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Fbxo11 F-box protein 11 [ Mus musculus (house mouse) ]

Gene ID: 225055, updated on 18-Apr-2024

Summary

Official Symbol
Fbxo11provided by MGI
Official Full Name
F-box protein 11provided by MGI
Primary source
MGI:MGI:2147134
See related
Ensembl:ENSMUSG00000005371 AllianceGenome:MGI:2147134
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Jf
Summary
Enables ubiquitin-protein transferase activity. Involved in sensory perception of sound. Predicted to be located in cytosol; nucleolus; and nucleoplasm. Predicted to be part of ubiquitin ligase complex. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system; and respiratory system. Used to study otitis media. Orthologous to human FBXO11 (F-box protein 11). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E14 (RPKM 23.5), whole brain E14.5 (RPKM 20.3) and 28 other tissues See more
Orthologs
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Genomic context

Location:
17 E4; 17 57.87 cM
Exon count:
25
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (88298287..88373473, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (87990859..88066045, complement)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_43521 Neighboring gene predicted gene, 41649 Neighboring gene STARR-seq mESC enhancer starr_43523 Neighboring gene STARR-seq mESC enhancer starr_43524 Neighboring gene STARR-seq mESC enhancer starr_43525 Neighboring gene STARR-seq mESC enhancer starr_43526 Neighboring gene STARR-seq mESC enhancer starr_43527 Neighboring gene ribosomal protein L36, pseudogene 4 Neighboring gene STARR-seq mESC enhancer starr_43528 Neighboring gene STARR-seq mESC enhancer starr_43529 Neighboring gene STARR-seq mESC enhancer starr_43530 Neighboring gene STARR-positive B cell enhancer ABC_E9446 Neighboring gene STARR-seq mESC enhancer starr_43533 Neighboring gene STARR-positive B cell enhancer ABC_E7566 Neighboring gene mutS homolog 6 Neighboring gene STARR-positive B cell enhancer ABC_E8701 Neighboring gene STARR-positive B cell enhancer ABC_E4235 Neighboring gene STARR-positive B cell enhancer ABC_E5642 Neighboring gene STARR-positive B cell enhancer mm9_chr17:88465439-88465740 Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:88465818-88465927 Neighboring gene STARR-seq mESC enhancer starr_43538 Neighboring gene STARR-positive B cell enhancer ABC_E1513 Neighboring gene STARR-positive B cell enhancer ABC_E5643 Neighboring gene STARR-seq mESC enhancer starr_43539 Neighboring gene predicted gene 4832 Neighboring gene predicted gene, 31499

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC156416

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein-arginine N-methyltransferase activity ISO
Inferred from Sequence Orthology
more info
 
enables ubiquitin-protein transferase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in chromosome IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001081034.3NP_001074503.1  F-box only protein 11 isoform 1

    See identical proteins and their annotated locations for NP_001074503.1

    Status: VALIDATED

    Source sequence(s)
    AC087233, AC154673, AI853268, BC055343, BY127063, CA557033, CA749247, CF169182, CF172333, CN533292, CN666984
    Consensus CDS
    CCDS37717.1
    UniProtKB/Swiss-Prot
    A1A595, E9QP06, Q08EB9, Q08EC0, Q7TPD1, Q80UP0
    Related
    ENSMUSP00000005504.9, ENSMUST00000005504.15
    Conserved Domains (3) summary
    pfam12937
    Location:160203
    F-box-like; F-box-like
    pfam13229
    Location:667812
    Beta_helix; Right handed beta helix region
    cl19744
    Location:853894
    zf-UBR; Putative zinc finger in N-recognin (UBR box)
  2. NM_001348248.1NP_001335177.1  F-box only protein 11 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus compared to isoform 1.
    Source sequence(s)
    AC087233, AC154673, BC055343, BY127063, CA557033, CA749247, CF169182, CF172333, CN533292, CN666984
    UniProtKB/Swiss-Prot
    Q7TPD1
    Conserved Domains (3) summary
    pfam12937
    Location:73116
    F-box-like
    pfam13229
    Location:580739
    Beta_helix; Right handed beta helix region
    cl19744
    Location:766807
    zf-UBR; Putative zinc finger in N-recognin (UBR box)
  3. NM_001379303.1NP_001366232.1  F-box only protein 11 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC087233, AC154673
    Conserved Domains (3) summary
    pfam12937
    Location:159202
    F-box-like
    pfam13229
    Location:666825
    Beta_helix; Right handed beta helix region
    cl19744
    Location:852893
    zf-UBR; Putative zinc finger in N-recognin (UBR box)
  4. NM_001379304.1NP_001366233.1  F-box only protein 11 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC087233, AC154673
    Conserved Domains (3) summary
    pfam12937
    Location:73116
    F-box-like
    pfam13229
    Location:580739
    Beta_helix; Right handed beta helix region
    cl19744
    Location:766807
    zf-UBR; Putative zinc finger in N-recognin (UBR box)
  5. NM_001379305.1NP_001366234.1  F-box only protein 11 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC087233, AC154673
    Related
    ENSMUSP00000121206.3, ENSMUST00000130379.9
    Conserved Domains (3) summary
    pfam12937
    Location:72115
    F-box-like
    pfam13229
    Location:579738
    Beta_helix; Right handed beta helix region
    cl19744
    Location:765806
    zf-UBR; Putative zinc finger in N-recognin (UBR box)
  6. NM_001414440.1NP_001401369.1  F-box only protein 11 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC087233, AC154673

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    88298287..88373473 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)