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Ilrun inflammation and lipid regulator with UBA-like and NBR1-like domains [ Mus musculus (house mouse) ]

Gene ID: 224647, updated on 9-May-2024

Summary

Official Symbol
Ilrunprovided by MGI
Official Full Name
inflammation and lipid regulator with UBA-like and NBR1-like domainsprovided by MGI
Primary source
MGI:MGI:106281
See related
Ensembl:ENSMUSG00000056692 AllianceGenome:MGI:106281
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
D17Wsu92e; C030010A15
Summary
Predicted to enable ubiquitin binding activity. Predicted to be involved in several processes, including negative regulation of cytokine production; negative regulation of defense response to virus; and negative regulation of protein localization to nucleus. Predicted to act upstream of or within innate immune response. Predicted to be located in centrosome; cytosol; and nuclear speck. Predicted to be active in phagophore assembly site. Is expressed in several structures, including alimentary system; eye; genitourinary system; integumental system; and nervous system. Orthologous to human ILRUN (inflammation and lipid regulator with UBA-like and NBR1-like domains). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in kidney adult (RPKM 61.3), liver adult (RPKM 60.3) and 28 other tissues See more
Orthologs
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Genomic context

See Ilrun in Genome Data Viewer
Location:
17 A3.3; 17 14.59 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (27970206..28039516, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (27751232..27820542, complement)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene protein kinase C and casein kinase substrate in neurons 1 Neighboring gene STARR-seq mESC enhancer starr_42171 Neighboring gene SAM pointed domain containing ets transcription factor Neighboring gene ribosomal protein S2, pseudogene 9 Neighboring gene STARR-seq mESC enhancer starr_42174 Neighboring gene STARR-positive B cell enhancer ABC_E2475 Neighboring gene STARR-positive B cell enhancer ABC_E4198 Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:27976840-27977098 Neighboring gene U1 small nuclear ribonucleoprotein C Neighboring gene bridge-like lipid transfer protein family member 3A

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Gene trapped (1) 
  • Targeted (1) 

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ubiquitin binding IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
located_in centrosome ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in nuclear speck ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
is_active_in phagophore assembly site IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
protein ILRUN
Names
uncharacterized protein C6orf106 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001033279.3NP_001028451.2  protein ILRUN isoform 1

    See identical proteins and their annotated locations for NP_001028451.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC131799, AK161603
    Consensus CDS
    CCDS28569.1
    UniProtKB/Swiss-Prot
    A2RT11, Q3TT38
    UniProtKB/TrEMBL
    B2KF52
    Related
    ENSMUSP00000110513.3, ENSMUST00000114863.10
    Conserved Domains (2) summary
    cd14349
    Location:2364
    UBA_CF106; UBA-like domain found in uncharacterized protein C6orf106 and similar proteins
    cd14947
    Location:71180
    NBR1_like; Functionally uncharacterized domain in neighbor of Brca1 Gene 1 and related proteins
  2. NM_001044719.2NP_001038184.1  protein ILRUN isoform 2

    See identical proteins and their annotated locations for NP_001038184.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AC131799, BC137573
    Consensus CDS
    CCDS37523.1
    UniProtKB/TrEMBL
    A0A3B2W3W9, B2KF54
    Related
    ENSMUSP00000110509.2, ENSMUST00000114859.9
    Conserved Domains (2) summary
    cd14349
    Location:2364
    UBA_CF106; UBA-like domain found in uncharacterized protein C6orf106 and similar proteins
    cd14947
    Location:71180
    NBR1_like; Functionally uncharacterized domain in neighbor of Brca1 Gene 1 and related proteins
  3. NM_001271511.1NP_001258440.1  protein ILRUN isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an alternate exon, which results in a frameshift, compared to variant 1. The encoded isoform (3) is shorter and has a distinct C-terminus, compared to variant 1.
    Source sequence(s)
    AC131799, AK161603, BY755073
    Consensus CDS
    CCDS89036.1
    UniProtKB/TrEMBL
    A0A3B2WCT9
    Related
    ENSMUSP00000156684.2, ENSMUST00000233508.2
    Conserved Domains (2) summary
    cd14349
    Location:2364
    UBA_CF106; UBA-like domain found in uncharacterized protein C6orf106 and similar proteins
    cd14947
    Location:71170
    NBR1_like; Functionally uncharacterized domain in neighbor of Brca1 Gene 1 and related proteins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    27970206..28039516 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)