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Plcl2 phospholipase C-like 2 [ Mus musculus (house mouse) ]

Gene ID: 224860, updated on 24-Sep-2025
Official Symbol
Plcl2provided by MGI
Official Full Name
phospholipase C-like 2provided by MGI
Primary source
MGI:MGI:1352756
See related
Ensembl:ENSMUSG00000038910 AllianceGenome:MGI:1352756
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Plce2; PLC-L2; PRIP-2; mKIAA1092
Summary
Predicted to enable GABA receptor binding activity and phosphatidylinositol-4,5-bisphosphate phospholipase C activity. Involved in negative regulation of cold-induced thermogenesis. Acts upstream of or within several processes, including B cell activation; gamma-aminobutyric acid signaling pathway; and negative regulation of B cell receptor signaling pathway. Predicted to be located in cytoplasm. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; nervous system; and sensory organ. Orthologous to human PLCL2 (phospholipase C like 2). [provided by Alliance of Genome Resources, Jul 2025]
Expression
Ubiquitous expression in cortex adult (RPKM 8.5), CNS E18 (RPKM 6.4) and 26 other tissues See more
Orthologs
human all
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See Plcl2 in Genome Data Viewer
Location:
17 C; 17 25.86 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (50815893..50995522)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (50508865..50688494)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 31015 Neighboring gene STARR-seq mESC enhancer starr_42795 Neighboring gene predicted gene, 30958 Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:50609750-50609937 Neighboring gene STARR-positive B cell enhancer ABC_E8684 Neighboring gene predicted gene, 54010 Neighboring gene STARR-positive B cell enhancer ABC_E7543 Neighboring gene STARR-seq mESC enhancer starr_42797 Neighboring gene STARR-seq mESC enhancer starr_42798 Neighboring gene STARR-seq mESC enhancer starr_42799 Neighboring gene B-cell translocation gene 3 pseudogene Neighboring gene TBC1 domain family, member 5 Neighboring gene predicted gene, 41598

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Related articles in PubMed

  1. Phospholipase C-related but catalytically inactive protein acts as a positive regulator of insulin signalling in adipocytes. Gao J, et al. J Cell Sci, 2022 Jan 1. PMID 34859819
  2. Role of phospholipase C-L2, a novel phospholipase C-like protein that lacks lipase activity, in B-cell receptor signaling. Takenaka K, et al. Mol Cell Biol, 2003 Oct. PMID 14517301, Free PMC Article
  3. Phospholipase C-related inactive protein is implicated in the constitutive internalization of GABAA receptors mediated by clathrin and AP2 adaptor complex. Kanematsu T, et al. J Neurochem, 2007 May. PMID 17254016
  4. Phospholipase C-related inactive protein is involved in trafficking of gamma2 subunit-containing GABA(A) receptors to the cell surface. Mizokami A, et al. J Neurosci, 2007 Feb 14. PMID 17301177, Free PMC Article
  5. Involvement of phospholipase C-related inactive protein in the mouse reproductive system through the regulation of gonadotropin levels. Matsuda M, et al. Biol Reprod, 2009 Oct. PMID 19553601

See all (40) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Phospholipase C-related catalytically inactive protein regulates lipopolysaccharide-induced hypothalamic inflammation-mediated anorexia in mice.
    Title: Phospholipase C-related catalytically inactive protein regulates lipopolysaccharide-induced hypothalamic inflammation-mediated anorexia in mice.
  2. These results suggest that PRIPs are positively involved in the development of follicles via their regulation of LH-LHR signaling and estradiol secretion.
    Title: Phospholipase C-related but catalytically inactive proteins regulate ovarian follicle development.
  3. Suppressed expression of PRIP-2 induces an elevated expression of KCC2 in the spinal cord, resulting in inhibition of nociception and amelioration of neuropathic pain in DKO mice.
    Title: Phospholipase C-related but catalytically inactive protein modulates pain behavior in a neuropathic pain model in mice.
  4. The results suggest that PRIP2 is involved in insulin-induced GABA(A) receptor insertion by recruiting active Akt to the receptor complex.
    Title: Phospholipase C-related but catalytically inactive protein is required for insulin-induced cell surface expression of gamma-aminobutyric acid type A receptors.
  5. PLC-L2 is a novel negative regulator of BCR signaling and immune responses
    Title: Role of phospholipase C-L2, a novel phospholipase C-like protein that lacks lipase activity, in B-cell receptor signaling.
Submit: New GeneRIF Correction

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (6) 
  • Targeted (1)  1 citation
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables GABA receptor binding IEA
Inferred from Electronic Annotation
more info
  
enables GABA receptor binding ISO
Inferred from Sequence Orthology
more info
 PubMed 
enables inositol 1,4,5 trisphosphate binding IEA
Inferred from Electronic Annotation
more info
  
enables phosphatidylinositol-4,5-bisphosphate phospholipase C activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphatidylinositol-4,5-bisphosphate phospholipase C activity IEA
Inferred from Electronic Annotation
more info
  
enables phosphoric diester hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within B cell proliferation involved in immune response IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within B-1a B cell differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in gamma-aminobutyric acid signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in gamma-aminobutyric acid signaling pathway IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within gamma-aminobutyric acid signaling pathway IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
  
involved_in lipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within negative regulation of B cell receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of cold-induced thermogenesis IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of cold-induced thermogenesis IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in phosphatidylinositol metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in phosphatidylinositol-mediated signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of synaptic transmission, GABAergic IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of synaptic transmission, GABAergic IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within regulation of synaptic transmission, GABAergic IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in release of sequestered calcium ion into cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
inactive phospholipase C-like protein 2
Names
PLC-L(2)
PLC-epsilon-2
phospholipase C, epsilon 2
phospholipase C-L2
NP_038908.2
XP_006524213.1
XP_006524214.1
XP_006524215.1
XP_036016445.1

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_013880.3 → NP_038908.2  inactive phospholipase C-like protein 2

    See identical proteins and their annotated locations for NP_038908.2

    Status: VALIDATED

    Source sequence(s)
    AB033615, AK134985, AK137821, BE983099, BY125070, CD553464
    Consensus CDS
    CCDS28875.1
    UniProtKB/Swiss-Prot
    Q3U4E2, Q80TK5, Q8K394, Q9QYG1
    Related
    ENSMUSP00000046584.7, ENSMUST00000043938.8
    Conserved Domains (4) summary
    cd00275
    Location:754 → 882
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd08597
    Location:426 → 722
    PI-PLCc_PRIP_metazoa; Catalytic domain of metazoan phospholipase C related, but catalytically inactive protein
    cd13364
    Location:144 → 252
    PH_PLC_eta; Phospholipase C-eta (PLC-eta) pleckstrin homology (PH) domain
    cd16223
    Location:272 → 415
    EFh_PRIP2; EF-hand motif found in phospholipase C-related but catalytically inactive protein 2 (PRIP-2)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    50815893..50995522
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006524151.4 → XP_006524214.1  inactive phospholipase C-like protein 2 isoform X1

    See identical proteins and their annotated locations for XP_006524214.1

    UniProtKB/Swiss-Prot
    Q3U4E2, Q80TK5, Q8K394, Q9QYG1
    Conserved Domains (4) summary
    cd00275
    Location:754 → 882
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd08597
    Location:426 → 722
    PI-PLCc_PRIP_metazoa; Catalytic domain of metazoan phospholipase C related, but catalytically inactive protein
    cd13364
    Location:144 → 252
    PH_PLC_eta; Phospholipase C-eta (PLC-eta) pleckstrin homology (PH) domain
    cd16223
    Location:272 → 415
    EFh_PRIP2; EF-hand motif found in phospholipase C-related but catalytically inactive protein 2 (PRIP-2)

  2. XM_036160552.1 → XP_036016445.1  inactive phospholipase C-like protein 2 isoform X2

    Conserved Domains (4) summary
    cd00275
    Location:754 → 882
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd08597
    Location:426 → 722
    PI-PLCc_PRIP_metazoa; Catalytic domain of metazoan phospholipase C related, but catalytically inactive protein
    cd13364
    Location:144 → 252
    PH_PLC_eta; Phospholipase C-eta (PLC-eta) pleckstrin homology (PH) domain
    cd16223
    Location:272 → 415
    EFh_PRIP2; EF-hand motif found in phospholipase C-related but catalytically inactive protein 2 (PRIP-2)

  3. XM_006524152.4 → XP_006524215.1  inactive phospholipase C-like protein 2 isoform X1

    See identical proteins and their annotated locations for XP_006524215.1

    UniProtKB/Swiss-Prot
    Q3U4E2, Q80TK5, Q8K394, Q9QYG1
    Conserved Domains (4) summary
    cd00275
    Location:754 → 882
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd08597
    Location:426 → 722
    PI-PLCc_PRIP_metazoa; Catalytic domain of metazoan phospholipase C related, but catalytically inactive protein
    cd13364
    Location:144 → 252
    PH_PLC_eta; Phospholipase C-eta (PLC-eta) pleckstrin homology (PH) domain
    cd16223
    Location:272 → 415
    EFh_PRIP2; EF-hand motif found in phospholipase C-related but catalytically inactive protein 2 (PRIP-2)

  4. XM_006524150.4 → XP_006524213.1  inactive phospholipase C-like protein 2 isoform X1

    See identical proteins and their annotated locations for XP_006524213.1

    UniProtKB/Swiss-Prot
    Q3U4E2, Q80TK5, Q8K394, Q9QYG1
    Conserved Domains (4) summary
    cd00275
    Location:754 → 882
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd08597
    Location:426 → 722
    PI-PLCc_PRIP_metazoa; Catalytic domain of metazoan phospholipase C related, but catalytically inactive protein
    cd13364
    Location:144 → 252
    PH_PLC_eta; Phospholipase C-eta (PLC-eta) pleckstrin homology (PH) domain
    cd16223
    Location:272 → 415
    EFh_PRIP2; EF-hand motif found in phospholipase C-related but catalytically inactive protein 2 (PRIP-2)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8K394.2 GenPept UniProtKB/Swiss-Prot:Q8K394

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