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Xdh xanthine dehydrogenase [ Mus musculus (house mouse) ]

Gene ID: 22436, updated on 31-Jan-2019

Summary

Official Symbol
Xdhprovided by MGI
Official Full Name
xanthine dehydrogenaseprovided by MGI
Primary source
MGI:MGI:98973
See related
Ensembl:ENSMUSG00000024066
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
XO; Xor; Xox1; Xox-1
Summary
This gene encodes a member of the xanthine dehydrogenase protein family. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. The encoded protein exists as two distinct enzymatic forms, either as xanthine dehydrogenase, or as xanthine oxidase, and functions in purine degradation. Additional studies also suggest a role in adipogenesis, and a function as a structural protein in milk fat droplets in the lactating mammary gland. [provided by RefSeq, Jan 2014]
Expression
Broad expression in duodenum adult (RPKM 55.7), small intestine adult (RPKM 47.7) and 16 other tissues See more
Orthologs

Genomic context

See Xdh in Genome Data Viewer
Location:
17 E2; 17 45.25 cM
Exon count:
36
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 17 NC_000083.6 (73883895..73950196, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 17 NC_000083.5 (74233248..74299522, complement)

Chromosome 17 - NC_000083.6Genomic Context describing neighboring genes Neighboring gene EH-domain containing 3 Neighboring gene trans-2,3-enoyl-CoA reductase pseudogene Neighboring gene predicted gene, 18068 Neighboring gene predicted gene, 30983 Neighboring gene steroid 5 alpha-reductase 2

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (3)  1 citation
  • Chemically induced (ENU) (1) 

Pathways from BioSystems

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
2 iron, 2 sulfur cluster binding ISO
Inferred from Sequence Orthology
more info
 
FAD binding IEA
Inferred from Electronic Annotation
more info
 
electron transfer activity IEA
Inferred from Electronic Annotation
more info
 
flavin adenine dinucleotide binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
flavin adenine dinucleotide binding ISO
Inferred from Sequence Orthology
more info
 
iron ion binding IEA
Inferred from Electronic Annotation
more info
 
iron-sulfur cluster binding IEA
Inferred from Electronic Annotation
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
molybdenum ion binding IEA
Inferred from Electronic Annotation
more info
 
molybdopterin cofactor binding ISO
Inferred from Sequence Orthology
more info
 
nitrite reductase (NO-forming) activity ISO
Inferred from Sequence Orthology
more info
 
oxidoreductase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
xanthine dehydrogenase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
xanthine dehydrogenase activity IDA
Inferred from Direct Assay
more info
PubMed 
xanthine dehydrogenase activity ISO
Inferred from Sequence Orthology
more info
 
xanthine oxidase activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
activation of cysteine-type endopeptidase activity involved in apoptotic process ISO
Inferred from Sequence Orthology
more info
 
hypoxanthine oxidation ISO
Inferred from Sequence Orthology
more info
 
lactation IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of endothelial cell differentiation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of endothelial cell proliferation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
negative regulation of protein kinase B signaling ISO
Inferred from Sequence Orthology
more info
 
negative regulation of protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of vascular endothelial growth factor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
negative regulation of vasculogenesis ISO
Inferred from Sequence Orthology
more info
 
oxidation-reduction process IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of p38MAPK cascade ISO
Inferred from Sequence Orthology
more info
 
positive regulation of reactive oxygen species metabolic process ISO
Inferred from Sequence Orthology
more info
 
regulation of epithelial cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
response to aluminum ion ISO
Inferred from Sequence Orthology
more info
 
xanthine catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
xanthine catabolic process ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol ISO
Inferred from Sequence Orthology
more info
 
extracellular region IEA
Inferred from Electronic Annotation
more info
 
extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
extracellular space ISO
Inferred from Sequence Orthology
more info
 
peroxisome IEA
Inferred from Electronic Annotation
more info
 
sarcoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
xanthine dehydrogenase/oxidase
Names
xanthine oxidase
xanthine oxidoreductase
NP_035853.2
XP_011244683.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_011723.3NP_035853.2  xanthine dehydrogenase/oxidase

    See identical proteins and their annotated locations for NP_035853.2

    Status: REVIEWED

    Source sequence(s)
    AI323529, AK008517, AK034256, AK143412, AK161529, BY318674
    Consensus CDS
    CCDS28967.1
    UniProtKB/Swiss-Prot
    Q00519
    UniProtKB/TrEMBL
    Q9CVF2
    Related
    ENSMUSP00000024866.4, ENSMUST00000024866.5
    Conserved Domains (6) summary
    PLN02906
    Location:261321
    PLN02906; xanthine dehydrogenase
    pfam00941
    Location:234414
    FAD_binding_5; FAD binding domain in molybdopterin dehydrogenase
    pfam01315
    Location:590696
    Ald_Xan_dh_C; Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain
    pfam01799
    Location:90160
    Fer2_2; [2Fe-2S] binding domain
    pfam02738
    Location:7141239
    Ald_Xan_dh_C2; Molybdopterin-binding domain of aldehyde dehydrogenase
    pfam03450
    Location:421525
    CO_deh_flav_C; CO dehydrogenase flavoprotein C-terminal domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000083.6 Reference GRCm38.p4 C57BL/6J

    Range
    73883895..73950196 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011246381.1XP_011244683.1  xanthine dehydrogenase/oxidase isoform X1

    Conserved Domains (3) summary
    COG4631
    Location:18776
    XdhB; Xanthine dehydrogenase, molybdopterin-binding subunit XdhB [Nucleotide transport and metabolism]
    pfam01315
    Location:54160
    Ald_Xan_dh_C; Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain
    pfam02738
    Location:178703
    Ald_Xan_dh_C2; Molybdopterin-binding domain of aldehyde dehydrogenase
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