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Wnt4 wingless-type MMTV integration site family, member 4 [ Mus musculus (house mouse) ]

Gene ID: 22417, updated on 22-Oct-2019

Summary

Official Symbol
Wnt4provided by MGI
Official Full Name
wingless-type MMTV integration site family, member 4provided by MGI
Primary source
MGI:MGI:98957
See related
Ensembl:ENSMUSG00000036856
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Wnt-4
Expression
Biased expression in adrenal adult (RPKM 48.0), ovary adult (RPKM 25.7) and 13 other tissues See more
Orthologs

Genomic context

See Wnt4 in Genome Data Viewer
Location:
4; 4 D3
Exon count:
5
Annotation release Status Assembly Chr Location
108 current GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (137277635..137299501)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 4 NC_000070.5 (136833550..136852694)

Chromosome 4 - NC_000070.6Genomic Context describing neighboring genes Neighboring gene predicted gene, 46872 Neighboring gene predicted gene, 31820 Neighboring gene chromobox homolog 5 pseudogene Neighboring gene cell division cycle 42 Neighboring gene uncharacterized LOC115489905

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from BioSystems

  • Axon guidance, organism-specific biosystem (from KEGG)
    Axon guidance, organism-specific biosystemAxon guidance represents a key stage in the formation of neuronal network. Axons are guided by a variety of guidance factors, such as netrins, ephrins, Slits, and semaphorins. These guidance cues are...
  • Axon guidance, conserved biosystem (from KEGG)
    Axon guidance, conserved biosystemAxon guidance represents a key stage in the formation of neuronal network. Axons are guided by a variety of guidance factors, such as netrins, ephrins, Slits, and semaphorins. These guidance cues are...
  • Basal cell carcinoma, organism-specific biosystem (from KEGG)
    Basal cell carcinoma, organism-specific biosystemCancer of the skin is the most common cancer in Caucasians and basal cell carcinomas (BCC) account for 90% of all skin cancers. The vast majority of BCC cases are sporadic, though there is a rare fam...
  • Basal cell carcinoma, conserved biosystem (from KEGG)
    Basal cell carcinoma, conserved biosystemCancer of the skin is the most common cancer in Caucasians and basal cell carcinomas (BCC) account for 90% of all skin cancers. The vast majority of BCC cases are sporadic, though there is a rare fam...
  • Breast cancer, organism-specific biosystem (from KEGG)
    Breast cancer, organism-specific biosystemBreast cancer is the leading cause of cancer death among women worldwide. The vast majority of breast cancers are carcinomas that originate from cells lining the milk-forming ducts of the mammary gla...
  • Breast cancer, conserved biosystem (from KEGG)
    Breast cancer, conserved biosystemBreast cancer is the leading cause of cancer death among women worldwide. The vast majority of breast cancers are carcinomas that originate from cells lining the milk-forming ducts of the mammary gla...
  • ESC Pluripotency Pathways, organism-specific biosystem (from WikiPathways)
    ESC Pluripotency Pathways, organism-specific biosystemThe cytokine LIF and its downstream effector STAT3 are essential for maintenance of pluripotency in mouse ES cells. The requirement for the transcription factor Oct3/4 for ES cell pluripotency is als...
  • HTLV-I infection, organism-specific biosystem (from KEGG)
    HTLV-I infection, organism-specific biosystemHuman T-lymphotropic virus type 1 (HTLV-1) is a pathogenic retrovirus that is associated with adult T-cell leukemia/lymphoma (ATL). It is also strongly implicated in non-neoplastic chronic inflammato...
  • HTLV-I infection, conserved biosystem (from KEGG)
    HTLV-I infection, conserved biosystemHuman T-lymphotropic virus type 1 (HTLV-1) is a pathogenic retrovirus that is associated with adult T-cell leukemia/lymphoma (ATL). It is also strongly implicated in non-neoplastic chronic inflammato...
  • Hippo signaling pathway, organism-specific biosystem (from KEGG)
    Hippo signaling pathway, organism-specific biosystemHippo signaling is an evolutionarily conserved signaling pathway that controls organ size from flies to humans. In humans and mice, the pathway consists of the MST1 and MST2 kinases, their cofactor S...
  • Hippo signaling pathway, conserved biosystem (from KEGG)
    Hippo signaling pathway, conserved biosystemHippo signaling is an evolutionarily conserved signaling pathway that controls organ size from flies to humans. In humans and mice, the pathway consists of the MST1 and MST2 kinases, their cofactor S...
  • Melanogenesis, organism-specific biosystem (from KEGG)
    Melanogenesis, organism-specific biosystemCutaneous melanin pigment plays a critical role in camouflage, mimicry, social communication, and protection against harmful effects of solar radiation. Melanogenesis is under complex regulatory cont...
  • Melanogenesis, conserved biosystem (from KEGG)
    Melanogenesis, conserved biosystemCutaneous melanin pigment plays a critical role in camouflage, mimicry, social communication, and protection against harmful effects of solar radiation. Melanogenesis is under complex regulatory cont...
  • Negative regulation of TCF-dependent signaling by WNT ligand antagonists, organism-specific biosystem (from REACTOME)
    Negative regulation of TCF-dependent signaling by WNT ligand antagonists, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Nephronophthisis and Wnt Signaling, organism-specific biosystem (from WikiPathways)
    Nephronophthisis and Wnt Signaling, organism-specific biosystemThis pathway is modeled after Figure 5 of the article "Glomerulocystic kidney disease" (Bissler, et al. 2010). The gene product Wnt signals two different paths titled canonical and non-canonical. The...
  • Pathways in cancer, organism-specific biosystem (from KEGG)
    Pathways in cancer, organism-specific biosystem
    Pathways in cancer
  • Proteoglycans in cancer, organism-specific biosystem (from KEGG)
    Proteoglycans in cancer, organism-specific biosystemMany proteoglycans (PGs) in the tumor microenvironment have been shown to be key macromolecules that contribute to biology of various types of cancer including proliferation, adhesion, angiogenesis a...
  • Proteoglycans in cancer, conserved biosystem (from KEGG)
    Proteoglycans in cancer, conserved biosystemMany proteoglycans (PGs) in the tumor microenvironment have been shown to be key macromolecules that contribute to biology of various types of cancer including proliferation, adhesion, angiogenesis a...
  • Signal Transduction, organism-specific biosystem (from REACTOME)
    Signal Transduction, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Signaling by Wnt, organism-specific biosystem (from REACTOME)
    Signaling by Wnt, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Signaling pathways regulating pluripotency of stem cells, organism-specific biosystem (from KEGG)
    Signaling pathways regulating pluripotency of stem cells, organism-specific biosystemPluripotent stem cells (PSCs) are basic cells with an indefinite self-renewal capacity and the potential to generate all the cell types of the three germinal layers. The types of PSCs known to date i...
  • Signaling pathways regulating pluripotency of stem cells, conserved biosystem (from KEGG)
    Signaling pathways regulating pluripotency of stem cells, conserved biosystemPluripotent stem cells (PSCs) are basic cells with an indefinite self-renewal capacity and the potential to generate all the cell types of the three germinal layers. The types of PSCs known to date i...
  • TCF dependent signaling in response to WNT, organism-specific biosystem (from REACTOME)
    TCF dependent signaling in response to WNT, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Thyroid hormone signaling pathway, organism-specific biosystem (from KEGG)
    Thyroid hormone signaling pathway, organism-specific biosystemThe thyroid hormones (THs) are important regulators of growth, development and metabolism. The action of TH is mainly mediated by T3 (3,5,3'-triiodo-L-thyronine). Thyroid hormones, L-thyroxine (T4) a...
  • WNT ligand biogenesis and trafficking, organism-specific biosystem (from REACTOME)
    WNT ligand biogenesis and trafficking, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Wnt Signaling Pathway, organism-specific biosystem (from WikiPathways)
    Wnt Signaling Pathway, organism-specific biosystemWnt proteins are secreted morphogens that are required for basic developmental processes, such as cell-fate specification, progenitor-cell proliferation and the control of asymmetric cell division, i...
  • Wnt Signaling Pathway NetPath, organism-specific biosystem (from WikiPathways)
    Wnt Signaling Pathway NetPath, organism-specific biosystemWnt family of proteins are a large family of cysteine-rich secreted glycoproteins that regulate cell-cell interactions. They bind to members of the Frizzled family of 7 transmembrane receptors. Bindi...
  • Wnt Signaling Pathway and Pluripotency, organism-specific biosystem (from WikiPathways)
    Wnt Signaling Pathway and Pluripotency, organism-specific biosystemThis pathway was adapted from several resources and is designed to provide a theoretical frame-work for examining Wnt signaling and interacting components in the context of embryonic stem-cell pluri...
  • Wnt signaling, organism-specific biosystem (from KEGG)
    Wnt signaling, organism-specific biosystemFunctional set; Cellular processes; Cell signaling
  • Wnt signaling, conserved biosystem (from KEGG)
    Wnt signaling, conserved biosystemFunctional set; Cellular processes; Cell signaling
  • Wnt signaling pathway, organism-specific biosystem (from KEGG)
    Wnt signaling pathway, organism-specific biosystemWnt proteins are secreted morphogens that are required for basic developmental processes, such as cell-fate specification, progenitor-cell proliferation and the control of asymmetric cell division, i...
  • Wnt signaling pathway, conserved biosystem (from KEGG)
    Wnt signaling pathway, conserved biosystemWnt proteins are secreted morphogens that are required for basic developmental processes, such as cell-fate specification, progenitor-cell proliferation and the control of asymmetric cell division, i...
  • mTOR signaling pathway, organism-specific biosystem (from KEGG)
    mTOR signaling pathway, organism-specific biosystemThe mammalian (mechanistic) target of rapamycin (mTOR) is a highly conserved serine/threonine protein kinase, which exists in two complexes termed mTOR complex 1 (mTORC1) and 2 (mTORC2). mTORC1 conta...
  • mTOR signaling pathway, conserved biosystem (from KEGG)
    mTOR signaling pathway, conserved biosystemThe mammalian (mechanistic) target of rapamycin (mTOR) is a highly conserved serine/threonine protein kinase, which exists in two complexes termed mTOR complex 1 (mTORC1) and 2 (mTORC2). mTORC1 conta...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC123964

Gene Ontology Provided by MGI

Function Evidence Code Pubs
frizzled binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
frizzled binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
receptor ligand activity ISO
Inferred from Sequence Orthology
more info
 
signaling receptor binding TAS
Traceable Author Statement
more info
PubMed 
transcription corepressor activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
T cell differentiation in thymus IDA
Inferred from Direct Assay
more info
PubMed 
Wnt signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
anatomical structure development IGI
Inferred from Genetic Interaction
more info
PubMed 
branching involved in ureteric bud morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
branching morphogenesis of an epithelial tube IGI
Inferred from Genetic Interaction
more info
PubMed 
canonical Wnt signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
canonical Wnt signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
canonical Wnt signaling pathway ISO
Inferred from Sequence Orthology
more info
 
cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
cell fate commitment IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cell fate commitment IMP
Inferred from Mutant Phenotype
more info
PubMed 
cell-cell signaling TAS
Traceable Author Statement
more info
PubMed 
cellular response to starvation IEP
Inferred from Expression Pattern
more info
PubMed 
embryonic epithelial tube formation IDA
Inferred from Direct Assay
more info
PubMed 
female gonad development IMP
Inferred from Mutant Phenotype
more info
PubMed 
female sex determination ISO
Inferred from Sequence Orthology
more info
 
female sex determination ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
gamete generation IGI
Inferred from Genetic Interaction
more info
PubMed 
hormone metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
immature T cell proliferation in thymus IMP
Inferred from Mutant Phenotype
more info
PubMed 
kidney morphogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
male gonad development IMP
Inferred from Mutant Phenotype
more info
PubMed 
male gonad development ISO
Inferred from Sequence Orthology
more info
 
male gonad development ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
mesenchymal to epithelial transition IMP
Inferred from Mutant Phenotype
more info
PubMed 
mesonephric tubule development IGI
Inferred from Genetic Interaction
more info
PubMed 
mesonephros development IMP
Inferred from Mutant Phenotype
more info
PubMed 
metanephric mesenchymal cell differentiation NAS
Non-traceable Author Statement
more info
PubMed 
metanephric nephron development IMP
Inferred from Mutant Phenotype
more info
PubMed 
metanephric nephron morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
metanephric tubule formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
metanephros development IMP
Inferred from Mutant Phenotype
more info
PubMed 
metanephros development TAS
Traceable Author Statement
more info
PubMed 
multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
negative regulation of androgen biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
negative regulation of apoptotic signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
negative regulation of cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of cell migration IGI
Inferred from Genetic Interaction
more info
PubMed 
negative regulation of fibroblast growth factor receptor signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
negative regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
negative regulation of male gonad development ISO
Inferred from Sequence Orthology
more info
 
negative regulation of steroid biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
negative regulation of testicular blood vessel morphogenesis ISO
Inferred from Sequence Orthology
more info
 
negative regulation of testosterone biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of testosterone biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
negative regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of transcription, DNA-templated IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of transcription, DNA-templated ISO
Inferred from Sequence Orthology
more info
 
negative regulation of transcription, DNA-templated ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
negative regulation of wound healing IGI
Inferred from Genetic Interaction
more info
PubMed 
nephron development IMP
Inferred from Mutant Phenotype
more info
PubMed 
neuron differentiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
non-canonical Wnt signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
non-canonical Wnt signaling pathway via MAPK cascade ISO
Inferred from Sequence Orthology
more info
 
oocyte development IGI
Inferred from Genetic Interaction
more info
PubMed 
oocyte development IMP
Inferred from Mutant Phenotype
more info
PubMed 
paramesonephric duct development IMP
Inferred from Mutant Phenotype
more info
PubMed 
paramesonephric duct development ISO
Inferred from Sequence Orthology
more info
 
positive regulation of GTPase activity IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of aldosterone biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
positive regulation of bone mineralization ISO
Inferred from Sequence Orthology
more info
 
positive regulation of collagen biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cortisol biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
positive regulation of dermatome development ISO
Inferred from Sequence Orthology
more info
 
positive regulation of dermatome development ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
positive regulation of focal adhesion assembly IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of meiotic nuclear division IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of osteoblast differentiation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of stress fiber assembly IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of transcription, DNA-templated IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of transcription, DNA-templated ISO
Inferred from Sequence Orthology
more info
 
regulation of cell-cell adhesion IMP
Inferred from Mutant Phenotype
more info
PubMed 
renal vesicle formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
renal vesicle induction IDA
Inferred from Direct Assay
more info
PubMed 
sex differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
signal transduction TAS
Traceable Author Statement
more info
PubMed 
smooth muscle cell differentiation IDA
Inferred from Direct Assay
more info
PubMed 
smooth muscle cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
somatotropin secreting cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
tertiary branching involved in mammary gland duct morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
thyroid-stimulating hormone-secreting cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
tube morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
Golgi apparatus ISO
Inferred from Sequence Orthology
more info
 
cell surface IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
extracellular matrix IDA
Inferred from Direct Assay
more info
PubMed 
extracellular region IEA
Inferred from Electronic Annotation
more info
 
extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
extracellular space ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
protein Wnt-4
Names
signal molecule
wingless-related MMTV integration site 4

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_009523.2NP_033549.1  protein Wnt-4 precursor

    See identical proteins and their annotated locations for NP_033549.1

    Status: VALIDATED

    Source sequence(s)
    AL645468, M89797
    Consensus CDS
    CCDS18815.1
    UniProtKB/Swiss-Prot
    P22724
    UniProtKB/TrEMBL
    Q3ZB23
    Related
    ENSMUSP00000036580.4, ENSMUST00000045747.4
    Conserved Domains (1) summary
    pfam00110
    Location:45351
    wnt; wnt family

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p6 C57BL/6J

Genomic

  1. NC_000070.6 Reference GRCm38.p6 C57BL/6J

    Range
    137277635..137299501
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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