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Pex6 peroxisomal biogenesis factor 6 [ Mus musculus (house mouse) ]

Gene ID: 224824, updated on 8-Feb-2024

Summary

Official Symbol
Pex6provided by MGI
Official Full Name
peroxisomal biogenesis factor 6provided by MGI
Primary source
MGI:MGI:2385054
See related
Ensembl:ENSMUSG00000002763 AllianceGenome:MGI:2385054
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
PAF-2; D130055I09Rik
Summary
Predicted to enable ATP binding activity; ATP hydrolysis activity; and protein C-terminus binding activity. Predicted to be involved in protein import into peroxisome matrix, translocation and protein stabilization. Located in photoreceptor cell cilium. Is expressed in brain; embryo; liver; and metanephros. Human ortholog(s) of this gene implicated in Heimler syndrome 2; peroxisomal biogenesis disorder; and peroxisome biogenesis disorder 4A. Orthologous to human PEX6 (peroxisomal biogenesis factor 6). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in adrenal adult (RPKM 85.9), ovary adult (RPKM 56.9) and 28 other tissues See more
Orthologs
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Genomic context

See Pex6 in Genome Data Viewer
Location:
17 C; 17 22.9 cM
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (47022402..47036469)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (46711476..46725543)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_42676 Neighboring gene STARR-positive B cell enhancer mm9_chr17:46817738-46818039 Neighboring gene kelch domain containing 3 Neighboring gene male enhanced antigen 1 Neighboring gene protein phosphatase 2, regulatory subunit B', delta Neighboring gene STARR-positive B cell enhancer ABC_E7538 Neighboring gene glycine N-methyltransferase Neighboring gene canopy FGF signaling regulator 3 Neighboring gene STARR-positive B cell enhancer ABC_E2490 Neighboring gene STARR-positive B cell enhancer ABC_E3204

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC6455, KIAA4177

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding ISO
Inferred from Sequence Orthology
more info
 
enables ATP hydrolysis activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables ATP hydrolysis activity ISO
Inferred from Sequence Orthology
more info
 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein transporter activity ISO
Inferred from Sequence Orthology
more info
 
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
 
enables ubiquitin-dependent protein binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in peroxisome organization ISO
Inferred from Sequence Orthology
more info
 
involved_in protein import into peroxisome matrix IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in protein import into peroxisome matrix, receptor recycling ISO
Inferred from Sequence Orthology
more info
 
involved_in protein import into peroxisome matrix, translocation ISO
Inferred from Sequence Orthology
more info
 
involved_in protein stabilization ISO
Inferred from Sequence Orthology
more info
 
involved_in protein targeting to peroxisome ISO
Inferred from Sequence Orthology
more info
 
involved_in protein unfolding ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in cell projection IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in peroxisomal membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in peroxisomal membrane ISO
Inferred from Sequence Orthology
more info
 
located_in peroxisomal membrane ISO
Inferred from Sequence Orthology
more info
 
located_in peroxisome ISO
Inferred from Sequence Orthology
more info
 
located_in photoreceptor cell cilium IDA
Inferred from Direct Assay
more info
PubMed 
located_in photoreceptor cell cilium ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
peroxisomal ATPase PEX6
Names
peroxin-6
peroxisomal-type ATPase 1
peroxisome assembly factor 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_145488.2NP_663463.1  peroxisomal ATPase PEX6

    See identical proteins and their annotated locations for NP_663463.1

    Status: VALIDATED

    Source sequence(s)
    CT030702
    Consensus CDS
    CCDS28837.1
    UniProtKB/Swiss-Prot
    Q6YNQ9, Q99LC9
    UniProtKB/TrEMBL
    Q5DTJ5
    Related
    ENSMUSP00000002840.9, ENSMUST00000002840.9
    Conserved Domains (2) summary
    COG0464
    Location:464968
    SpoVK; AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms]
    pfam00004
    Location:744872
    AAA; ATPase family associated with various cellular activities (AAA)

RNA

  1. NR_157369.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AK143173, AK220525, CT030702
    Related
    ENSMUST00000144964.8

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    47022402..47036469
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)