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MAPK15 mitogen-activated protein kinase 15 [ Homo sapiens (human) ]

Gene ID: 225689, updated on 18-Nov-2018

Summary

Official Symbol
MAPK15provided by HGNC
Official Full Name
mitogen-activated protein kinase 15provided by HGNC
Primary source
HGNC:HGNC:24667
See related
Ensembl:ENSG00000181085 Vega:OTTHUMG00000146450
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ERK7; ERK8
Expression
Biased expression in lung (RPKM 5.3), testis (RPKM 4.6) and 9 other tissues See more
Orthologs

Genomic context

See MAPK15 in Genome Data Viewer
Location:
chromosome: 8
Exon count:
15
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 8 NC_000008.11 (143716305..143722463)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (144798507..144804633)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene breast cancer estrogen-induced apoptosis 2 Neighboring gene uncharacterized LOC101928160 Neighboring gene coiled-coil domain containing 166 Neighboring gene family with sequence similarity 83 member H Neighboring gene FAM83H antisense RNA 1 (head to head) Neighboring gene microRNA 4664

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
NHGRI GWA Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 gp120 binding to CD4 results in activation of the mitogen-activated protein kinase (MAPK) in CD4(+) lymphocytes prestimulated through their T-cell receptor (TCR) PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

  • IL-17 signaling pathway, organism-specific biosystem (from KEGG)
    IL-17 signaling pathway, organism-specific biosystemThe interleukin 17 (IL-17) family, a subset of cytokines consisting of IL-17A-F, plays crucial roles in both acute and chronic inflammatory responses. IL-17A, the hallmark cytokine of the newly defi...
  • IL-17 signaling pathway, conserved biosystem (from KEGG)
    IL-17 signaling pathway, conserved biosystemThe interleukin 17 (IL-17) family, a subset of cytokines consisting of IL-17A-F, plays crucial roles in both acute and chronic inflammatory responses. IL-17A, the hallmark cytokine of the newly defi...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
MAP kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
MAP kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
SH3 domain binding NAS
Non-traceable Author Statement
more info
PubMed 
chromatin binding IDA
Inferred from Direct Assay
more info
PubMed 
kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
MAPK cascade IEA
Inferred from Electronic Annotation
more info
 
cellular response to DNA damage stimulus IDA
Inferred from Direct Assay
more info
PubMed 
dopamine uptake IDA
Inferred from Direct Assay
more info
PubMed 
endoplasmic reticulum organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of metaphase/anaphase transition of meiosis I IEA
Inferred from Electronic Annotation
more info
 
positive regulation of spindle assembly IEA
Inferred from Electronic Annotation
more info
 
positive regulation of telomerase activity IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of telomerase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of telomere capping IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of telomere capping IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of telomere maintenance via telomerase IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of telomere maintenance via telomerase IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein autophosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
protein localization to ciliary transition zone IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of COPII vesicle coating IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of autophagy IDA
Inferred from Direct Assay
more info
PubMed 
regulation of cilium assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of cilium assembly ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of gene expression IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
Golgi apparatus IDA
Inferred from Direct Assay
more info
PubMed 
autophagosome IDA
Inferred from Direct Assay
more info
PubMed 
NOT axoneme IDA
Inferred from Direct Assay
more info
PubMed 
bicellular tight junction IEA
Inferred from Electronic Annotation
more info
 
cell-cell junction IDA
Inferred from Direct Assay
more info
PubMed 
centriole IDA
Inferred from Direct Assay
more info
PubMed 
ciliary basal body IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
 
extracellular region NAS
Non-traceable Author Statement
more info
PubMed 
meiotic spindle IEA
Inferred from Electronic Annotation
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
mitogen-activated protein kinase 15
Names
ERK-7
ERK-8
MAP kinase 15
MAPK 15
extracellular regulated kinase 8 delta
extracellular signal-regulated kinase 7
extracellular signal-regulated kinase 8
NP_620590.2
XP_011515227.1
XP_011515228.1
XP_011515229.1
XP_011515230.1
XP_016868707.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_139021.2NP_620590.2  mitogen-activated protein kinase 15

    See identical proteins and their annotated locations for NP_620590.2

    Status: VALIDATED

    Source sequence(s)
    AY065978, BP357805
    Consensus CDS
    CCDS6409.2
    UniProtKB/Swiss-Prot
    Q8TD08
    Related
    ENSP00000337691.4, OTTHUMP00000189334, ENST00000338033.8, OTTHUMT00000300348
    Conserved Domains (2) summary
    smart00220
    Location:13304
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd07852
    Location:5343
    STKc_MAPK15-like; Catalytic domain of the Serine/Threonine Kinase, Mitogen-Activated Protein Kinase 15 and similar MAPKs

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p12 Primary Assembly

    Range
    143716305..143722463
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011516926.2XP_011515228.1  mitogen-activated protein kinase 15 isoform X2

    See identical proteins and their annotated locations for XP_011515228.1

    Conserved Domains (2) summary
    smart00220
    Location:13323
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd07852
    Location:5362
    STKc_MAPK15-like; Catalytic domain of the Serine/Threonine Kinase, Mitogen-Activated Protein Kinase 15 and similar MAPKs
  2. XM_011516925.2XP_011515227.1  mitogen-activated protein kinase 15 isoform X1

    See identical proteins and their annotated locations for XP_011515227.1

    Conserved Domains (2) summary
    smart00220
    Location:25325
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd07852
    Location:25364
    STKc_MAPK15-like; Catalytic domain of the Serine/Threonine Kinase, Mitogen-Activated Protein Kinase 15 and similar MAPKs
  3. XM_017013218.1XP_016868707.1  mitogen-activated protein kinase 15 isoform X4

  4. XM_011516927.2XP_011515229.1  mitogen-activated protein kinase 15 isoform X3

    See identical proteins and their annotated locations for XP_011515229.1

    Conserved Domains (2) summary
    smart00220
    Location:25306
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd07852
    Location:25345
    STKc_MAPK15-like; Catalytic domain of the Serine/Threonine Kinase, Mitogen-Activated Protein Kinase 15 and similar MAPKs
  5. XM_011516928.2XP_011515230.1  mitogen-activated protein kinase 15 isoform X5

    See identical proteins and their annotated locations for XP_011515230.1

    Conserved Domains (2) summary
    smart00220
    Location:25325
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd07852
    Location:25327
    STKc_MAPK15-like; Catalytic domain of the Serine/Threonine Kinase, Mitogen-Activated Protein Kinase 15 and similar MAPKs

RNA

  1. XR_001745494.1 RNA Sequence

  2. XR_001745493.1 RNA Sequence

Reference GRCh38.p12 ALT_REF_LOCI_1

Genomic

  1. NT_187571.1 Reference GRCh38.p12 ALT_REF_LOCI_1

    Range
    193384..199510
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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