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Dzip3 DAZ interacting protein 3, zinc finger [ Mus musculus (house mouse) ]

Gene ID: 224170, updated on 5-Mar-2024

Summary

Official Symbol
Dzip3provided by MGI
Official Full Name
DAZ interacting protein 3, zinc fingerprovided by MGI
Primary source
MGI:MGI:1917433
See related
Ensembl:ENSMUSG00000064061 AllianceGenome:MGI:1917433
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
2A-HUB; A230104G20; 2310047C04Rik; 6430549P11Rik
Summary
Predicted to enable several functions, including phosphatase binding activity; polyubiquitin modification-dependent protein binding activity; and ubiquitin-protein transferase activity. Predicted to be involved in protein polyubiquitination. Predicted to be active in cytoplasm. Orthologous to human DZIP3 (DAZ interacting zinc finger protein 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in CNS E18 (RPKM 15.0), CNS E14 (RPKM 12.5) and 15 other tissues See more
Orthologs
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Genomic context

See Dzip3 in Genome Data Viewer
Location:
16 B5; 16 30.75 cM
Exon count:
33
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (48744591..48814505, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (48924228..48994142, complement)

Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene resistin like alpha Neighboring gene STARR-seq mESC enhancer starr_40961 Neighboring gene resistin like gamma Neighboring gene STARR-seq mESC enhancer starr_40962 Neighboring gene STARR-positive B cell enhancer mm9_chr16:48942004-48942304 Neighboring gene predicted gene, 22576 Neighboring gene STARR-seq mESC enhancer starr_40963 Neighboring gene STARR-seq mESC enhancer starr_40964 Neighboring gene cell proliferation regulating inhibitor of protein phosphatase 2A Neighboring gene myosin, heavy chain 15 Neighboring gene STARR-positive B cell enhancer mm9_chr16:49164447-49164748

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Chemically induced (ENU) (1) 
  • Endonuclease-mediated (4) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables RNA binding ISO
Inferred from Sequence Orthology
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables phosphatase binding ISO
Inferred from Sequence Orthology
more info
 
enables polyubiquitin modification-dependent protein binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables polyubiquitin modification-dependent protein binding ISO
Inferred from Sequence Orthology
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
enables ubiquitin protein ligase activity IEA
Inferred from Electronic Annotation
more info
 
enables ubiquitin-protein transferase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables ubiquitin-protein transferase activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in protein polyubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in protein polyubiquitination ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
E3 ubiquitin-protein ligase DZIP3
Names
DAZ-interacting protein 3 homolog
RING-type E3 ubiquitin transferase DZIP3
NP_001103487.1
NP_001343354.1
NP_081617.1
XP_017172456.1
XP_030104951.1
XP_030104952.1
XP_030104953.1
XP_030104954.1
XP_036015793.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001110017.2NP_001103487.1  E3 ubiquitin-protein ligase DZIP3 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AC154447
    Consensus CDS
    CCDS49866.1
    UniProtKB/Swiss-Prot
    Q148V3, Q7TPV2, Q80TU4, Q8BYK7
    UniProtKB/TrEMBL
    E9QNZ2
    Related
    ENSMUSP00000113344.2, ENSMUST00000121869.8
    Conserved Domains (2) summary
    pfam12678
    Location:11431184
    zf-rbx1; RING-H2 zinc finger
    pfam13639
    Location:11441184
    zf-RING_2; Ring finger domain
  2. NM_001356425.1NP_001343354.1  E3 ubiquitin-protein ligase DZIP3 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC154447
    UniProtKB/Swiss-Prot
    Q148V3, Q7TPV2, Q80TU4, Q8BYK7
    Conserved Domains (2) summary
    cl17238
    Location:11431168
    RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain
    cl25732
    Location:744931
    SMC_N; RecF/RecN/SMC N terminal domain
  3. NM_027341.2NP_081617.1  E3 ubiquitin-protein ligase DZIP3 isoform 2

    See identical proteins and their annotated locations for NP_081617.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an in-frame exon in the coding region, compared to variant 1. It encodes an isoform (2) which is shorter than isoform 1.
    Source sequence(s)
    AK163763, BC117954, CJ122641
    Consensus CDS
    CCDS37353.1
    UniProtKB/Swiss-Prot
    Q148V3, Q7TPV2, Q80TU4, Q8BYK7
    Related
    ENSMUSP00000110161.2, ENSMUST00000114516.8
    Conserved Domains (2) summary
    pfam12678
    Location:937978
    zf-rbx1; RING-H2 zinc finger
    pfam13639
    Location:938978
    zf-RING_2; Ring finger domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000082.7 Reference GRCm39 C57BL/6J

    Range
    48744591..48814505 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017316967.2XP_017172456.1  E3 ubiquitin-protein ligase DZIP3 isoform X1

    Conserved Domains (2) summary
    COG1196
    Location:538725
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cl17238
    Location:937962
    RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain
  2. XM_036159900.1XP_036015793.1  E3 ubiquitin-protein ligase DZIP3 isoform X5

    Conserved Domains (3) summary
    COG1196
    Location:191378
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    COG5540
    Location:499637
    COG5540; RING-finger-containing ubiquitin ligase [Posttranslational modification, protein turnover, chaperones]
    cd16460
    Location:589631
    RING-H2_DZIP3; RING finger, H2 subclass, found in DAZ (deleted in azoospermia)-interacting protein 3 (DZIP3) and similar proteins
  3. XM_030249092.1XP_030104952.1  E3 ubiquitin-protein ligase DZIP3 isoform X3

    Conserved Domains (4) summary
    COG1196
    Location:397584
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    COG5540
    Location:705843
    COG5540; RING-finger-containing ubiquitin ligase [Posttranslational modification, protein turnover, chaperones]
    cd16460
    Location:795837
    RING-H2_DZIP3; RING finger, H2 subclass, found in DAZ (deleted in azoospermia)-interacting protein 3 (DZIP3) and similar proteins
    pfam18738
    Location:74217
    HEPN_DZIP3; DZIP3/ hRUL138-like HEPN
  4. XM_030249093.1XP_030104953.1  E3 ubiquitin-protein ligase DZIP3 isoform X3

    Conserved Domains (4) summary
    COG1196
    Location:397584
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    COG5540
    Location:705843
    COG5540; RING-finger-containing ubiquitin ligase [Posttranslational modification, protein turnover, chaperones]
    cd16460
    Location:795837
    RING-H2_DZIP3; RING finger, H2 subclass, found in DAZ (deleted in azoospermia)-interacting protein 3 (DZIP3) and similar proteins
    pfam18738
    Location:74217
    HEPN_DZIP3; DZIP3/ hRUL138-like HEPN
  5. XM_030249094.1XP_030104954.1  E3 ubiquitin-protein ligase DZIP3 isoform X4

    Conserved Domains (3) summary
    COG1196
    Location:291478
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    COG5540
    Location:599737
    COG5540; RING-finger-containing ubiquitin ligase [Posttranslational modification, protein turnover, chaperones]
    cd16460
    Location:689731
    RING-H2_DZIP3; RING finger, H2 subclass, found in DAZ (deleted in azoospermia)-interacting protein 3 (DZIP3) and similar proteins
  6. XM_030249091.1XP_030104951.1  E3 ubiquitin-protein ligase DZIP3 isoform X2

    Conserved Domains (4) summary
    COG1196
    Location:497684
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    COG5540
    Location:805943
    COG5540; RING-finger-containing ubiquitin ligase [Posttranslational modification, protein turnover, chaperones]
    cd16460
    Location:895937
    RING-H2_DZIP3; RING finger, H2 subclass, found in DAZ (deleted in azoospermia)-interacting protein 3 (DZIP3) and similar proteins
    pfam18738
    Location:174317
    HEPN_DZIP3; DZIP3/ hRUL138-like HEPN

RNA

  1. XR_001781815.2 RNA Sequence

  2. XR_001781814.2 RNA Sequence

  3. XR_003951784.1 RNA Sequence