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Grp gastrin releasing peptide [ Mus musculus (house mouse) ]

Gene ID: 225642, updated on 8-Feb-2024

Summary

Official Symbol
Grpprovided by MGI
Official Full Name
gastrin releasing peptideprovided by MGI
Primary source
MGI:MGI:95833
See related
Ensembl:ENSMUSG00000024517 AllianceGenome:MGI:95833
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
BLP
Summary
This gene encodes a neuropeptide hormone that affects various biological processes such as neuroendocrine regulation, gastrointestinal secretion, nociception, cell proliferation and inflammation. The encoded protein undergoes proteolytic processing to generate multiple mature peptides with biological activity. [provided by RefSeq, Aug 2015]
Expression
Biased expression in stomach adult (RPKM 3.4), CNS E18 (RPKM 3.1) and 11 other tissues See more
Orthologs
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Genomic context

See Grp in Genome Data Viewer
Location:
18 E1; 18 38.98 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (66005826..66019670)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (65872751..65886599)

Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr18:65960619-65960728 Neighboring gene STARR-positive B cell enhancer ABC_E1517 Neighboring gene STARR-positive B cell enhancer ABC_E9984 Neighboring gene STARR-positive B cell enhancer ABC_E1961 Neighboring gene SEC11 homolog C, signal peptidase complex subunit Neighboring gene STARR-seq mESC enhancer starr_44853 Neighboring gene predicted gene, 52375 Neighboring gene predicted gene, 30094 Neighboring gene predicted gene, 25150 Neighboring gene STARR-seq mESC enhancer starr_44855 Neighboring gene STARR-positive B cell enhancer ABC_E7598 Neighboring gene retina and anterior neural fold homeobox

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (5)  1 citation
  • Endonuclease-mediated (5) 

Pathways from PubChem

General gene information

Markers

Clone Names

  • MGC37475

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables neuropeptide hormone activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables neuropeptide hormone activity ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in cell projection IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
 
located_in extracellular region ISO
Inferred from Sequence Orthology
more info
 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
 
located_in neuron projection IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in neuronal dense core vesicle ISO
Inferred from Sequence Orthology
more info
 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_175012.4NP_778177.1  gastrin-releasing peptide preproprotein

    See identical proteins and their annotated locations for NP_778177.1

    Status: REVIEWED

    Source sequence(s)
    AK133508, AK139345, BE944748
    Consensus CDS
    CCDS29310.1
    UniProtKB/Swiss-Prot
    Q3UTL2, Q8R1I2
    Related
    ENSMUSP00000025395.9, ENSMUST00000025395.10
    Conserved Domains (1) summary
    pfam02044
    Location:4356
    Bombesin; Bombesin-like peptide

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000084.7 Reference GRCm39 C57BL/6J

    Range
    66005826..66019670
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006525886.5XP_006525949.1  gastrin-releasing peptide isoform X1

    See identical proteins and their annotated locations for XP_006525949.1

    UniProtKB/Swiss-Prot
    Q3UTL2, Q8R1I2
    Related
    ENSMUSP00000133437.2, ENSMUST00000173985.10
    Conserved Domains (1) summary
    pfam02044
    Location:4356
    Bombesin; Bombesin-like peptide
  2. XM_006525887.4XP_006525950.1  gastrin-releasing peptide isoform X2

    Conserved Domains (1) summary
    pfam02044
    Location:4356
    Bombesin; Bombesin-like peptide