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Lrfn4 leucine rich repeat and fibronectin type III domain containing 4 [ Mus musculus (house mouse) ]

Gene ID: 225875, updated on 8-Dec-2022

Summary

Official Symbol
Lrfn4provided by MGI
Official Full Name
leucine rich repeat and fibronectin type III domain containing 4provided by MGI
Primary source
MGI:MGI:2385612
See related
Ensembl:ENSMUSG00000045045 AllianceGenome:MGI:2385612
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Salm3
Summary
Involved in regulation of presynapse assembly and synaptic membrane adhesion. Located in GABA-ergic synapse; cell surface; and glutamatergic synapse. Is expressed in several structures, including central nervous system; liver; primary head vein; reproductive system; and sensory organ. Orthologous to human LRFN4 (leucine rich repeat and fibronectin type III domain containing 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in ovary adult (RPKM 41.2), colon adult (RPKM 28.0) and 22 other tissues See more
Orthologs
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Genomic context

See Lrfn4 in Genome Data Viewer
Location:
19; 19 A
Exon count:
3
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (4661812..4665962, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (4611784..4615667, complement)

Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA A930001C03 gene Neighboring gene synaptotagmin XII Neighboring gene RIKEN cDNA 2010003K11 gene Neighboring gene pyruvate carboxylase Neighboring gene microRNA 6986 Neighboring gene predicted gene 960 Neighboring gene Ras converting CAAX endopeptidase 1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC36464, MGC36545

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
is_active_in GABA-ergic synapse IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in GABA-ergic synapse IMP
Inferred from Mutant Phenotype
more info
PubMed 
is_active_in cell surface IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cell surface IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in glutamatergic synapse IMP
Inferred from Mutant Phenotype
more info
PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in postsynaptic density membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in postsynaptic density membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
leucine-rich repeat and fibronectin type-III domain-containing protein 4
Names
synaptic adhesion-like molecule 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_153388.4NP_700437.2  leucine-rich repeat and fibronectin type-III domain-containing protein 4 precursor

    See identical proteins and their annotated locations for NP_700437.2

    Status: VALIDATED

    Source sequence(s)
    AI415633, AK163603, CA752061
    Consensus CDS
    CCDS29431.1
    UniProtKB/Swiss-Prot
    Q80XU8, Q8K3C4
    UniProtKB/TrEMBL
    A0A6P5NZX6, A0A8C6GHU4
    Related
    ENSMUSP00000109453.3, ENSMUST00000113822.3
    Conserved Domains (5) summary
    smart00082
    Location:234278
    LRRCT; Leucine rich repeat C-terminal domain
    COG4886
    Location:39205
    LRR; Leucine-rich repeat (LRR) protein [Transcription]
    sd00033
    Location:5073
    LRR_RI; leucine-rich repeat [structural motif]
    pfam00041
    Location:409478
    fn3; Fibronectin type III domain
    cl11960
    Location:295368
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000085.7 Reference GRCm39 C57BL/6J

    Range
    4661812..4665962 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017318142.3XP_017173631.1  leucine-rich repeat and fibronectin type-III domain-containing protein 4 isoform X1

    UniProtKB/Swiss-Prot
    Q80XU8, Q8K3C4
    UniProtKB/TrEMBL
    A0A6P5NZX6, A0A8C6GHU4
    Related
    ENSMUSP00000050039.3, ENSMUST00000053597.3
    Conserved Domains (5) summary
    smart00082
    Location:234278
    LRRCT; Leucine rich repeat C-terminal domain
    COG4886
    Location:39205
    LRR; Leucine-rich repeat (LRR) protein [Transcription]
    sd00033
    Location:5073
    LRR_RI; leucine-rich repeat [structural motif]
    pfam00041
    Location:409478
    fn3; Fibronectin type III domain
    cl11960
    Location:295368
    Ig; Immunoglobulin domain