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Onecut2 one cut domain, family member 2 [ Mus musculus (house mouse) ]

Gene ID: 225631, updated on 13-Feb-2024

Summary

Official Symbol
Onecut2provided by MGI
Official Full Name
one cut domain, family member 2provided by MGI
Primary source
MGI:MGI:1891408
See related
Ensembl:ENSMUSG00000045991 AllianceGenome:MGI:1891408
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Oc2; OC-2; C730009D12
Summary
Enables DNA-binding transcription factor activity and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within several processes, including liver development; negative regulation of transforming growth factor beta receptor signaling pathway; and peripheral nervous system neuron development. Predicted to be located in actin cytoskeleton and nucleoplasm. Predicted to be active in nucleus. Is expressed in several structures, including central nervous system; future brain; genitourinary system; gut; and retina. Orthologous to human ONECUT2 (one cut homeobox 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in liver adult (RPKM 3.0), duodenum adult (RPKM 1.9) and 11 other tissues See more
Orthologs
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Genomic context

See Onecut2 in Genome Data Viewer
Location:
18 E1; 18 37.33 cM
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (64473098..64531559)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (64340032..64398488)

Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 3, opposite strand Neighboring gene ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 3 Neighboring gene ribosomal protein S15, pseudogene 3 Neighboring gene STARR-seq mESC enhancer starr_44803 Neighboring gene STARR-seq mESC enhancer starr_44804 Neighboring gene STARR-seq mESC enhancer starr_44805 Neighboring gene STARR-seq mESC enhancer starr_44806 Neighboring gene predicted gene, 36804 Neighboring gene S-adenosylmethionine decarboxylase, pseudogene 3

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2)  1 citation
  • Endonuclease-mediated (2) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC124203

Gene Ontology Provided by MGI

Process Evidence Code Pubs
acts_upstream_of_or_within anatomical structure morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within cell fate commitment IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of cell migration IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within cilium assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within endocrine pancreas development IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within epithelial cell development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within liver development IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of mesenchymal stem cell migration IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within negative regulation of transforming growth factor beta receptor signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within pancreas development IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within peripheral nervous system neuron development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of mesenchymal stem cell migration IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of cell-matrix adhesion IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of transforming growth factor beta receptor signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in actin cytoskeleton ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus IC
Inferred by Curator
more info
PubMed 

General protein information

Preferred Names
one cut domain family member 2
Names
one cut homeobox 2
transcription factor ONECUT-2
transcription factor ONECUT2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_194268.3NP_919244.2  one cut domain family member 2

    See identical proteins and their annotated locations for NP_919244.2

    Status: VALIDATED

    Source sequence(s)
    AC102106
    Consensus CDS
    CCDS29302.2
    UniProtKB/Swiss-Prot
    Q6XBJ3
    UniProtKB/TrEMBL
    Q3ZAT5
    Related
    ENSMUSP00000135692.3, ENSMUST00000175965.10
    Conserved Domains (2) summary
    smart00389
    Location:427482
    HOX; Homeodomain
    pfam02376
    Location:332404
    CUT; CUT domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000084.7 Reference GRCm39 C57BL/6J

    Range
    64473098..64531559
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030250441.1XP_030106301.1  one cut domain family member 2 isoform X1

    Conserved Domains (1) summary
    pfam02376
    Location:332400
    CUT; CUT domain