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Ptgr3 prostaglandin reductase 3 [ Mus musculus (house mouse) ]

Gene ID: 225791, updated on 12-Mar-2023

Summary

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Official Symbol
Ptgr3provided by MGI
Official Full Name
prostaglandin reductase 3provided by MGI
Primary source
MGI:MGI:2444835
See related
Ensembl:ENSMUSG00000049090 AllianceGenome:MGI:2444835
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Pthr3; Zadh2; PTGR-3; C530046K17Rik
Summary
Enables 13-prostaglandin reductase activity. Involved in negative regulation of fat cell differentiation. Located in peroxisome. Orthologous to human ZADH2 (zinc binding alcohol dehydrogenase domain containing 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in adrenal adult (RPKM 15.8), ovary adult (RPKM 15.6) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Ptgr3 in Genome Data Viewer
Location:
18; 18 E4
Exon count:
2
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (84106170..84115653)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (84088126..84097528)

Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 31792 Neighboring gene teashirt zinc finger family member 1 Neighboring gene predicted gene, 31854 Neighboring gene zinc finger protein 407 Neighboring gene uncharacterized LOC118568386

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Predicted mouse peroxisome-targeted proteins and their actual subcellular locations. Mizuno Y, et al. BMC Bioinformatics, 2008 Dec 12. PMID 19091015, Free PMC Article
  2. Prostaglandin reductase-3 negatively modulates adipogenesis through regulation of PPARγ activity. Yu YH, et al. J Lipid Res, 2013 Sep. PMID 23821743, Free PMC Article
  3. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article
  4. GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Visel A, et al. Nucleic Acids Res, 2004 Jan 1. PMID 14681479, Free PMC Article
  5. BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Pourhaghighi R, et al. Cell Syst, 2020 Apr 22. PMID 32325033, Free PMC Article

See all (17) citations in PubMed

See citations in PubMed for homologs of this gene provided by HomoloGene

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC32469

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 13-prostaglandin reductase activity IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
enables 13-prostaglandin reductase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables 15-oxoprostaglandin 13-oxidase activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within lipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of fat cell differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in mitochondrion HDA PubMed 
located_in peroxisome IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
prostaglandin reductase-3
Names
15-oxoprostaglandin 13-reductase
zinc binding alcohol dehydrogenase, domain containing 2
zinc-binding alcohol dehydrogenase domain-containing protein 2
NP_666202.2
XP_006526523.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001417837.1 → NP_001404766.1  prostaglandin reductase-3 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC124012

  2. NM_001417839.1 → NP_001404768.1  prostaglandin reductase-3 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC124012

  3. NM_001417840.1 → NP_001404769.1  prostaglandin reductase-3 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC124012

  4. NM_146090.6 → NP_666202.2  prostaglandin reductase-3 isoform 1

    See identical proteins and their annotated locations for NP_666202.2

    Status: VALIDATED

    Source sequence(s)
    AC124012
    Consensus CDS
    CCDS29381.1
    UniProtKB/Swiss-Prot
    Q8BGC4
    UniProtKB/TrEMBL
    Q14AZ9
    Related
    ENSMUSP00000052544.3, ENSMUST00000060223.4
    Conserved Domains (2) summary
    cd08250
    Location:32 → 368
    Mgc45594_like; Mgc45594 gene product and other MDR family members
    COG0604
    Location:33 → 368
    Qor; NADPH:quinone reductase or related Zn-dependent oxidoreductase [Energy production and conversion, General function prediction only]

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000084.7 Reference GRCm39 C57BL/6J

    Range
    84106170..84115653
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006526460.5 → XP_006526523.1  prostaglandin reductase-3 isoform X1

    UniProtKB/TrEMBL
    A0A494BB38
    Related
    ENSMUSP00000158299.2, ENSMUST00000235383.2
    Conserved Domains (1) summary
    cl16912
    Location:1 → 245
    MDR; Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BGC4.1 GenPept UniProtKB/Swiss-Prot:Q8BGC4

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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