Format

Send to:

Choose Destination

Mapk4 mitogen-activated protein kinase 4 [ Mus musculus (house mouse) ]

Gene ID: 225724, updated on 31-Jan-2019

Summary

Official Symbol
Mapk4provided by MGI
Official Full Name
mitogen-activated protein kinase 4provided by MGI
Primary source
MGI:MGI:2444559
See related
Ensembl:ENSMUSG00000024558
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Erk3; Prkm4; p63Mapk; A330097D03Rik
Expression
Broad expression in frontal lobe adult (RPKM 8.4), cortex adult (RPKM 7.3) and 18 other tissues See more
Orthologs

Genomic context

See Mapk4 in Genome Data Viewer
Location:
18; 18 E2
Exon count:
9
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 18 NC_000084.6 (73928486..74065120, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 18 NC_000084.5 (74088140..74224603, complement)

Chromosome 18 - NC_000084.6Genomic Context describing neighboring genes Neighboring gene predicted gene, 46631 Neighboring gene predicted gene, 32661 Neighboring gene maestro Neighboring gene RIKEN cDNA D730045A05 gene Neighboring gene predicted gene 9925 Neighboring gene predicted gene, 32801 Neighboring gene spindle and kinetochore associated complex subunit 1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
MAP kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
kinase activity IEA
Inferred from Electronic Annotation
more info
 
nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
protein heterodimerization activity IPI
Inferred from Physical Interaction
more info
PubMed 
protein homodimerization activity IDA
Inferred from Direct Assay
more info
PubMed 
protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
protein kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
 
transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
cell cycle IEA
Inferred from Electronic Annotation
more info
 
cellular response to organic substance IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
phosphorylation IEA
Inferred from Electronic Annotation
more info
 
protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 
regulation of gene expression IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
mitogen-activated protein kinase 4
Names
ERK-4
Erk3-related
MAP kinase 4
MAPK 4
extracellular signal-regulated kinase 4
NP_766220.2
XP_006525963.1
XP_006525964.1
XP_017173380.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001360936.1NP_001347865.1  mitogen-activated protein kinase 4 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC124367
    Conserved Domains (1) summary
    cl21453
    Location:2172
    PKc_like; Protein Kinases, catalytic domain
  2. NM_172632.2NP_766220.2  mitogen-activated protein kinase 4 isoform 1

    See identical proteins and their annotated locations for NP_766220.2

    Status: VALIDATED

    Source sequence(s)
    BC058942, BC094564, CB526503
    Consensus CDS
    CCDS37856.1
    UniProtKB/Swiss-Prot
    Q6P5G0
    Related
    ENSMUSP00000089462.3, ENSMUST00000091851.9
    Conserved Domains (2) summary
    cd07854
    Location:14351
    STKc_MAPK4_6; Catalytic domain of the Serine/Threonine Kinases, Mitogen-Activated Protein Kinases 4 (also called ERK4) and 6 (also called ERK3)
    pfam00069
    Location:20312
    Pkinase; Protein kinase domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000084.6 Reference GRCm38.p4 C57BL/6J

    Range
    73928486..74065120 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006525901.3XP_006525964.1  mitogen-activated protein kinase 4 isoform X1

    See identical proteins and their annotated locations for XP_006525964.1

    UniProtKB/Swiss-Prot
    Q6P5G0
    Conserved Domains (2) summary
    cd07854
    Location:14351
    STKc_MAPK4_6; Catalytic domain of the Serine/Threonine Kinases, Mitogen-Activated Protein Kinases 4 (also called ERK4) and 6 (also called ERK3)
    pfam00069
    Location:20312
    Pkinase; Protein kinase domain
  2. XM_006525900.3XP_006525963.1  mitogen-activated protein kinase 4 isoform X1

    See identical proteins and their annotated locations for XP_006525963.1

    UniProtKB/Swiss-Prot
    Q6P5G0
    Conserved Domains (2) summary
    cd07854
    Location:14351
    STKc_MAPK4_6; Catalytic domain of the Serine/Threonine Kinases, Mitogen-Activated Protein Kinases 4 (also called ERK4) and 6 (also called ERK3)
    pfam00069
    Location:20312
    Pkinase; Protein kinase domain
  3. XM_017317891.1XP_017173380.1  mitogen-activated protein kinase 4 isoform X2

    Conserved Domains (1) summary
    cl21453
    Location:2172
    PKc_like; Protein Kinases, catalytic domain
Support Center