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Wnt6 wingless-type MMTV integration site family, member 6 [ Mus musculus (house mouse) ]

Gene ID: 22420, updated on 8-Feb-2024

Summary

Official Symbol
Wnt6provided by MGI
Official Full Name
wingless-type MMTV integration site family, member 6provided by MGI
Primary source
MGI:MGI:98960
See related
Ensembl:ENSMUSG00000033227 AllianceGenome:MGI:98960
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Wnt-6
Summary
Predicted to enable cytokine activity and frizzled binding activity. Acts upstream of or within several processes, including epithelial-mesenchymal cell signaling; nephron tubule morphogenesis; and positive regulation of macromolecule metabolic process. Located in cell surface and extracellular matrix. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; limb; and sensory organ. Orthologous to human WNT6 (Wnt family member 6). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in ovary adult (RPKM 26.4), limb E14.5 (RPKM 9.9) and 8 other tissues See more
Orthologs
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Genomic context

See Wnt6 in Genome Data Viewer
Location:
1 C4; 1 38.54 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (74793499..74824481)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (74754342..74785322)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene cytochrome P450, family 27, subfamily a, polypeptide 1 Neighboring gene protein kinase, AMP-activated, gamma 3 non-catalytic subunit Neighboring gene STARR-seq mESC enhancer starr_01342 Neighboring gene predicted gene 29539 Neighboring gene predicted gene, 32099 Neighboring gene STARR-seq mESC enhancer starr_01343 Neighboring gene wingless-type MMTV integration site family, member 10A Neighboring gene VISTA enhancer mm1017 Neighboring gene nuclear encoded tRNA glycine 3 (anticodon GCC)

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (6)  1 citation
  • Endonuclease-mediated (1) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables cytokine activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables frizzled binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables signaling receptor binding TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within Wnt signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within animal organ morphogenesis TAS
Traceable Author Statement
more info
PubMed 
acts_upstream_of_or_within axis specification IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within branching involved in ureteric bud morphogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in canonical Wnt signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in cell fate commitment IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within cell-cell signaling TAS
Traceable Author Statement
more info
PubMed 
acts_upstream_of_or_within epithelial-mesenchymal cell signaling IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
involved_in multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within nephron tubule development IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within nephron tubule formation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in neuron differentiation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in odontogenesis of dentin-containing tooth ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within positive regulation of gene expression IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of tooth mineralization ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within signal transduction TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
located_in cell surface IDA
Inferred from Direct Assay
more info
PubMed 
located_in endoplasmic reticulum lumen TAS
Traceable Author Statement
more info
 
located_in extracellular matrix IDA
Inferred from Direct Assay
more info
PubMed 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
protein Wnt-6
Names
wingless-related MMTV integration site 6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_009526.3NP_033552.2  protein Wnt-6 precursor

    See identical proteins and their annotated locations for NP_033552.2

    Status: VALIDATED

    Source sequence(s)
    AK133954, AV303464, M89800
    Consensus CDS
    CCDS15056.1
    UniProtKB/Swiss-Prot
    P22727, Q80ZM9
    Related
    ENSMUSP00000006716.7, ENSMUST00000006716.8
    Conserved Domains (1) summary
    cd19338
    Location:34364
    Wnt_Wnt6; Wnt domain found in protein Wnt-6 and similar proteins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    74793499..74824481
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006495887.4XP_006495950.1  protein Wnt-6 isoform X1

    See identical proteins and their annotated locations for XP_006495950.1

    UniProtKB/Swiss-Prot
    P22727, Q80ZM9
    Conserved Domains (1) summary
    cd19338
    Location:34364
    Wnt_Wnt6; Wnt domain found in protein Wnt-6 and similar proteins
  2. XM_006495888.4XP_006495951.1  protein Wnt-6 isoform X1

    See identical proteins and their annotated locations for XP_006495951.1

    UniProtKB/Swiss-Prot
    P22727, Q80ZM9
    Conserved Domains (1) summary
    cd19338
    Location:34364
    Wnt_Wnt6; Wnt domain found in protein Wnt-6 and similar proteins
  3. XM_006495889.3XP_006495952.1  protein Wnt-6 isoform X2

    Conserved Domains (1) summary
    cd19338
    Location:1331
    Wnt_Wnt6; Wnt domain found in protein Wnt-6 and similar proteins