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FES FES proto-oncogene, tyrosine kinase [ Homo sapiens (human) ]

Gene ID: 2242, updated on 12-Aug-2018

Summary

Official Symbol
FESprovided by HGNC
Official Full Name
FES proto-oncogene, tyrosine kinaseprovided by HGNC
Primary source
HGNC:HGNC:3657
See related
Ensembl:ENSG00000182511 MIM:190030; Vega:OTTHUMG00000044456
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FPS
Summary
This gene encodes the human cellular counterpart of a feline sarcoma retrovirus protein with transforming capabilities. The gene product has tyrosine-specific protein kinase activity and that activity is required for maintenance of cellular transformation. Its chromosomal location has linked it to a specific translocation event identified in patients with acute promyelocytic leukemia but it is also involved in normal hematopoiesis as well as growth factor and cytokine receptor signaling. Alternative splicing results in multiple variants encoding different isoforms.[provided by RefSeq, Jan 2009]
Expression
Broad expression in spleen (RPKM 39.1), bone marrow (RPKM 25.6) and 23 other tissues See more
Orthologs

Genomic context

See FES in Genome Data Viewer
Location:
15q26.1
Exon count:
19
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 15 NC_000015.10 (90884421..90895776)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (91427665..91439006)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene RNA, 7SL, cytoplasmic 363, pseudogene Neighboring gene Sharpr-MPRA regulatory regions 3826 and 8172 Neighboring gene furin, paired basic amino acid cleaving enzyme Neighboring gene mannosidase alpha class 2A member 2 Neighboring gene unc-45 myosin chaperone A Neighboring gene HD domain containing 3

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Biological insights from 108 schizophrenia-associated genetic loci.
NHGRI GWA Catalog
Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk.
NHGRI GWA Catalog
Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure.
NHGRI GWA Catalog

Pathways from BioSystems

  • Angiopoietin receptor Tie2-mediated signaling, organism-specific biosystem (from Pathway Interaction Database)
    Angiopoietin receptor Tie2-mediated signaling, organism-specific biosystem
    Angiopoietin receptor Tie2-mediated signaling
  • Axon guidance, organism-specific biosystem (from KEGG)
    Axon guidance, organism-specific biosystemAxon guidance represents a key stage in the formation of neuronal network. Axons are guided by a variety of guidance factors, such as netrins, ephrins, Slits, and semaphorins. These guidance cues are...
  • Axon guidance, conserved biosystem (from KEGG)
    Axon guidance, conserved biosystemAxon guidance represents a key stage in the formation of neuronal network. Axons are guided by a variety of guidance factors, such as netrins, ephrins, Slits, and semaphorins. These guidance cues are...
  • Axon guidance, organism-specific biosystem (from REACTOME)
    Axon guidance, organism-specific biosystemAxon guidance / axon pathfinding is the process by which neurons send out axons to reach the correct targets. Growing axons have a highly motile structure at the growing tip called the growth cone, w...
  • CRMPs in Sema3A signaling, organism-specific biosystem (from REACTOME)
    CRMPs in Sema3A signaling, organism-specific biosystemCRMPs are a small family of plexinA-interacting cytosolic phosphoproteins identified as mediators of Sema3A signaling and neuronal differentiation. After Sema3A activation Plexin-A bound CRMP's under...
  • Developmental Biology, organism-specific biosystem (from REACTOME)
    Developmental Biology, organism-specific biosystemAs a first step towards capturing the array of processes by which a fertilized egg gives rise to the diverse tissues of the body, examples of three kinds of processes have been annotated. These are a...
  • IL-4 Signaling Pathway, organism-specific biosystem (from WikiPathways)
    IL-4 Signaling Pathway, organism-specific biosystemIL-4 is a glycoprotein which is composed of 129 amino acids and has a molecular weight of 20kDa. IL-4 and IL-13 are produced by CD4+ cells and exhibit significant functional overlap. Both these cytok...
  • IL4-mediated signaling events, organism-specific biosystem (from Pathway Interaction Database)
    IL4-mediated signaling events, organism-specific biosystem
    IL4-mediated signaling events
  • Interleukin-11 Signaling Pathway, organism-specific biosystem (from WikiPathways)
    Interleukin-11 Signaling Pathway, organism-specific biosystemIL-11 is a multifunctional cytokine that belongs to the gp130 family. It was first isolated from a primate bone marrow derived cell line, PU-34 for its ability to stimulate the proliferation of a pla...
  • SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion, organism-specific biosystem (from REACTOME)
    SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion, organism-specific biosystemSema3A, a prototypical semaphorin, acts as a chemorepellent or a chemoattractant for axons by activating a receptor complex comprising neuropilin-1 as the ligand-binding subunit and plexin-A1 as the ...
  • Sema3A PAK dependent Axon repulsion, organism-specific biosystem (from REACTOME)
    Sema3A PAK dependent Axon repulsion, organism-specific biosystemActivated Rac1 bound to plexin-A might modulate actin dynamics through the sequential phosphorylation and activation of PAK, LIMK1 and cofilin.
  • Semaphorin interactions, organism-specific biosystem (from REACTOME)
    Semaphorin interactions, organism-specific biosystemSemaphorins are a large family of cell surface and secreted guidance molecules divided into eight classes on the basis of their structures. They all have an N-terminal conserved sema domain. Semaphor...
  • Signal Transduction, organism-specific biosystem (from REACTOME)
    Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
  • Signaling by SCF-KIT, organism-specific biosystem (from REACTOME)
    Signaling by SCF-KIT, organism-specific biosystemStem cell factor (SCF) is a growth factor with membrane bound and soluble forms. It is expressed by fibroblasts and endothelial cells throughout the body, promoting proliferation, migration, survival...
  • Signaling events mediated by VEGFR1 and VEGFR2, organism-specific biosystem (from Pathway Interaction Database)
    Signaling events mediated by VEGFR1 and VEGFR2, organism-specific biosystem
    Signaling events mediated by VEGFR1 and VEGFR2
  • Thymic Stromal LymphoPoietin (TSLP) Signaling Pathway, organism-specific biosystem (from WikiPathways)
    Thymic Stromal LymphoPoietin (TSLP) Signaling Pathway, organism-specific biosystem
    Thymic Stromal LymphoPoietin (TSLP) Signaling Pathway

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
immunoglobulin receptor binding IDA
Inferred from Direct Assay
more info
PubMed 
microtubule binding IEA
Inferred from Electronic Annotation
more info
 
non-membrane spanning protein tyrosine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
non-membrane spanning protein tyrosine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
phosphatidylinositol binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein tyrosine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein tyrosine kinase activity TAS
Traceable Author Statement
more info
 
Process Evidence Code Pubs
cell adhesion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cell proliferation TAS
Traceable Author Statement
more info
PubMed 
centrosome cycle IEA
Inferred from Electronic Annotation
more info
 
chemotaxis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
microtubule bundle formation IEA
Inferred from Electronic Annotation
more info
 
multicellular organism development TAS
Traceable Author Statement
more info
PubMed 
peptidyl-tyrosine phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of actin cytoskeleton reorganization IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of microtubule polymerization IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of myeloid cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of neuron projection development IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein autophosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
protein phosphorylation TAS
Traceable Author Statement
more info
PubMed 
regulation of cell adhesion IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of cell motility IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of cell proliferation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of cell shape IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of mast cell degranulation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of mast cell degranulation IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of vesicle-mediated transport TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
Golgi apparatus IEA
Inferred from Electronic Annotation
more info
 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
colocalizes_with cytoplasmic vesicle IDA
Inferred from Direct Assay
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
extrinsic component of cytoplasmic side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
extrinsic component of cytoplasmic side of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
focal adhesion IDA
Inferred from Direct Assay
more info
PubMed 
microtubule cytoskeleton IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
tyrosine-protein kinase Fes/Fps
Names
Oncogene FES, feline sarcoma virus
feline sarcoma (Snyder-Theilen) viral (v-fes)/Fujinami avian sarcoma (PRCII) viral (v-fps) oncogene homolog
feline sarcoma oncogene
feline sarcoma/Fujinami avian sarcoma oncogene homolog
p93c-fes
proto-oncogene c-Fes
proto-oncogene c-Fps
proto-oncogene tyrosine-protein kinase Fes/Fps
NP_001137255.1
NP_001137256.1
NP_001137257.1
NP_001996.1
XP_005254937.1
XP_005254939.1
XP_016877494.1
XP_016877495.1
XP_016877496.1
XP_016877497.1
XP_016877498.1
XP_016877499.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029671.1 RefSeqGene

    Range
    5001..16319
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001143783.1NP_001137255.1  tyrosine-protein kinase Fes/Fps isoform 2

    See identical proteins and their annotated locations for NP_001137255.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an in-frame exon in the 5' coding region, compared to variant 1, and encodes a protein (isoform 2) with a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AC124248, AY513656
    Consensus CDS
    CCDS45350.1
    UniProtKB/Swiss-Prot
    P07332
    Related
    ENSP00000377837.3, OTTHUMP00000195202, ENST00000394300.7, OTTHUMT00000314024
    Conserved Domains (4) summary
    cd10361
    Location:395479
    SH2_Fps_family; Src homology 2 (SH2) domain found in feline sarcoma, Fujinami poultry sarcoma, and fes-related (Fes/Fps/Fer) proteins
    cd05084
    Location:506757
    PTKc_Fes; Catalytic domain of the Protein Tyrosine Kinase, Fes
    pfam07714
    Location:503756
    Pkinase_Tyr; Protein tyrosine kinase
    cl12013
    Location:7181
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
  2. NM_001143784.1NP_001137256.1  tyrosine-protein kinase Fes/Fps isoform 3

    See identical proteins and their annotated locations for NP_001137256.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an in-frame exon in the 3' coding region, compared to variant 1, and encodes a protein (isoform 3) with a shorter C-terminus and an incomplete SH2 domain, compared to isoform 1.
    Source sequence(s)
    AC124248, AY513657
    Consensus CDS
    CCDS45349.1
    UniProtKB/Swiss-Prot
    P07332
    Related
    ENSP00000400868.2, OTTHUMP00000233984, ENST00000444422.2, OTTHUMT00000391051
    Conserved Domains (3) summary
    cd05084
    Location:494745
    PTKc_Fes; Catalytic domain of the Protein Tyrosine Kinase, Fes
    pfam07714
    Location:491744
    Pkinase_Tyr; Protein tyrosine kinase
    cl12013
    Location:7239
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
  3. NM_001143785.1NP_001137257.1  tyrosine-protein kinase Fes/Fps isoform 4

    See identical proteins and their annotated locations for NP_001137257.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks multiple in-frame exons in the coding region, compared to variant 1, and encodes a shorter protein (isoform 4) with an incomplete SH2 domain, compared to isoform 1.
    Source sequence(s)
    AC124248, AY513654, DB264752
    Consensus CDS
    CCDS45351.1
    UniProtKB/Swiss-Prot
    P07332
    Related
    ENSP00000414629.2, OTTHUMP00000233982, ENST00000414248.6, OTTHUMT00000391050
    Conserved Domains (3) summary
    cd05084
    Location:436687
    PTKc_Fes; Catalytic domain of the Protein Tyrosine Kinase, Fes
    pfam07714
    Location:433686
    Pkinase_Tyr; Protein tyrosine kinase
    cl12013
    Location:7181
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
  4. NM_002005.3NP_001996.1  tyrosine-protein kinase Fes/Fps isoform 1

    See identical proteins and their annotated locations for NP_001996.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC124248, DA782386, X52192
    Consensus CDS
    CCDS10365.1
    UniProtKB/Swiss-Prot
    P07332
    UniProtKB/TrEMBL
    A0A024RC92
    Related
    ENSP00000331504.3, OTTHUMP00000194752, ENST00000328850.7, OTTHUMT00000313497
    Conserved Domains (4) summary
    cd07685
    Location:7239
    F-BAR_Fes; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Fes (feline sarcoma) tyrosine kinase
    cd10361
    Location:453537
    SH2_Fps_family; Src homology 2 (SH2) domain found in feline sarcoma, Fujinami poultry sarcoma, and fes-related (Fes/Fps/Fer) proteins
    cd05084
    Location:564815
    PTKc_Fes; Catalytic domain of the Protein Tyrosine Kinase, Fes
    pfam07714
    Location:561814
    Pkinase_Tyr; Protein tyrosine kinase

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p12 Primary Assembly

    Range
    90884421..90895776
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017022008.1XP_016877497.1  tyrosine-protein kinase Fes/Fps isoform X4

    UniProtKB/Swiss-Prot
    P07332
    Conserved Domains (3) summary
    cd05084
    Location:436687
    PTKc_Fes; Catalytic domain of the Protein Tyrosine Kinase, Fes
    pfam07714
    Location:433686
    Pkinase_Tyr; Protein tyrosine kinase
    cl12013
    Location:7181
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
  2. XM_017022006.1XP_016877495.1  tyrosine-protein kinase Fes/Fps isoform X2

    UniProtKB/Swiss-Prot
    P07332
    Conserved Domains (4) summary
    cd10361
    Location:395479
    SH2_Fps_family; Src homology 2 (SH2) domain found in feline sarcoma, Fujinami poultry sarcoma, and fes-related (Fes/Fps/Fer) proteins
    cd05084
    Location:506757
    PTKc_Fes; Catalytic domain of the Protein Tyrosine Kinase, Fes
    pfam07714
    Location:503756
    Pkinase_Tyr; Protein tyrosine kinase
    cl12013
    Location:7181
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
  3. XM_017022009.2XP_016877498.1  tyrosine-protein kinase Fes/Fps isoform X1

    UniProtKB/Swiss-Prot
    P07332
    UniProtKB/TrEMBL
    A0A024RC92
    Conserved Domains (4) summary
    cd07685
    Location:7239
    F-BAR_Fes; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Fes (feline sarcoma) tyrosine kinase
    cd10361
    Location:453537
    SH2_Fps_family; Src homology 2 (SH2) domain found in feline sarcoma, Fujinami poultry sarcoma, and fes-related (Fes/Fps/Fer) proteins
    cd05084
    Location:564815
    PTKc_Fes; Catalytic domain of the Protein Tyrosine Kinase, Fes
    pfam07714
    Location:561814
    Pkinase_Tyr; Protein tyrosine kinase
  4. XM_017022010.1XP_016877499.1  tyrosine-protein kinase Fes/Fps isoform X2

    UniProtKB/Swiss-Prot
    P07332
    Conserved Domains (4) summary
    cd10361
    Location:395479
    SH2_Fps_family; Src homology 2 (SH2) domain found in feline sarcoma, Fujinami poultry sarcoma, and fes-related (Fes/Fps/Fer) proteins
    cd05084
    Location:506757
    PTKc_Fes; Catalytic domain of the Protein Tyrosine Kinase, Fes
    pfam07714
    Location:503756
    Pkinase_Tyr; Protein tyrosine kinase
    cl12013
    Location:7181
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
  5. XM_005254882.2XP_005254939.1  tyrosine-protein kinase Fes/Fps isoform X3

    See identical proteins and their annotated locations for XP_005254939.1

    UniProtKB/Swiss-Prot
    P07332
    Conserved Domains (3) summary
    cd05084
    Location:494745
    PTKc_Fes; Catalytic domain of the Protein Tyrosine Kinase, Fes
    pfam07714
    Location:491744
    Pkinase_Tyr; Protein tyrosine kinase
    cl12013
    Location:7239
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
  6. XM_005254880.1XP_005254937.1  tyrosine-protein kinase Fes/Fps isoform X2

    See identical proteins and their annotated locations for XP_005254937.1

    UniProtKB/Swiss-Prot
    P07332
    Conserved Domains (4) summary
    cd10361
    Location:395479
    SH2_Fps_family; Src homology 2 (SH2) domain found in feline sarcoma, Fujinami poultry sarcoma, and fes-related (Fes/Fps/Fer) proteins
    cd05084
    Location:506757
    PTKc_Fes; Catalytic domain of the Protein Tyrosine Kinase, Fes
    pfam07714
    Location:503756
    Pkinase_Tyr; Protein tyrosine kinase
    cl12013
    Location:7181
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
  7. XM_017022005.1XP_016877494.1  tyrosine-protein kinase Fes/Fps isoform X1

    UniProtKB/Swiss-Prot
    P07332
    UniProtKB/TrEMBL
    A0A024RC92
    Conserved Domains (4) summary
    cd07685
    Location:7239
    F-BAR_Fes; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Fes (feline sarcoma) tyrosine kinase
    cd10361
    Location:453537
    SH2_Fps_family; Src homology 2 (SH2) domain found in feline sarcoma, Fujinami poultry sarcoma, and fes-related (Fes/Fps/Fer) proteins
    cd05084
    Location:564815
    PTKc_Fes; Catalytic domain of the Protein Tyrosine Kinase, Fes
    pfam07714
    Location:561814
    Pkinase_Tyr; Protein tyrosine kinase
  8. XM_017022007.1XP_016877496.1  tyrosine-protein kinase Fes/Fps isoform X3

    UniProtKB/Swiss-Prot
    P07332
    Conserved Domains (3) summary
    cd05084
    Location:494745
    PTKc_Fes; Catalytic domain of the Protein Tyrosine Kinase, Fes
    pfam07714
    Location:491744
    Pkinase_Tyr; Protein tyrosine kinase
    cl12013
    Location:7239
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

RNA

  1. XR_001751144.2 RNA Sequence

    Related
    ENST00000464684.5
  2. XR_243206.3 RNA Sequence

  3. XR_001751142.1 RNA Sequence

  4. XR_001751143.1 RNA Sequence

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