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Rab40c Rab40C, member RAS oncogene family [ Mus musculus (house mouse) ]

Gene ID: 224624, updated on 30-Apr-2024

Summary

Official Symbol
Rab40cprovided by MGI
Official Full Name
Rab40C, member RAS oncogene familyprovided by MGI
Primary source
MGI:MGI:2183454
See related
Ensembl:ENSMUSG00000025730 AllianceGenome:MGI:2183454
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
RAR3
Summary
Predicted to enable GDP binding activity and GTP binding activity. Predicted to be involved in protein localization to plasma membrane. Predicted to be located in perinuclear region of cytoplasm. Predicted to be active in endosome; plasma membrane; and synaptic vesicle. Is expressed in several structures, including alimentary system; brain; cardiovascular system; genitourinary system; and hemolymphoid system gland. Orthologous to human RAB40C (RAB40C, member RAS oncogene family). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in adrenal adult (RPKM 24.2), ovary adult (RPKM 23.3) and 28 other tissues See more
Orthologs
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Genomic context

See Rab40c in Genome Data Viewer
Location:
17 A3.3; 17 12.97 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (26101088..26138688, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (25882114..25919714, complement)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene methyltransferase like 26 Neighboring gene WAP, FS, Ig, KU, and NTR-containing protein 1 Neighboring gene cytochrome c oxidase subunit 7C, pseudogene 1 Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:26056925-26057108 Neighboring gene phosphatidylinositol glycan anchor biosynthesis, class Q Neighboring gene NHL repeat containing 4 Neighboring gene RIKEN cDNA gene D630044L22 gene Neighboring gene proline rich 35

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables GDP binding ISO
Inferred from Sequence Orthology
more info
 
enables GTP binding ISO
Inferred from Sequence Orthology
more info
 
enables GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in exocytosis IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
 
involved_in protein secretion IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
colocalizes_with Golgi apparatus ISO
Inferred from Sequence Orthology
more info
 
is_active_in endosome IBA
Inferred from Biological aspect of Ancestor
more info
 
colocalizes_with lipid droplet ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in synaptic vesicle IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
ras-related protein Rab-40C
Names
RAR (RAS like GTPASE) like
SOCS box containing protein RAR3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_139154.2NP_631893.1  ras-related protein Rab-40C

    See identical proteins and their annotated locations for NP_631893.1

    Status: VALIDATED

    Source sequence(s)
    AC159277
    Consensus CDS
    CCDS28537.1
    UniProtKB/Swiss-Prot
    Q8VHQ4
    UniProtKB/TrEMBL
    E9PXR4, Q0PD11
    Related
    ENSMUSP00000026826.8, ENSMUST00000026826.14
    Conserved Domains (2) summary
    cd04121
    Location:9281
    Rab40; Rab GTPase family 40 (Rab40) contains Rab40a, Rab40b and Rab40c
    cd03742
    Location:187229
    SOCS_Rab40; SOCS (suppressors of cytokine signaling) box of Rab40-like proteins. Rab40 is part of the Rab family of small GTP-binding proteins that form the largest family within the Ras superfamily. Rab proteins regulate vesicular trafficking pathways, behaving as ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    26101088..26138688 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)