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Zan zonadhesin [ Mus musculus (house mouse) ]

Gene ID: 22635, updated on 26-Sep-2022

Summary

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Official Symbol
Zanprovided by MGI
Official Full Name
zonadhesinprovided by MGI
Primary source
MGI:MGI:106656
See related
Ensembl:ENSMUSG00000079173 AllianceGenome:MGI:106656
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Zan-test
Summary
Predicted to enable extracellular matrix binding activity. Acts upstream of or within regulation of binding activity of sperm to zona pellucida. Predicted to be located in plasma membrane. Predicted to be active in extracellular matrix and extracellular space. Orthologous to human ZAN (zonadhesin). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in colon adult (RPKM 10.7), testis adult (RPKM 4.9) and 3 other tissues See more
Orthologs
human all
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Genomic context

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See Zan in Genome Data Viewer
Location:
5 G2; 5 76.4 cM
Exon count:
91
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (137376899..137475326, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (137378637..137477064, complement)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 52791 Neighboring gene Eph receptor B4 Neighboring gene ribosomal protein L36, pseudogene 9 Neighboring gene predicted gene, 38725 Neighboring gene predicted gene, 36056 Neighboring gene erythropoietin

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Regulatory T cells control tolerogenic versus autoimmune response to sperm in vasectomy. Wheeler K, et al. Proc Natl Acad Sci U S A, 2011 May 3. PMID 21502500, Free PMC Article
  2. Species diversity in the structure of zonadhesin, a sperm-specific membrane protein containing multiple cell adhesion molecule-like domains. Gao Z, et al. J Biol Chem, 1998 Feb 6. PMID 9452463
  3. Zonadhesin is essential for species specificity of sperm adhesion to the egg zona pellucida. Tardif S, et al. J Biol Chem, 2010 Aug 6. PMID 20529856, Free PMC Article
  4. A sperm membrane protein that binds in a species-specific manner to the egg extracellular matrix is homologous to von Willebrand factor. Hardy DM, et al. J Biol Chem, 1995 Nov 3. PMID 7592795
  5. Genetic analysis of inferior nurturing ability in RR mice. Suto J, et al. Reproduction, 2002 Jan. PMID 11869186

See all (21) citations in PubMed

See citations in PubMed for homologs of this gene provided by HomoloGene

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Zonadhesin is essential for species specificity of sperm adhesion to the egg zona pellucida
    Title: Zonadhesin is essential for species specificity of sperm adhesion to the egg zona pellucida.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1)  1 citation
  • Endonuclease-mediated (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables extracellular matrix binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within binding of sperm to zona pellucida ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within cell adhesion IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within regulation of binding of sperm to zona pellucida IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in extracellular matrix IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
zonadhesin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_011741.2 → NP_035871.2  zonadhesin precursor

    Status: VALIDATED

    Source sequence(s)
    AC148018, AC150682
    Consensus CDS
    CCDS51672.1
    UniProtKB/TrEMBL
    E9PWQ7
    Related
    ENSMUSP00000114068.2, ENSMUST00000117564.8
    Conserved Domains (9) summary
    cd06263
    Location:379 → 540
    MAM; Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members ...
    smart00832
    Location:1911 → 1982
    C8; This domain contains 8 conserved cysteine residues
    pfam00094
    Location:1715 → 1865
    VWD; von Willebrand factor type D domain
    pfam00629
    Location:379 → 542
    MAM; MAM domain, meprin/A5/mu
    pfam01826
    Location:1599 → 1652
    TIL; Trypsin Inhibitor like cysteine rich domain
    pfam08742
    Location:2310 → 2380
    C8; C8 domain
    pfam12714
    Location:3521 → 3575
    TILa; TILa domain
    pfam15950
    Location:729 → 899
    DUF4758; Domain of unknown function (DUF4758)
    cl17735
    Location:5249 → 5302
    VWC; von Willebrand factor type C domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    137376899..137475326 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036165001.1 → XP_036020894.1  zonadhesin isoform X2

    Conserved Domains (9) summary
    smart00832
    Location:1895 → 1966
    C8; This domain contains 8 conserved cysteine residues
    pfam05109
    Location:546 → 940
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    pfam12714
    Location:3505 → 3559
    TILa; TILa domain
    cl17735
    Location:2025 → 2080
    VWC; von Willebrand factor type C domain
    pfam00094
    Location:1699 → 1849
    VWD; von Willebrand factor type D domain
    pfam00629
    Location:379 → 541
    MAM; MAM domain, meprin/A5/mu
    pfam01826
    Location:5178 → 5231
    TIL; Trypsin Inhibitor like cysteine rich domain
    pfam08742
    Location:2306 → 2364
    C8; C8 domain
    cd19941
    Location:1583 → 1636
    TIL; trypsin inhibitor-like cysteine rich domain

  2. XM_036165003.1 → XP_036020896.1  zonadhesin isoform X4

    Conserved Domains (9) summary
    smart00832
    Location:1871 → 1942
    C8; This domain contains 8 conserved cysteine residues
    pfam05109
    Location:546 → 940
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    pfam12714
    Location:3481 → 3535
    TILa; TILa domain
    cl17735
    Location:2001 → 2056
    VWC; von Willebrand factor type C domain
    pfam00094
    Location:1675 → 1825
    VWD; von Willebrand factor type D domain
    pfam00629
    Location:379 → 541
    MAM; MAM domain, meprin/A5/mu
    pfam01826
    Location:5154 → 5207
    TIL; Trypsin Inhibitor like cysteine rich domain
    pfam08742
    Location:2282 → 2340
    C8; C8 domain
    cd19941
    Location:1559 → 1612
    TIL; trypsin inhibitor-like cysteine rich domain

  3. XM_036165000.1 → XP_036020893.1  zonadhesin isoform X1

    Conserved Domains (9) summary
    smart00832
    Location:1906 → 1977
    C8; This domain contains 8 conserved cysteine residues
    pfam05109
    Location:546 → 940
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    pfam12714
    Location:3516 → 3570
    TILa; TILa domain
    cl17735
    Location:2036 → 2091
    VWC; von Willebrand factor type C domain
    pfam00094
    Location:1710 → 1860
    VWD; von Willebrand factor type D domain
    pfam00629
    Location:379 → 541
    MAM; MAM domain, meprin/A5/mu
    pfam01826
    Location:5189 → 5242
    TIL; Trypsin Inhibitor like cysteine rich domain
    pfam08742
    Location:2317 → 2375
    C8; C8 domain
    cd19941
    Location:1594 → 1647
    TIL; trypsin inhibitor-like cysteine rich domain

  4. XM_036165005.1 → XP_036020898.1  zonadhesin isoform X6

    Conserved Domains (9) summary
    smart00832
    Location:1911 → 1982
    C8; This domain contains 8 conserved cysteine residues
    pfam05109
    Location:546 → 940
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    pfam12714
    Location:3281 → 3335
    TILa; TILa domain
    cl17735
    Location:2041 → 2096
    VWC; von Willebrand factor type C domain
    pfam00094
    Location:1715 → 1865
    VWD; von Willebrand factor type D domain
    pfam00629
    Location:379 → 541
    MAM; MAM domain, meprin/A5/mu
    pfam01826
    Location:4954 → 5007
    TIL; Trypsin Inhibitor like cysteine rich domain
    pfam08742
    Location:2322 → 2380
    C8; C8 domain
    cd19941
    Location:1599 → 1652
    TIL; trypsin inhibitor-like cysteine rich domain

  5. XM_036165004.1 → XP_036020897.1  zonadhesin isoform X5

    Conserved Domains (9) summary
    smart00832
    Location:1911 → 1982
    C8; This domain contains 8 conserved cysteine residues
    pfam05109
    Location:546 → 940
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    pfam12714
    Location:3401 → 3455
    TILa; TILa domain
    cl17735
    Location:2041 → 2096
    VWC; von Willebrand factor type C domain
    pfam00094
    Location:1715 → 1865
    VWD; von Willebrand factor type D domain
    pfam00629
    Location:379 → 541
    MAM; MAM domain, meprin/A5/mu
    pfam01826
    Location:5074 → 5127
    TIL; Trypsin Inhibitor like cysteine rich domain
    pfam08742
    Location:2322 → 2380
    C8; C8 domain
    cd19941
    Location:1599 → 1652
    TIL; trypsin inhibitor-like cysteine rich domain

  6. XM_036165002.1 → XP_036020895.1  zonadhesin isoform X3

    Conserved Domains (10) summary
    cd06263
    Location:217 → 345
    MAM; Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members ...
    smart00832
    Location:1885 → 1956
    C8; This domain contains 8 conserved cysteine residues
    pfam05109
    Location:520 → 914
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    pfam12714
    Location:3495 → 3549
    TILa; TILa domain
    cl17735
    Location:2015 → 2070
    VWC; von Willebrand factor type C domain
    pfam00094
    Location:1689 → 1839
    VWD; von Willebrand factor type D domain
    pfam00629
    Location:353 → 515
    MAM; MAM domain, meprin/A5/mu
    pfam01826
    Location:5168 → 5221
    TIL; Trypsin Inhibitor like cysteine rich domain
    pfam08742
    Location:2296 → 2354
    C8; C8 domain
    cd19941
    Location:1573 → 1626
    TIL; trypsin inhibitor-like cysteine rich domain

  7. XM_017320810.1 → XP_017176299.1  zonadhesin isoform X7

    Conserved Domains (9) summary
    PHA03255
    Location:777 → 932
    PHA03255; BDLF3; Provisional
    smart00832
    Location:1911 → 1982
    C8; This domain contains 8 conserved cysteine residues
    pfam12714
    Location:3521 → 3575
    TILa; TILa domain
    cl17735
    Location:2041 → 2096
    VWC; von Willebrand factor type C domain
    pfam00094
    Location:1715 → 1865
    VWD; von Willebrand factor type D domain
    pfam00629
    Location:379 → 541
    MAM; MAM domain, meprin/A5/mu
    pfam01826
    Location:1599 → 1652
    TIL; Trypsin Inhibitor like cysteine rich domain
    pfam08742
    Location:2322 → 2380
    C8; C8 domain
    pfam17823
    Location:546 → 838
    DUF5585; Family of unknown function (DUF5585)

  8. XM_017320811.1 → XP_017176300.1  zonadhesin isoform X8

    Conserved Domains (9) summary
    PHA03255
    Location:777 → 932
    PHA03255; BDLF3; Provisional
    smart00832
    Location:1911 → 1982
    C8; This domain contains 8 conserved cysteine residues
    pfam12714
    Location:3521 → 3575
    TILa; TILa domain
    cl17735
    Location:2041 → 2096
    VWC; von Willebrand factor type C domain
    pfam00094
    Location:1715 → 1865
    VWD; von Willebrand factor type D domain
    pfam00629
    Location:379 → 541
    MAM; MAM domain, meprin/A5/mu
    pfam01826
    Location:1599 → 1652
    TIL; Trypsin Inhibitor like cysteine rich domain
    pfam08742
    Location:2322 → 2380
    C8; C8 domain
    pfam17823
    Location:546 → 838
    DUF5585; Family of unknown function (DUF5585)

  9. XM_036165006.1 → XP_036020899.1  zonadhesin isoform X9

    Conserved Domains (9) summary
    smart00832
    Location:1911 → 1982
    C8; This domain contains 8 conserved cysteine residues
    pfam05109
    Location:546 → 940
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    pfam12714
    Location:3521 → 3575
    TILa; TILa domain
    cl17735
    Location:2041 → 2096
    VWC; von Willebrand factor type C domain
    pfam00094
    Location:1715 → 1865
    VWD; von Willebrand factor type D domain
    pfam00629
    Location:379 → 541
    MAM; MAM domain, meprin/A5/mu
    pfam01826
    Location:1985 → 2039
    TIL; Trypsin Inhibitor like cysteine rich domain
    pfam08742
    Location:2322 → 2380
    C8; C8 domain
    cd19941
    Location:1599 → 1652
    TIL; trypsin inhibitor-like cysteine rich domain

  10. XM_017320813.2 → XP_017176302.1  zonadhesin isoform X10

    Conserved Domains (9) summary
    smart00832
    Location:1911 → 1982
    C8; This domain contains 8 conserved cysteine residues
    TIGR03835
    Location:817 → 1153
    termin_org_DnaJ; terminal organelle assembly protein TopJ
    pfam05109
    Location:546 → 940
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    pfam12714
    Location:3521 → 3575
    TILa; TILa domain
    cl17735
    Location:2041 → 2096
    VWC; von Willebrand factor type C domain
    pfam00094
    Location:1715 → 1865
    VWD; von Willebrand factor type D domain
    pfam00629
    Location:379 → 541
    MAM; MAM domain, meprin/A5/mu
    pfam01826
    Location:1599 → 1652
    TIL; Trypsin Inhibitor like cysteine rich domain
    pfam08742
    Location:2322 → 2380
    C8; C8 domain

  11. XM_017320814.1 → XP_017176303.1  zonadhesin isoform X11

    Conserved Domains (9) summary
    smart00832
    Location:1911 → 1982
    C8; This domain contains 8 conserved cysteine residues
    TIGR03835
    Location:817 → 1153
    termin_org_DnaJ; terminal organelle assembly protein TopJ
    pfam05109
    Location:546 → 940
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    pfam12714
    Location:3521 → 3575
    TILa; TILa domain
    cl17735
    Location:2041 → 2096
    VWC; von Willebrand factor type C domain
    pfam00094
    Location:1715 → 1865
    VWD; von Willebrand factor type D domain
    pfam00629
    Location:379 → 541
    MAM; MAM domain, meprin/A5/mu
    pfam01826
    Location:1599 → 1652
    TIL; Trypsin Inhibitor like cysteine rich domain
    pfam08742
    Location:2322 → 2380
    C8; C8 domain

RNA

  1. XR_003955622.1 RNA Sequence

  2. XR_003955623.1 RNA Sequence

  3. XR_001784667.1 RNA Sequence

  4. XR_001784665.1 RNA Sequence

  5. XR_001784666.1 RNA Sequence

  6. XR_004942494.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O88799.1 GenPept UniProtKB/Swiss-Prot:O88799

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