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Dpp9 dipeptidylpeptidase 9 [ Mus musculus (house mouse) ]

Gene ID: 224897, updated on 29-May-2024

Summary

Official Symbol
Dpp9provided by MGI
Official Full Name
dipeptidylpeptidase 9provided by MGI
Primary source
MGI:MGI:2443967
See related
Ensembl:ENSMUSG00000001229 AllianceGenome:MGI:2443967
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
DPRP2; DPP IX; A330078I11; 6430584G11Rik
Summary
Predicted to enable dipeptidyl-peptidase activity and identical protein binding activity. Predicted to be located in cell leading edge; cytosol; and microtubule. Is expressed in several structures, including forelimb bud; gut; male reproductive gland or organ; myotome; and nervous system. Orthologous to human DPP9 (dipeptidyl peptidase 9). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in lung adult (RPKM 24.7), thymus adult (RPKM 22.1) and 28 other tissues See more
Orthologs
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Genomic context

See Dpp9 in Genome Data Viewer
Location:
17 D; 17 29.2 cM
Exon count:
22
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (56493674..56525927, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (56186674..56218889, complement)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6B Neighboring gene STARR-positive B cell enhancer ABC_E5621 Neighboring gene tumor necrosis factor, alpha-induced protein 8-like 1 Neighboring gene STARR-positive B cell enhancer ABC_E7547 Neighboring gene myeloid derived growth factor Neighboring gene RIKEN cDNA A230051N06 gene Neighboring gene microRNA 7b

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (4) 
  • Gene trapped (1) 
  • Targeted (5)  1 citation

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables aminopeptidase activity IEA
Inferred from Electronic Annotation
more info
 
enables dipeptidyl-peptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables dipeptidyl-peptidase activity ISO
Inferred from Sequence Orthology
more info
 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables peptidase activity IEA
Inferred from Electronic Annotation
more info
 
enables serine-type peptidase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in negative regulation of programmed cell death ISO
Inferred from Sequence Orthology
more info
 
involved_in proteolysis IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_negative_effect pyroptosis ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in cell leading edge ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
is_active_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in microtubule ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
dipeptidyl peptidase 9
Names
DP9
DPLP9
dipeptidyl peptidase IX
dipeptidyl peptidase-like protein 9
NP_001347213.1
NP_766212.2
XP_006524218.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001360284.1NP_001347213.1  dipeptidyl peptidase 9 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AC026385
    Conserved Domains (2) summary
    pfam00326
    Location:720921
    Peptidase_S9; Prolyl oligopeptidase family
    cl27623
    Location:204628
    DPPIV_N; Dipeptidyl peptidase IV (DPP IV) N-terminal region
  2. NM_172624.3NP_766212.2  dipeptidyl peptidase 9 isoform 2

    See identical proteins and their annotated locations for NP_766212.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate exon in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (2) has a distinct N-terminus and is shorter than isoform 1.
    Source sequence(s)
    AK050021, AK050023, AK078301
    Consensus CDS
    CCDS37663.1
    UniProtKB/Swiss-Prot
    Q6KAM9, Q8BVG4, Q8BWT9
    Related
    ENSMUSP00000046604.5, ENSMUST00000038794.6
    Conserved Domains (2) summary
    pfam00326
    Location:661862
    Peptidase_S9; Prolyl oligopeptidase family
    pfam00930
    Location:145568
    DPPIV_N; Dipeptidyl peptidase IV (DPP IV) N-terminal region

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    56493674..56525927 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006524155.5XP_006524218.1  dipeptidyl peptidase 9 isoform X1

    See identical proteins and their annotated locations for XP_006524218.1

    UniProtKB/Swiss-Prot
    Q6KAM9, Q8BVG4, Q8BWT9
    Conserved Domains (2) summary
    pfam00326
    Location:661862
    Peptidase_S9; Prolyl oligopeptidase family
    pfam00930
    Location:145568
    DPPIV_N; Dipeptidyl peptidase IV (DPP IV) N-terminal region

RNA

  1. XR_004939518.1 RNA Sequence

  2. XR_385319.4 RNA Sequence