U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Dpp9 dipeptidylpeptidase 9 [ Mus musculus (house mouse) ]

Gene ID: 224897, updated on 12-Apr-2023

Summary

Go to the top of the page Help
Official Symbol
Dpp9provided by MGI
Official Full Name
dipeptidylpeptidase 9provided by MGI
Primary source
MGI:MGI:2443967
See related
Ensembl:ENSMUSG00000001229 AllianceGenome:MGI:2443967
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
DPRP2; DPP IX; A330078I11; 6430584G11Rik
Summary
Predicted to enable dipeptidyl-peptidase activity and identical protein binding activity. Predicted to be located in cell leading edge; cytosol; and microtubule. Is expressed in several structures, including forelimb bud; gut; male reproductive gland or organ; myotome; and nervous system. Orthologous to human DPP9 (dipeptidyl peptidase 9). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in lung adult (RPKM 24.7), thymus adult (RPKM 22.1) and 28 other tissues See more
Orthologs
human all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Dpp9 in Genome Data Viewer
Location:
17; 17 D
Exon count:
22
Annotation release Status Assembly Chr Location
RS_2023_04 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (56493674..56525927, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (56186674..56218889, complement)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6B Neighboring gene tumor necrosis factor, alpha-induced protein 8-like 1 Neighboring gene myeloid derived growth factor Neighboring gene RIKEN cDNA A230051N06 gene Neighboring gene microRNA 7b

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. DPP9 enzymatic activity in hematopoietic cells is dispensable for mouse hematopoiesis. Kim M, et al. Immunol Lett, 2018 Jun. PMID 29709545
  2. Expression, subcellular localisation, and possible roles of dipeptidyl peptidase 9 (DPP9) in murine macrophages. Zapletal E, et al. Cell Biochem Funct, 2017 Mar. PMID 28256001
  3. Dipeptidyl peptidase 9 enzymatic activity influences the expression of neonatal metabolic genes. Chen Y, et al. Exp Cell Res, 2016 Mar 1. PMID 26930324
  4. Identification of novel dipeptidyl peptidase 9 substrates by two-dimensional differential in-gel electrophoresis. Zhang H, et al. FEBS J, 2015 Oct. PMID 26175140
  5. Targeted inactivation of dipeptidyl peptidase 9 enzymatic activity causes mouse neonate lethality. Gall MG, et al. PLoS One, 2013. PMID 24223149, Free PMC Article

See all (36) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. DPP9 deficiency: An inflammasomopathy that can be rescued by lowering NLRP1/IL-1 signaling.
    Title: DPP9 deficiency: An inflammasomopathy that can be rescued by lowering NLRP1/IL-1 signaling.
  2. Immune regeneration in irradiated mice is not impaired by the absence of DPP9 enzymatic activity.
    Title: Immune regeneration in irradiated mice is not impaired by the absence of DPP9 enzymatic activity.
  3. The effect of CD26-deficiency on dipeptidyl peptidase 8 and 9 expression profiles in a mouse model of Crohn's disease.
    Title: The effect of CD26-deficiency on dipeptidyl peptidase 8 and 9 expression profiles in a mouse model of Crohn's disease.
  4. Dipeptidyl peptidase 9 (DPP9) knock-in mice (DPP9(ki/ki) mice)express a catalytically inactive S729A mutant of DPP9 enzyme. DPP9(ki/ki) mice show reduced number of lymphoid and myeloid cells in fetal liver and postnatal blood but their hematopoietic cells are fully functional and able to reconstitute lymphoid and myeloid lineages even in competitive mixed chimeras.
    Title: DPP9 enzymatic activity in hematopoietic cells is dispensable for mouse hematopoiesis.
  5. lack of DPP9 activity in mice leads to impaired tongue development, suckling defect and subsequent neonatal lethality.
    Title: DPP9 enzyme activity controls survival of mouse migratory tongue muscle progenitors and its absence leads to neonatal lethality due to suckling defect.
  6. Changes induced by DPP9 gene silencing in macrophages suggest possible role of DPP9 in regulation of proliferation and activation status, as well as in peptide processing within endosomal/vesicular compartment.
    Title: Expression, subcellular localisation, and possible roles of dipeptidyl peptidase 9 (DPP9) in murine macrophages.
  7. DPP9 enzyme activity regulates metabolic pathways in neonatal liver and gut.
    Title: Dipeptidyl peptidase 9 enzymatic activity influences the expression of neonatal metabolic genes.
  8. Blocking the expression or activities of DPP8 and DPP9 attenuates PPARgamma2 induction during preadipocyte differentiation.
    Title: Inhibition of dipeptidyl peptidase 8/9 impairs preadipocyte differentiation.
  9. Identification of novel dipeptidyl peptidase 9 substrates: discovering dipeptide Val-Ala as a consensus site for DPP9 cleavage
    Title: Identification of novel dipeptidyl peptidase 9 substrates by two-dimensional differential in-gel electrophoresis.
  10. DPP9 enzymatic activity is essential for early neonatal survival in mice.
    Title: Targeted inactivation of dipeptidyl peptidase 9 enzymatic activity causes mouse neonate lethality.
Submit: New GeneRIF Correction See all GeneRIFs (12)

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (4)  1 citation
  • Endonuclease-mediated (3) 

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables aminopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables dipeptidyl-peptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
enables dipeptidyl-peptidase activity ISO
Inferred from Sequence Orthology
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables peptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables serine-type peptidase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in negative regulation of programmed cell death ISO
Inferred from Sequence Orthology
more info
  
involved_in proteolysis IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
acts_upstream_of_negative_effect pyroptosis ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cell leading edge ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in microtubule ISO
Inferred from Sequence Orthology
more info
  

General protein information

Go to the top of the page Help
Preferred Names
dipeptidyl peptidase 9
Names
DP9
DPLP9
dipeptidyl peptidase IX
dipeptidyl peptidase-like protein 9
NP_001347213.1
NP_766212.2
XP_006524218.1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001360284.1 → NP_001347213.1  dipeptidyl peptidase 9 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AC026385
    UniProtKB/TrEMBL
    A0A8C6H033
    Conserved Domains (2) summary
    pfam00326
    Location:720 → 921
    Peptidase_S9; Prolyl oligopeptidase family
    cl27623
    Location:204 → 628
    DPPIV_N; Dipeptidyl peptidase IV (DPP IV) N-terminal region

  2. NM_172624.3 → NP_766212.2  dipeptidyl peptidase 9 isoform 2

    See identical proteins and their annotated locations for NP_766212.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate exon in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (2) has a distinct N-terminus and is shorter than isoform 1.
    Source sequence(s)
    AK050021, AK050023, AK078301
    Consensus CDS
    CCDS37663.1
    UniProtKB/Swiss-Prot
    Q8BVG4, Q8BWT9
    Related
    ENSMUSP00000046604.5, ENSMUST00000038794.6
    Conserved Domains (2) summary
    pfam00326
    Location:661 → 862
    Peptidase_S9; Prolyl oligopeptidase family
    pfam00930
    Location:145 → 568
    DPPIV_N; Dipeptidyl peptidase IV (DPP IV) N-terminal region

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2023_04

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    56493674..56525927 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006524155.5 → XP_006524218.1  dipeptidyl peptidase 9 isoform X1

    See identical proteins and their annotated locations for XP_006524218.1

    UniProtKB/Swiss-Prot
    Q8BVG4, Q8BWT9
    Conserved Domains (2) summary
    pfam00326
    Location:661 → 862
    Peptidase_S9; Prolyl oligopeptidase family
    pfam00930
    Location:145 → 568
    DPPIV_N; Dipeptidyl peptidase IV (DPP IV) N-terminal region

RNA

  1. XR_004939518.1 RNA Sequence

  2. XR_385319.4 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BVG4.2 GenPept UniProtKB/Swiss-Prot:Q8BVG4

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous