Clic5 chloride intracellular channel 5 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Clic5provided by MGI
Official Full Name: chloride intracellular channel 5provided by MGI
Primary source: MGI:MGI:1917912
See related: Ensembl:ENSMUSG00000023959 AllianceGenome:MGI:1917912
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: jbg; Gm322; nmf318; B330005L24; 5730531E12Rik
Summary: Predicted to enable chloride channel activity. Involved in inner ear receptor cell stereocilium organization and protein localization. Acts upstream of or within several processes, including auditory receptor cell stereocilium organization; diet induced thermogenesis; and sensory perception of sound. Located in stereocilium base. Is expressed in several structures, including gut; inner ear; lung; male reproductive gland or organ; and metanephros. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 103. Orthologous to human CLIC5 (chloride intracellular channel 5). [provided by Alliance of Genome Resources, Jan 2025]
Expression: Biased expression in lung adult (RPKM 40.1), large intestine adult (RPKM 14.4) and 10 other tissues See more
Orthologs: human all
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Genomic context

Location:: 17 B3; 17 20.53 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	17	NC_000083.7 (44445671..44591059)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	17	NC_000083.6 (44134762..44280169)

Chromosome 17 - NC_000083.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

These results suggest that KLPH is required for lens-specific expression of Clic5 and that Clic5 has an important role in the machinery that controls lens fiber cell extension and organization.
Title: The klotho-related protein KLPH (lctl) has preferred expression in lens and is essential for expression of clic5 and normal lens suture formation.
Results indicate CLICs-dependent chloride efflux as an essential and proximal upstream event for NLRP3 activation.
Title: CLICs-dependent chloride efflux is an essential and proximal upstream event for NLRP3 inflammasome activation.
The findings indicate that CLIC4/CLIC5A-mediated ERM activation is required for maintenance of the glomerular capillary architecture.
Title: Both CLIC4 and CLIC5A activate ERM proteins in glomerular endothelium.
Augmented hypertension-induced glomerular capillary injury in mice lacking CLIC5 results from abrogation of Rac1-dependent Pak and ezrin activation, perhaps reducing the tensile strength of the podocyte actin cytoskeleton.
Title: The chloride intracellular channel 5A stimulates podocyte Rac1, protecting against hypertension-induced glomerular injury.
The mechanism of CLIC5A action involves clustered plasma membrane phosphatidylinositol 4,5-bisphosphate accumulation, in turn facilitating ezrin activation and actin-dependent cell surface remodeling.
Title: Clustered PI(4,5)P₂ accumulation and ezrin phosphorylation in response to CLIC5A.
Biochemical assays showed interaction of CLIC5 with ERM proteins, TPRN, and possibly myosin VI (MYO6). In addition, CLIC5 and RDX failed to localize normally in fused stereocilia of MYO6 mutant mice
Title: CLIC5 stabilizes membrane-actin filament linkages at the base of hair cell stereocilia in a molecular complex with radixin, taperin, and myosin VI.
miR-96 and miR-182 regulate the in vivo expression of CLIC5 in mouse inner ear hair cells
Title: MiR-183 family regulates chloride intracellular channel 5 expression in inner ear hair cells.
Study identifies CLIC5 as a new component that is enriched in and necessary for foot process integrity and podocyte function in vivo.
Title: Proteomic analysis of the slit diaphragm complex: CLIC5 is a protein critical for podocyte morphology and function.
CLIC5 disrupts proliferation of C2C12 cells and is involved in the differentiation of myoblasts by enhancing the protein expression level of MyHC, myogenin and desmin.
Title: The CLIC5 (chloride intracellular channel 5) involved in C2C12 myoblasts proliferation and differentiation.
Clic5 mutant mice are resistant to diet-induced obesity.
Title: CLIC5 mutant mice are resistant to diet-induced obesity and exhibit gastric hemorrhaging and increased susceptibility to torpor.

Submit: New GeneRIF Correction See all GeneRIFs (12)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Chemically induced (ENU) (1)
Endonuclease-mediated (4)
Spontaneous (2) 1 citation
Targeted (2)

General gene information

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Markers

Clic5 (e-PCR), detects polymorphism
- UniSTS:507957

Clic5 (e-PCR), detects polymorphism
- UniSTS:507958

Clic5 (e-PCR), detects polymorphism
- UniSTS:507959

Clic5 (e-PCR), detects polymorphism
- UniSTS:507960

Clic5 (e-PCR), detects polymorphism
- UniSTS:507961

NoName (e-PCR)
- UniSTS:237651

D17Mit136 (e-PCR), detects polymorphism
- UniSTS:127964

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables chloride channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables chloride channel activity	IEA Inferred from Electronic Annotation more info
enables chloride channel activity	ISO Inferred from Sequence Orthology more info
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within auditory receptor cell stereocilium organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in chloride transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in chloride transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in chloride transport	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within diet induced thermogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in inner ear receptor cell stereocilium organization	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within neuromuscular process controlling balance	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within protein localization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein localization	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to dietary excess	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within sensory perception of sound	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sensory perception of sound	ISO Inferred from Sequence Orthology more info
involved_in sensory perception of sound	ISS Inferred from Sequence or Structural Similarity more info
involved_in visual perception	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	IEA Inferred from Electronic Annotation more info
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
located_in actin cytoskeleton	ISO Inferred from Sequence Orthology more info
located_in actin cytoskeleton	ISS Inferred from Sequence or Structural Similarity more info
located_in apical plasma membrane	IEA Inferred from Electronic Annotation more info
located_in apical plasma membrane	ISO Inferred from Sequence Orthology more info
located_in cell cortex	IEA Inferred from Electronic Annotation more info
located_in centrosome	IEA Inferred from Electronic Annotation more info
part_of chloride channel complex	IEA Inferred from Electronic Annotation more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	TAS Traceable Author Statement more info
located_in stereocilium	IDA Inferred from Direct Assay more info	PubMed
located_in stereocilium base	IDA Inferred from Direct Assay more info	PubMed
located_in stereocilium base	ISO Inferred from Sequence Orthology more info
located_in stereocilium bundle	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: chloride intracellular channel protein 5

Names: glutaredoxin-like oxidoreductase CLIC5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_172621.2 → NP_766209.1 chloride intracellular channel protein 5

Status: VALIDATED

Source sequence(s)

AC116688, AC153418, AK156849

Consensus CDS

CCDS28804.1

UniProtKB/Swiss-Prot

Q3U0H8, Q8BXK9

Related

ENSMUSP00000024755.6, ENSMUST00000024755.7

Conserved Domains (1) summary

TIGR00862
Location:14 → 249

O-ClC; intracellular chloride channel protein

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000083.7 Reference GRCm39 C57BL/6J

Range

44445671..44591059

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006524135.5 → XP_006524198.1 chloride intracellular channel protein 5 isoform X1

UniProtKB/TrEMBL

A0A668KLB7

Related

ENSMUSP00000159274.2, ENSMUST00000239215.2

Conserved Domains (1) summary

TIGR00862
Location:248 → 483

O-ClC; intracellular chloride channel protein