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Rnf165 ring finger protein 165 [ Mus musculus (house mouse) ]

Gene ID: 225743, updated on 26-Sep-2022

Summary

Official Symbol
Rnf165provided by MGI
Official Full Name
ring finger protein 165provided by MGI
Primary source
MGI:MGI:2444521
See related
Ensembl:ENSMUSG00000025427 AllianceGenome:MGI:2444521
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Akd2; Gm96; Ark2c; 2900024M11Rik; G630064H08Rik
Summary
Enables ubiquitin protein ligase activity. Acts upstream of or within several processes, including forelimb morphogenesis; nervous system development; and positive regulation of BMP signaling pathway. Located in nucleus. Part of protein-containing complex. Is expressed in embryo. Orthologous to human RNF165 (ring finger protein 165). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in whole brain E14.5 (RPKM 11.0), CNS E14 (RPKM 9.2) and 7 other tissues See more
Orthologs
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Genomic context

See Rnf165 in Genome Data Viewer
Location:
18; 18 E3
Exon count:
9
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (77543806..77652832, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (77456110..77565136, complement)

Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene lipoxygenase homology domains 1 Neighboring gene USP6 N-terminal like pseudogene Neighboring gene RIKEN cDNA 8030462N17 gene Neighboring gene predicted gene, 41784 Neighboring gene predicted gene, 26014

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1)  1 citation
  • Endonuclease-mediated (2) 

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables ubiquitin protein ligase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
part_of protein-containing complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
E3 ubiquitin-protein ligase RNF165
Names
arkadia 2
arkadia-like protein 2C
NP_001157976.1
XP_036017022.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001164504.1NP_001157976.1  E3 ubiquitin-protein ligase RNF165

    See identical proteins and their annotated locations for NP_001157976.1

    Status: VALIDATED

    Source sequence(s)
    AC102135, BB619563, BC066016, BY256046, BY279218, BY727947, CF745657
    Consensus CDS
    CCDS50327.1
    UniProtKB/Swiss-Prot
    E9QAU8, Q3UZA7
    Related
    ENSMUSP00000026494.7, ENSMUST00000026494.14
    Conserved Domains (2) summary
    pfam07573
    Location:3084
    AreA_N; Nitrogen regulatory protein AreA N terminus
    pfam13639
    Location:295336
    zf-RING_2; Ring finger domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000084.7 Reference GRCm39 C57BL/6J

    Range
    77543806..77652832 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036161129.1XP_036017022.1  E3 ubiquitin-protein ligase RNF165 isoform X1

    Conserved Domains (1) summary
    cd16474
    Location:226271
    RING-H2_RNF111_like; RING finger, H2 subclass, found in RING finger proteins RNF111, RNF165, and similar proteins