U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Wnt4 wingless-type MMTV integration site family, member 4 [ Mus musculus (house mouse) ]

Gene ID: 22417, updated on 29-May-2024

Summary

Official Symbol
Wnt4provided by MGI
Official Full Name
wingless-type MMTV integration site family, member 4provided by MGI
Primary source
MGI:MGI:98957
See related
Ensembl:ENSMUSG00000036856 AllianceGenome:MGI:98957
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Wnt-4
Summary
Enables frizzled binding activity and transcription corepressor activity. Involved in several processes, including paramesonephric duct development; positive regulation of cellular component biogenesis; and regulation of cellular biosynthetic process. Acts upstream of or within several processes, including animal organ development; negative regulation of signal transduction; and renal vesicle induction. Located in cell surface; extracellular matrix; and extracellular space. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; limb; and sensory organ. Human ortholog(s) of this gene implicated in Mullerian aplasia and hyperandrogenism. Orthologous to human WNT4 (Wnt family member 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in adrenal adult (RPKM 48.0), ovary adult (RPKM 25.7) and 13 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Wnt4 in Genome Data Viewer
Location:
4 D3; 4 69.8 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (137004946..137026812)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (137277635..137299501)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 46872 Neighboring gene predicted gene, 31820 Neighboring gene chromobox homolog 5 pseudogene Neighboring gene cell division cycle 42 Neighboring gene STARR-positive B cell enhancer ABC_E10268 Neighboring gene STARR-positive B cell enhancer ABC_E1661 Neighboring gene RIKEN cDNA 2810405F17 gene Neighboring gene STARR-seq mESC enhancer starr_11776 Neighboring gene predicted gene, 52681

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC123964

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables cytokine activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables frizzled binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables frizzled binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables receptor ligand activity ISO
Inferred from Sequence Orthology
more info
 
enables signaling receptor binding TAS
Traceable Author Statement
more info
PubMed 
enables transcription corepressor activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within Sertoli cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within T cell differentiation in thymus IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within anatomical structure development IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of apoptotic signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within branching involved in ureteric bud morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within branching morphogenesis of an epithelial tube IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in canonical Wnt signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within canonical Wnt signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in canonical Wnt signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within canonical Wnt signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in canonical Wnt signaling pathway ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cell fate commitment IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within cell fate commitment IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within cell-cell signaling TAS
Traceable Author Statement
more info
PubMed 
acts_upstream_of_or_within cellular response to starvation IEP
Inferred from Expression Pattern
more info
PubMed 
acts_upstream_of_or_within embryonic epithelial tube formation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within female gonad development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in female sex determination ISO
Inferred from Sequence Orthology
more info
 
involved_in female sex determination ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
acts_upstream_of fibroblast growth factor receptor signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within gamete generation IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within hormone metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within immature T cell proliferation in thymus IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within kidney morphogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within male gonad development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in male gonad development ISO
Inferred from Sequence Orthology
more info
 
involved_in male gonad development ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
acts_upstream_of meiotic nuclear division IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within mesenchymal to epithelial transition IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within mesonephric tubule development IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in mesonephros development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in metanephric mesenchymal cell differentiation NAS
Non-traceable Author Statement
more info
PubMed 
acts_upstream_of_or_within metanephric nephron development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within metanephric nephron morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within metanephric tubule formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within metanephros development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within metanephros development TAS
Traceable Author Statement
more info
PubMed 
acts_upstream_of_or_within multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
involved_in multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of DNA-templated transcription IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of DNA-templated transcription ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
involved_in negative regulation of androgen biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of apoptotic signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within negative regulation of cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of cell migration IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within negative regulation of fibroblast growth factor receptor signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within negative regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of male gonad development ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of steroid biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of testicular blood vessel morphogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of testosterone biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of testosterone biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of wound healing IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within nephron development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in neuron differentiation IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within non-canonical Wnt signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in non-canonical Wnt signaling pathway ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within oocyte development IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within oocyte development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within paramesonephric duct development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in paramesonephric duct development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in paramesonephric duct development ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within pericyte cell differentiation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within pericyte cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of DNA-templated transcription IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of GTPase activity IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of MAPK cascade ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of aldosterone biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of bone mineralization ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of collagen biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cortisol biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of dermatome development ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of dermatome development ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
involved_in positive regulation of focal adhesion assembly IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within positive regulation of meiotic nuclear division IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of osteoblast differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of stress fiber assembly IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within regulation of cell-cell adhesion IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within renal vesicle formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within renal vesicle induction IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within sex differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within signal transduction TAS
Traceable Author Statement
more info
PubMed 
acts_upstream_of_or_within smooth muscle cell differentiation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within smooth muscle cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within somatotropin secreting cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within tertiary branching involved in mammary gland duct morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within thyroid-stimulating hormone-secreting cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within tube morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in cell surface IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in endoplasmic reticulum lumen TAS
Traceable Author Statement
more info
 
located_in extracellular matrix IDA
Inferred from Direct Assay
more info
PubMed 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 
located_in extracellular region TAS
Traceable Author Statement
more info
 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
protein Wnt-4
Names
signal molecule
wingless-related MMTV integration site 4

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_009523.2NP_033549.1  protein Wnt-4 precursor

    See identical proteins and their annotated locations for NP_033549.1

    Status: VALIDATED

    Source sequence(s)
    AL645468, M89797
    Consensus CDS
    CCDS18815.1
    UniProtKB/Swiss-Prot
    P22724
    UniProtKB/TrEMBL
    Q3ZB23
    Related
    ENSMUSP00000036580.5, ENSMUST00000045747.5
    Conserved Domains (1) summary
    cd19336
    Location:43351
    Wnt_Wnt4; Wnt domain found in protein Wnt-4 and similar proteins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    137004946..137026812
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)