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FGF7 fibroblast growth factor 7 [ Homo sapiens (human) ]

Gene ID: 2252, updated on 21-Jun-2020

Summary

Official Symbol
FGF7provided by HGNC
Official Full Name
fibroblast growth factor 7provided by HGNC
Primary source
HGNC:HGNC:3685
See related
Ensembl:ENSG00000140285 MIM:148180
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
KGF; HBGF-7
Summary
The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This protein is a potent epithelial cell-specific growth factor, whose mitogenic activity is predominantly exhibited in keratinocytes but not in fibroblasts and endothelial cells. Studies of mouse and rat homologs of this gene implicated roles in morphogenesis of epithelium, reepithelialization of wounds, hair development and early lung organogenesis. [provided by RefSeq, Jul 2008]
Expression
Broad expression in gall bladder (RPKM 32.8), urinary bladder (RPKM 19.9) and 15 other tissues See more
Orthologs

Genomic context

See FGF7 in Genome Data Viewer
Location:
15q21.2
Exon count:
4
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 15 NC_000015.10 (49423242..49488775)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (49715375..49779523)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene galactokinase 2 Neighboring gene RNA, 7SL, cytoplasmic 307, pseudogene Neighboring gene family with sequence similarity 227 member B Neighboring gene signal peptide peptidase like 2A pseudogene Neighboring gene uncharacterized LOC105370811 Neighboring gene DTW domain containing 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
A meta-analysis of thyroid-related traits reveals novel loci and gender-specific differences in the regulation of thyroid function.
NHGRI GWA Catalog
Genome-wide association study identifies four genetic loci associated with thyroid volume and goiter risk.
NHGRI GWA Catalog

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of fibroblast growth factor 7 (FGF7) by shRNA library screening inhibits HIV-1 replication in cultured Jurkat T-cells PubMed

Protein interactions

Protein Gene Interaction Pubs
Tat tat Microarray analysis indicates HIV-1 Tat-induced upregulation of fibroblast growth factor 7 (FGF7; KGF: keratinocyte growth factor) in primary human brain microvascular endothelial cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
chemoattractant activity IDA
Inferred from Direct Assay
more info
PubMed 
fibroblast growth factor receptor binding IEA
Inferred from Electronic Annotation
more info
 
growth factor activity IEA
Inferred from Electronic Annotation
more info
 
heparin binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
MAPK cascade TAS
Traceable Author Statement
more info
 
actin cytoskeleton reorganization IDA
Inferred from Direct Assay
more info
PubMed 
branching involved in salivary gland morphogenesis IEA
Inferred from Electronic Annotation
more info
 
epidermis development TAS
Traceable Author Statement
more info
PubMed 
fibroblast growth factor receptor signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
fibroblast growth factor receptor signaling pathway TAS
Traceable Author Statement
more info
 
hair follicle morphogenesis IEA
Inferred from Electronic Annotation
more info
 
mesenchymal cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
positive chemotaxis IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of cell division IEA
Inferred from Electronic Annotation
more info
 
positive regulation of cell proliferation IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of epithelial cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of epithelial cell proliferation involved in lung morphogenesis IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of keratinocyte migration IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of keratinocyte proliferation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of peptidyl-tyrosine phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of protein kinase B signaling TAS
Traceable Author Statement
more info
 
positive regulation of transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
protein localization to cell surface IDA
Inferred from Direct Assay
more info
PubMed 
regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling IEA
Inferred from Electronic Annotation
more info
 
response to wounding TAS
Traceable Author Statement
more info
PubMed 
secretion by lung epithelial cell involved in lung growth IDA
Inferred from Direct Assay
more info
PubMed 
signal transduction NAS
Non-traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
Golgi apparatus IEA
Inferred from Electronic Annotation
more info
 
extracellular region TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
fibroblast growth factor 7
Names
FGF-7
heparin-binding growth factor 7
keratinocyte growth factor

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029159.1 RefSeqGene

    Range
    5065..70598
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_002009.4NP_002000.1  fibroblast growth factor 7 precursor

    See identical proteins and their annotated locations for NP_002000.1

    Status: REVIEWED

    Source sequence(s)
    AC025919, DB206350, M60828
    Consensus CDS
    CCDS10131.1
    UniProtKB/Swiss-Prot
    P21781
    Related
    ENSP00000267843.4, ENST00000267843.9
    Conserved Domains (1) summary
    smart00442
    Location:63191
    FGF; Acidic and basic fibroblast growth factor family

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p13 Primary Assembly

    Range
    49423242..49488775
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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