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MAPK15 mitogen-activated protein kinase 15 [ Homo sapiens (human) ]

Gene ID: 225689, updated on 25-Jan-2022

Summary

Official Symbol
MAPK15provided by HGNC
Official Full Name
mitogen-activated protein kinase 15provided by HGNC
Primary source
HGNC:HGNC:24667
See related
Ensembl:ENSG00000181085 MIM:618616; AllianceGenome:HGNC:24667
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ERK7; ERK8
Summary
Enables MAP kinase activity and chromatin binding activity. Involved in several processes, including dopamine uptake; positive regulation of DNA metabolic process; and regulation of organelle organization. Located in several cellular components, including Golgi apparatus; autophagosome; and microtubule organizing center. Biomarker of breast cancer. [provided by Alliance of Genome Resources, Nov 2021]
Expression
Biased expression in lung (RPKM 5.3), testis (RPKM 4.6) and 9 other tissues See more
Orthologs
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Genomic context

See MAPK15 in Genome Data Viewer
Location:
8q24.3
Exon count:
14
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 8 NC_000008.11 (143716305..143722458)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (144798519..144804628)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 2878 Neighboring gene uncharacterized LOC101928160 Neighboring gene coiled-coil domain containing 166 Neighboring gene family with sequence similarity 83 member H Neighboring gene Sharpr-MPRA regulatory region 4007 Neighboring gene microRNA 4664

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
EBI GWAS Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 gp120 binding to CD4 results in activation of the mitogen-activated protein kinase (MAPK) in CD4(+) lymphocytes prestimulated through their T-cell receptor (TCR) PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables MAP kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables MAP kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables SH3 domain binding NAS
Non-traceable Author Statement
more info
PubMed 
enables chromatin binding IDA
Inferred from Direct Assay
more info
PubMed 
enables kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein serine/threonine/tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in MAPK cascade IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to DNA damage stimulus IDA
Inferred from Direct Assay
more info
PubMed 
involved_in dopamine uptake IDA
Inferred from Direct Assay
more info
PubMed 
involved_in endoplasmic reticulum organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in negative regulation of cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of cell population proliferation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of cell population proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of metaphase/anaphase transition of meiosis I IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of spindle assembly IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of telomerase activity IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of telomerase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of telomere capping IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of telomere capping IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of telomere maintenance via telomerase IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of telomere maintenance via telomerase IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein autophosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein localization to ciliary transition zone IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of COPII vesicle coating IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of autophagy IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of cilium assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of cilium assembly ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
PubMed 
located_in autophagosome IDA
Inferred from Direct Assay
more info
PubMed 
NOT located_in axoneme IDA
Inferred from Direct Assay
more info
PubMed 
located_in bicellular tight junction IEA
Inferred from Electronic Annotation
more info
 
located_in cell-cell junction IDA
Inferred from Direct Assay
more info
PubMed 
located_in centriole IDA
Inferred from Direct Assay
more info
PubMed 
located_in ciliary basal body IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
 
located_in extracellular region NAS
Non-traceable Author Statement
more info
PubMed 
located_in meiotic spindle IEA
Inferred from Electronic Annotation
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
mitogen-activated protein kinase 15
Names
ERK-7
ERK-8
MAP kinase 15
MAPK 15
extracellular regulated kinase 8 delta
extracellular signal-regulated kinase 7
extracellular signal-regulated kinase 8
NP_620590.2
XP_011515227.1
XP_011515228.1
XP_011515229.1
XP_011515230.1
XP_016868707.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_139021.3NP_620590.2  mitogen-activated protein kinase 15

    See identical proteins and their annotated locations for NP_620590.2

    Status: VALIDATED

    Source sequence(s)
    AY065978, BP357805
    Consensus CDS
    CCDS6409.2
    UniProtKB/Swiss-Prot
    Q8TD08
    Related
    ENSP00000337691.4, ENST00000338033.9
    Conserved Domains (2) summary
    smart00220
    Location:13304
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd07852
    Location:5343
    STKc_MAPK15-like; Catalytic domain of the Serine/Threonine Kinase, Mitogen-Activated Protein Kinase 15 and similar MAPKs

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p13 Primary Assembly

    Range
    143716305..143722458
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011516926.2XP_011515228.1  mitogen-activated protein kinase 15 isoform X2

    See identical proteins and their annotated locations for XP_011515228.1

    Conserved Domains (2) summary
    smart00220
    Location:13323
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd07852
    Location:5362
    STKc_MAPK15-like; Catalytic domain of the Serine/Threonine Kinase, Mitogen-Activated Protein Kinase 15 and similar MAPKs
  2. XM_011516925.2XP_011515227.1  mitogen-activated protein kinase 15 isoform X1

    See identical proteins and their annotated locations for XP_011515227.1

    Conserved Domains (2) summary
    smart00220
    Location:25325
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd07852
    Location:25364
    STKc_MAPK15-like; Catalytic domain of the Serine/Threonine Kinase, Mitogen-Activated Protein Kinase 15 and similar MAPKs
  3. XM_017013218.1XP_016868707.1  mitogen-activated protein kinase 15 isoform X4

  4. XM_011516927.2XP_011515229.1  mitogen-activated protein kinase 15 isoform X3

    See identical proteins and their annotated locations for XP_011515229.1

    Conserved Domains (2) summary
    smart00220
    Location:25306
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd07852
    Location:25345
    STKc_MAPK15-like; Catalytic domain of the Serine/Threonine Kinase, Mitogen-Activated Protein Kinase 15 and similar MAPKs
  5. XM_011516928.2XP_011515230.1  mitogen-activated protein kinase 15 isoform X5

    See identical proteins and their annotated locations for XP_011515230.1

    Conserved Domains (2) summary
    smart00220
    Location:25325
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd07852
    Location:25327
    STKc_MAPK15-like; Catalytic domain of the Serine/Threonine Kinase, Mitogen-Activated Protein Kinase 15 and similar MAPKs

RNA

  1. XR_001745494.1 RNA Sequence

  2. XR_001745493.1 RNA Sequence

Reference GRCh38.p13 ALT_REF_LOCI_1

Genomic

  1. NT_187571.1 Reference GRCh38.p13 ALT_REF_LOCI_1

    Range
    193396..199505
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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