1 - NC_000067.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

characterization of nCLP2: cDNA sequencing, amino acid sequence, sequence alignment/homology with isoproteins, tissue localization (primarily retina & hippocampus [mossy fibers]), trimer structure/disulfide bridges, signal sequence suggests secretion
Title: Identification and characterization of nCLP2, a novel C1q family protein expressed in the central nervous system.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1) 1 citation
Endonuclease-mediated (4) 1 citation

General gene information

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Markers

C1ql2 (e-PCR), detects polymorphism
- UniSTS:531287

C1ql2 (e-PCR), detects polymorphism
- UniSTS:531052

Homology

Homologs of the C1ql2 gene: The C1ql2 gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, rat, and zebrafish.
Orthologs from Annotation Pipeline: 412 organisms have orthologs with human gene C1ql2
Orthologs

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables identical protein binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in neurotransmitter receptor localization to postsynaptic specialization membrane	IDA Inferred from Direct Assay more info	PubMed
involved_in neurotransmitter receptor localization to postsynaptic specialization membrane	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in postsynaptic density assembly	IDA Inferred from Direct Assay more info	PubMed
involved_in postsynaptic density assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of synapse maturation	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of synapse maturation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cerebellar climbing fiber to Purkinje cell synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in cerebellar climbing fiber to Purkinje cell synapse	IMP Inferred from Mutant Phenotype more info	PubMed
part_of collagen trimer	IEA Inferred from Electronic Annotation more info
located_in extracellular region	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IMP Inferred from Mutant Phenotype more info	PubMed
is_active_in hippocampal mossy fiber to CA3 synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in hippocampal mossy fiber to CA3 synapse	IMP Inferred from Mutant Phenotype more info	PubMed
part_of protein-containing complex	IDA Inferred from Direct Assay more info	PubMed
is_active_in synaptic cleft	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: complement C1q-like protein 2

Names: C1q and tumor necrosis factor-related protein 10; C1q/TNF-related protein 10; C1qTNF10; adiponectin i

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.