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Glis3 GLIS family zinc finger 3 [ Mus musculus (house mouse) ]

Gene ID: 226075, updated on 6-Jun-2024

Summary

Official Symbol
Glis3provided by MGI
Official Full Name
GLIS family zinc finger 3provided by MGI
Primary source
MGI:MGI:2444289
See related
Ensembl:ENSMUSG00000052942 AllianceGenome:MGI:2444289
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
4833409N03Rik; E330013K21Rik
Summary
This gene is a member of the GLI-similar zinc finger protein family and encodes a nuclear protein which contains multiple C2H2-type zinc finger domains. This protein functions as both a repressor and activator of transcription and is specifically involved in the transcriptional regulation of insulin. It is thought to enhance GLI-RE-dependent transcription by binding to the GLI-RE consensus sequence (GACCACCCAC). Mutations in a similar gene in human have been associated with neonatal diabetes and congenital hypothyroidism (NDH). Alternatively spliced transcript variants have been identified. [provided by RefSeq, Mar 2015]
Expression
Broad expression in kidney adult (RPKM 6.0), ovary adult (RPKM 1.9) and 18 other tissues See more
Orthologs
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Genomic context

See Glis3 in Genome Data Viewer
Location:
19 C1; 19 22.88 cM
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (28236251..28657684, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (28258851..28680265, complement)

Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene peptidylprolyl isomerase A pseudogene chr19_428.1 Neighboring gene STARR-seq mESC enhancer starr_45853 Neighboring gene STARR-seq mESC enhancer starr_45855 Neighboring gene STARR-seq mESC enhancer starr_45856 Neighboring gene UPF0729 protein C18orf32 homolog pseudogene Neighboring gene predicted gene, 35866 Neighboring gene STARR-seq mESC enhancer starr_45859 Neighboring gene STARR-seq mESC enhancer starr_45862 Neighboring gene STARR-seq mESC enhancer starr_45863 Neighboring gene RIKEN cDNA D930032P07 gene Neighboring gene ribosomal protein S15A, pseudogene 2 Neighboring gene predicted gene, 35922 Neighboring gene dynein family member

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (6)  1 citation

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • E230012L24

Gene Ontology Provided by MGI

Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
zinc finger protein GLIS3
Names
GLI-similar 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001305671.1NP_001292600.1  zinc finger protein GLIS3 isoform 2

    See identical proteins and their annotated locations for NP_001292600.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an internal exon compared to variant 1. This variant represents translation initiation at a downstream AUG compared to variant 1; the 5'-most initiation codon, as used in variant 1, is associated with a truncated ORF that would render the transcript a candidate for nonsense-mediated decay (NMD). Leaky scanning may allow translation initiation at the downstream AUG to encode an isoform (2) that has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AC118934, AK087731, BP768786, CK640192, DQ871027
    UniProtKB/TrEMBL
    A2VDF9
    Conserved Domains (3) summary
    sd00017
    Location:293315
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:307334
    zf-H2C2_2; Zinc-finger double domain
    pfam15909
    Location:293380
    zf-C2H2_8; C2H2-type zinc ribbon
  2. NM_001404124.1NP_001391053.1  zinc finger protein GLIS3 isoform 1

    Status: REVIEWED

    Source sequence(s)
    AC116137, AC116863, AC118934, AC161521
    UniProtKB/TrEMBL
    A2VDF9, Q0GE24
  3. NM_175459.6NP_780668.3  zinc finger protein GLIS3 isoform 1

    See identical proteins and their annotated locations for NP_780668.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC118934, AK087731, BP768786, CK640192, DQ871027
    Consensus CDS
    CCDS37947.1
    UniProtKB/TrEMBL
    A2VDF9, Q0GE24
    Related
    ENSMUSP00000124635.2, ENSMUST00000162022.8
    Conserved Domains (3) summary
    PHA03247
    Location:612861
    PHA03247; large tegument protein UL36; Provisional
    COG5189
    Location:558652
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    sd00017
    Location:569591
    ZF_C2H2; C2H2 Zn finger [structural motif]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000085.7 Reference GRCm39 C57BL/6J

    Range
    28236251..28657684 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006526985.5XP_006527048.1  zinc finger protein GLIS3 isoform X2

    See identical proteins and their annotated locations for XP_006527048.1

    UniProtKB/Swiss-Prot
    Q6XP49, Q8BI60
    UniProtKB/TrEMBL
    A2VDF9
    Conserved Domains (3) summary
    PHA03247
    Location:457706
    PHA03247; large tegument protein UL36; Provisional
    COG5189
    Location:403497
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    sd00017
    Location:414436
    ZF_C2H2; C2H2 Zn finger [structural motif]
  2. XM_036161561.1XP_036017454.1  zinc finger protein GLIS3 isoform X3

    Conserved Domains (2) summary
    COG5048
    Location:565672
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:569591
    ZF_C2H2; C2H2 Zn finger [structural motif]
  3. XM_036161562.1XP_036017455.1  zinc finger protein GLIS3 isoform X4

    Related
    ENSMUSP00000108231.3, ENSMUST00000112612.9
    Conserved Domains (2) summary
    COG5189
    Location:558652
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    sd00017
    Location:569591
    ZF_C2H2; C2H2 Zn finger [structural motif]
  4. XM_006526987.5XP_006527050.1  zinc finger protein GLIS3 isoform X5

    Conserved Domains (2) summary
    COG5048
    Location:565621
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:569591
    ZF_C2H2; C2H2 Zn finger [structural motif]