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Anks1 ankyrin repeat and SAM domain containing 1 [ Mus musculus (house mouse) ]

Gene ID: 224650, updated on 21-Apr-2024

Summary

Official Symbol
Anks1provided by MGI
Official Full Name
ankyrin repeat and SAM domain containing 1provided by MGI
Primary source
MGI:MGI:2446180
See related
Ensembl:ENSMUSG00000024219 AllianceGenome:MGI:2446180
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Anks1a; mKIAA0229
Summary
Enables ephrin receptor binding activity. Involved in ephrin receptor signaling pathway; neuron remodeling; and substrate-dependent cell migration. Acts upstream of or within negative regulation of ubiquitin-dependent protein catabolic process and regulation of ephrin receptor signaling pathway. Located in neuron projection. Is expressed in several structures, including genitourinary system; gut gland; nervous system; olfactory epithelium; and trachea. Orthologous to human ANKS1A (ankyrin repeat and sterile alpha motif domain containing 1A). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in lung adult (RPKM 18.8), thymus adult (RPKM 17.2) and 28 other tissues See more
Orthologs
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Genomic context

Location:
17 A3.3; 17 14.6 cM
Exon count:
31
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (28128273..28281753)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (27909304..28062779)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:27976840-27977098 Neighboring gene U1 small nuclear ribonucleoprotein C Neighboring gene bridge-like lipid transfer protein family member 3A Neighboring gene STARR-positive B cell enhancer ABC_E7504 Neighboring gene TATA-box binding protein associated factor 11 Neighboring gene STARR-seq mESC enhancer starr_42177 Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:28144121-28144327 Neighboring gene predicted gene, 35290 Neighboring gene tRNA splicing endonuclease 34 pseudogene Neighboring gene STARR-seq mESC enhancer starr_42185 Neighboring gene STARR-positive B cell enhancer ABC_E4199 Neighboring gene t-complex protein 11 Neighboring gene VISTA enhancer mm1525 Neighboring gene signal peptide, CUB domain, EGF-like 3

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (2) 
  • Targeted (3)  1 citation
  • Endonuclease-mediated (1) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC59413

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ephrin receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables ephrin receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in neuron projection IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
ankyrin repeat and SAM domain-containing protein 1A
Names
Odin

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001286040.1NP_001272969.1  ankyrin repeat and SAM domain-containing protein 1A isoform 1

    See identical proteins and their annotated locations for NP_001272969.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC126040, AC132460, AK147273
    Consensus CDS
    CCDS70777.1
    UniProtKB/TrEMBL
    Q3UHP6
    Related
    ENSMUSP00000025058.8, ENSMUST00000025058.15
    Conserved Domains (7) summary
    cd09499
    Location:713779
    SAM_AIDA1AB-like_repeat1; SAM domain of AIDA1AB-like proteins, repeat 1
    cd09500
    Location:784848
    SAM_AIDA1AB-like_repeat2; SAM domain of AIDA1AB-like proteins, repeat 2
    smart00454
    Location:716775
    SAM; Sterile alpha motif
    cd00204
    Location:70219
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd01274
    Location:9421087
    PTB_Anks; Ankyrin repeat and sterile alpha motif (SAM) domain-containing (Anks) protein family Phosphotyrosine-binding (PTB) domain
    pfam12796
    Location:203294
    Ank_2; Ankyrin repeats (3 copies)
    sd00045
    Location:165196
    ANK; ANK repeat [structural motif]
  2. NM_001286041.1NP_001272970.1  ankyrin repeat and SAM domain-containing protein 1A isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an in-frame exon the 5' coding region compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AC126040, AC132460
    Consensus CDS
    CCDS70778.1
    UniProtKB/Swiss-Prot
    P59672
    Related
    ENSMUSP00000085344.6, ENSMUST00000088027.7
    Conserved Domains (7) summary
    cd09499
    Location:692758
    SAM_AIDA1AB-like_repeat1; SAM domain of AIDA1AB-like proteins, repeat 1
    cd09500
    Location:763827
    SAM_AIDA1AB-like_repeat2; SAM domain of AIDA1AB-like proteins, repeat 2
    smart00454
    Location:695754
    SAM; Sterile alpha motif
    cd00204
    Location:70198
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd01274
    Location:9211066
    PTB_Anks; Ankyrin repeat and sterile alpha motif (SAM) domain-containing (Anks) protein family Phosphotyrosine-binding (PTB) domain
    pfam12796
    Location:80175
    Ank_2; Ankyrin repeats (3 copies)
    sd00045
    Location:76106
    ANK; ANK repeat [structural motif]
  3. NM_001374802.1NP_001361731.1  ankyrin repeat and SAM domain-containing protein 1A isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC126040, AC132460
    Consensus CDS
    CCDS89037.1
    UniProtKB/TrEMBL
    A0A3B2WAQ7
    Related
    ENSMUSP00000156466.2, ENSMUST00000233525.2
    Conserved Domains (5) summary
    cd09499
    Location:692758
    SAM_AIDA1AB-like_repeat1; SAM domain of AIDA1AB-like proteins, repeat 1
    cd09500
    Location:763827
    SAM_AIDA1AB-like_repeat2; SAM domain of AIDA1AB-like proteins, repeat 2
    PHA03095
    Location:66280
    PHA03095; ankyrin-like protein; Provisional
    cd01274
    Location:9211066
    PTB_Anks; Ankyrin repeat and sterile alpha motif (SAM) domain-containing (Anks) protein family Phosphotyrosine-binding (PTB) domain
    sd00045
    Location:76106
    ANK; ANK repeat [structural motif]
  4. NM_001425247.1NP_001412176.1  ankyrin repeat and SAM domain-containing protein 1A isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC126040, AC132460
  5. NM_181413.4NP_852078.1  ankyrin repeat and SAM domain-containing protein 1A isoform 3

    See identical proteins and their annotated locations for NP_852078.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) use an alternate structure at the 3' end which results in a frameshift compared to variant 1. The encoded isoform (3) is shorter and has a distinct C-terminus compared to isoform 2.
    Source sequence(s)
    AC126040, AC132460
    Consensus CDS
    CCDS37525.1
    UniProtKB/Swiss-Prot
    P59672, Q6ZQG0
    Related
    ENSMUSP00000110491.2, ENSMUST00000114842.9
    Conserved Domains (7) summary
    cd09499
    Location:713779
    SAM_AIDA1AB-like_repeat1; SAM domain of AIDA1AB-like proteins, repeat 1
    cd09500
    Location:784848
    SAM_AIDA1AB-like_repeat2; SAM domain of AIDA1AB-like proteins, repeat 2
    smart00454
    Location:716775
    SAM; Sterile alpha motif
    cd00204
    Location:70219
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd01274
    Location:9421087
    PTB_Anks; Ankyrin repeat and sterile alpha motif (SAM) domain-containing (Anks) protein family Phosphotyrosine-binding (PTB) domain
    pfam12796
    Location:203294
    Ank_2; Ankyrin repeats (3 copies)
    sd00045
    Location:165196
    ANK; ANK repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    28128273..28281753
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006524087.3XP_006524150.1  ankyrin repeat and SAM domain-containing protein 1A isoform X1

    See identical proteins and their annotated locations for XP_006524150.1

    Conserved Domains (6) summary
    cd09499
    Location:713779
    SAM_AIDA1AB-like_repeat1; SAM domain of AIDA1AB-like proteins, repeat 1
    cd09500
    Location:784848
    SAM_AIDA1AB-like_repeat2; SAM domain of AIDA1AB-like proteins, repeat 2
    PHA03095
    Location:66301
    PHA03095; ankyrin-like protein; Provisional
    cd01274
    Location:9421087
    PTB_Anks; Ankyrin repeat and sterile alpha motif (SAM) domain-containing (Anks) protein family Phosphotyrosine-binding (PTB) domain
    sd00045
    Location:165196
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:203294
    Ank_2; Ankyrin repeats (3 copies)
  2. XM_006524088.3XP_006524151.1  ankyrin repeat and SAM domain-containing protein 1A isoform X2

    See identical proteins and their annotated locations for XP_006524151.1

    Conserved Domains (6) summary
    cd09499
    Location:713779
    SAM_AIDA1AB-like_repeat1; SAM domain of AIDA1AB-like proteins, repeat 1
    cd09500
    Location:784848
    SAM_AIDA1AB-like_repeat2; SAM domain of AIDA1AB-like proteins, repeat 2
    PHA03095
    Location:66301
    PHA03095; ankyrin-like protein; Provisional
    cd01274
    Location:9421087
    PTB_Anks; Ankyrin repeat and sterile alpha motif (SAM) domain-containing (Anks) protein family Phosphotyrosine-binding (PTB) domain
    sd00045
    Location:165196
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:203294
    Ank_2; Ankyrin repeats (3 copies)
  3. XM_030249683.2XP_030105543.1  ankyrin repeat and SAM domain-containing protein 1A isoform X3

    Conserved Domains (6) summary
    cd09499
    Location:674740
    SAM_AIDA1AB-like_repeat1; SAM domain of AIDA1AB-like proteins, repeat 1
    cd09500
    Location:745809
    SAM_AIDA1AB-like_repeat2; SAM domain of AIDA1AB-like proteins, repeat 2
    PHA03095
    Location:27262
    PHA03095; ankyrin-like protein; Provisional
    cd01274
    Location:9031048
    PTB_Anks; Ankyrin repeat and sterile alpha motif (SAM) domain-containing (Anks) protein family Phosphotyrosine-binding (PTB) domain
    sd00045
    Location:126157
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:164255
    Ank_2; Ankyrin repeats (3 copies)
  4. XM_030249682.1XP_030105542.1  ankyrin repeat and SAM domain-containing protein 1A isoform X3

    Conserved Domains (6) summary
    cd09499
    Location:674740
    SAM_AIDA1AB-like_repeat1; SAM domain of AIDA1AB-like proteins, repeat 1
    cd09500
    Location:745809
    SAM_AIDA1AB-like_repeat2; SAM domain of AIDA1AB-like proteins, repeat 2
    PHA03095
    Location:27262
    PHA03095; ankyrin-like protein; Provisional
    cd01274
    Location:9031048
    PTB_Anks; Ankyrin repeat and sterile alpha motif (SAM) domain-containing (Anks) protein family Phosphotyrosine-binding (PTB) domain
    sd00045
    Location:126157
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:164255
    Ank_2; Ankyrin repeats (3 copies)
  5. XM_030249685.1XP_030105545.1  ankyrin repeat and SAM domain-containing protein 1A isoform X5

    Conserved Domains (6) summary
    cd09499
    Location:651717
    SAM_AIDA1AB-like_repeat1; SAM domain of AIDA1AB-like proteins, repeat 1
    cd09500
    Location:722786
    SAM_AIDA1AB-like_repeat2; SAM domain of AIDA1AB-like proteins, repeat 2
    PHA03095
    Location:4239
    PHA03095; ankyrin-like protein; Provisional
    cd01274
    Location:8801025
    PTB_Anks; Ankyrin repeat and sterile alpha motif (SAM) domain-containing (Anks) protein family Phosphotyrosine-binding (PTB) domain
    sd00045
    Location:103134
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:141232
    Ank_2; Ankyrin repeats (3 copies)
  6. XM_006524089.5XP_006524152.1  ankyrin repeat and SAM domain-containing protein 1A isoform X3

    See identical proteins and their annotated locations for XP_006524152.1

    Conserved Domains (6) summary
    cd09499
    Location:674740
    SAM_AIDA1AB-like_repeat1; SAM domain of AIDA1AB-like proteins, repeat 1
    cd09500
    Location:745809
    SAM_AIDA1AB-like_repeat2; SAM domain of AIDA1AB-like proteins, repeat 2
    PHA03095
    Location:27262
    PHA03095; ankyrin-like protein; Provisional
    cd01274
    Location:9031048
    PTB_Anks; Ankyrin repeat and sterile alpha motif (SAM) domain-containing (Anks) protein family Phosphotyrosine-binding (PTB) domain
    sd00045
    Location:126157
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:164255
    Ank_2; Ankyrin repeats (3 copies)
  7. XM_030249686.2XP_030105546.1  ankyrin repeat and SAM domain-containing protein 1A isoform X8

    UniProtKB/TrEMBL
    A0A3B2W7H4, Q3TE53
    Conserved Domains (3) summary
    cd09499
    Location:156222
    SAM_AIDA1AB-like_repeat1; SAM domain of AIDA1AB-like proteins, repeat 1
    cd09500
    Location:227291
    SAM_AIDA1AB-like_repeat2; SAM domain of AIDA1AB-like proteins, repeat 2
    cd01274
    Location:385530
    PTB_Anks; Ankyrin repeat and sterile alpha motif (SAM) domain-containing (Anks) protein family Phosphotyrosine-binding (PTB) domain
  8. XM_036160515.1XP_036016408.1  ankyrin repeat and SAM domain-containing protein 1A isoform X6

    Conserved Domains (3) summary
    cd09499
    Location:156222
    SAM_AIDA1AB-like_repeat1; SAM domain of AIDA1AB-like proteins, repeat 1
    cd09500
    Location:227291
    SAM_AIDA1AB-like_repeat2; SAM domain of AIDA1AB-like proteins, repeat 2
    cd01274
    Location:385530
    PTB_Anks; Ankyrin repeat and sterile alpha motif (SAM) domain-containing (Anks) protein family Phosphotyrosine-binding (PTB) domain
  9. XM_036160516.1XP_036016409.1  ankyrin repeat and SAM domain-containing protein 1A isoform X7

    UniProtKB/TrEMBL
    Q3TE53
    Conserved Domains (3) summary
    cd09499
    Location:156222
    SAM_AIDA1AB-like_repeat1; SAM domain of AIDA1AB-like proteins, repeat 1
    cd09500
    Location:227291
    SAM_AIDA1AB-like_repeat2; SAM domain of AIDA1AB-like proteins, repeat 2
    cd01274
    Location:385530
    PTB_Anks; Ankyrin repeat and sterile alpha motif (SAM) domain-containing (Anks) protein family Phosphotyrosine-binding (PTB) domain
  10. XM_006524091.4XP_006524154.1  ankyrin repeat and SAM domain-containing protein 1A isoform X8

    See identical proteins and their annotated locations for XP_006524154.1

    UniProtKB/TrEMBL
    A0A3B2W7H4, Q3TE53
    Related
    ENSMUSP00000156518.2, ENSMUST00000139173.3
    Conserved Domains (3) summary
    cd09499
    Location:156222
    SAM_AIDA1AB-like_repeat1; SAM domain of AIDA1AB-like proteins, repeat 1
    cd09500
    Location:227291
    SAM_AIDA1AB-like_repeat2; SAM domain of AIDA1AB-like proteins, repeat 2
    cd01274
    Location:385530
    PTB_Anks; Ankyrin repeat and sterile alpha motif (SAM) domain-containing (Anks) protein family Phosphotyrosine-binding (PTB) domain
  11. XM_036160517.1XP_036016410.1  ankyrin repeat and SAM domain-containing protein 1A isoform X7

    UniProtKB/TrEMBL
    Q3TE53
    Conserved Domains (3) summary
    cd09499
    Location:156222
    SAM_AIDA1AB-like_repeat1; SAM domain of AIDA1AB-like proteins, repeat 1
    cd09500
    Location:227291
    SAM_AIDA1AB-like_repeat2; SAM domain of AIDA1AB-like proteins, repeat 2
    cd01274
    Location:385530
    PTB_Anks; Ankyrin repeat and sterile alpha motif (SAM) domain-containing (Anks) protein family Phosphotyrosine-binding (PTB) domain
  12. XM_030249687.2XP_030105547.1  ankyrin repeat and SAM domain-containing protein 1A isoform X10

    UniProtKB/TrEMBL
    A0A3B2W4H6
    Conserved Domains (3) summary
    cd09500
    Location:36100
    SAM_AIDA1AB-like_repeat2; SAM domain of AIDA1AB-like proteins, repeat 2
    cd01274
    Location:194339
    PTB_Anks; Ankyrin repeat and sterile alpha motif (SAM) domain-containing (Anks) protein family Phosphotyrosine-binding (PTB) domain
    cl15755
    Location:131
    SAM_superfamily; SAM (Sterile alpha motif )
  13. XM_036160518.1XP_036016411.1  ankyrin repeat and SAM domain-containing protein 1A isoform X9

    UniProtKB/TrEMBL
    A0A3B2W4H6
    Related
    ENSMUSP00000156946.2, ENSMUST00000232872.2
    Conserved Domains (3) summary
    cd09499
    Location:1783
    SAM_AIDA1AB-like_repeat1; SAM domain of AIDA1AB-like proteins, repeat 1
    cd09500
    Location:88152
    SAM_AIDA1AB-like_repeat2; SAM domain of AIDA1AB-like proteins, repeat 2
    cd01274
    Location:246391
    PTB_Anks; Ankyrin repeat and sterile alpha motif (SAM) domain-containing (Anks) protein family Phosphotyrosine-binding (PTB) domain