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Ubxn7 UBX domain protein 7 [ Mus musculus (house mouse) ]

Gene ID: 224111, updated on 6-Jun-2024

Summary

Official Symbol
Ubxn7provided by MGI
Official Full Name
UBX domain protein 7provided by MGI
Primary source
MGI:MGI:2146388
See related
Ensembl:ENSMUSG00000053774 AllianceGenome:MGI:2146388
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ubxd7; mKIAA0794; A630090P18
Summary
Predicted to enable ubiquitin binding activity and ubiquitin protein ligase binding activity. Predicted to be located in nuclear body. Predicted to be part of VCP-NPL4-UFD1 AAA ATPase complex. Is expressed in several structures, including adrenal gland; gallbladder; genitourinary system; gut gland; and nervous system. Orthologous to human UBXN7 (UBX domain protein 7). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in whole brain E14.5 (RPKM 7.1), CNS E11.5 (RPKM 7.0) and 25 other tissues See more
Orthologs
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Genomic context

See Ubxn7 in Genome Data Viewer
Location:
16 B2- B3; 16 22.58 cM
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (32151023..32212568)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (32332200..32393747)

Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene ring finger protein 168 Neighboring gene STARR-seq mESC enhancer starr_40655 Neighboring gene STARR-positive B cell enhancer mm9_chr16:32332099-32332400 Neighboring gene predicted gene 8387 Neighboring gene transmembrane 4 L six family member 19 Neighboring gene predicted gene, 20056 Neighboring gene STARR-positive B cell enhancer ABC_E8997 Neighboring gene predicted gene, 53948 Neighboring gene dynein light chain Tctex-type 2B

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • KIAA0794

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA polymerase II-specific DNA-binding transcription factor binding ISO
Inferred from Sequence Orthology
more info
 
enables ubiquitin binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables ubiquitin binding ISO
Inferred from Sequence Orthology
more info
 
enables ubiquitin protein ligase binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
part_of VCP-NPL4-UFD1 AAA ATPase complex ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
UBX domain-containing protein 7
Names
UBX domain containing 7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001405897.1NP_001392826.1  UBX domain-containing protein 7 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC087556, AEKQ02018232
    UniProtKB/Swiss-Prot
    Q6P5G6, Q6ZQ44
    UniProtKB/TrEMBL
    Q3UGV7
    Related
    ENSMUSP00000156376.2, ENSMUST00000232137.2
  2. NM_177633.5NP_808301.3  UBX domain-containing protein 7 isoform 1

    See identical proteins and their annotated locations for NP_808301.3

    Status: VALIDATED

    Source sequence(s)
    AC087556, AEKQ02018232
    Consensus CDS
    CCDS49826.1
    UniProtKB/TrEMBL
    G5E8R8, Q3UGV7
    Related
    ENSMUSP00000110804.4, ENSMUST00000115151.5
    Conserved Domains (3) summary
    cd01773
    Location:408489
    Faf1_like1_UBX; Faf1 ike-1 UBX domain
    cd02958
    Location:149261
    UAS; UAS family; UAS is a domain of unknown function. Most members of this family are uncharacterized proteins with similarity to FAS-associated factor 1 (FAF1) and ETEA because of the presence of a UAS domain N-terminal to a ubiquitin-associated UBX domain. ...
    cd14345
    Location:1651
    UBA_UBXD7; UBA-like domain found in UBX domain-containing protein 7 (UBXD7) and similar proteins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000082.7 Reference GRCm39 C57BL/6J

    Range
    32151023..32212568
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036159898.1XP_036015791.1  UBX domain-containing protein 7 isoform X4

    Conserved Domains (2) summary
    cd02958
    Location:127239
    UAS; UAS family; UAS is a domain of unknown function. Most members of this family are uncharacterized proteins with similarity to FAS-associated factor 1 (FAF1) and ETEA because of the presence of a UAS domain N-terminal to a ubiquitin-associated UBX domain. ...
    cd14345
    Location:1651
    UBA_UBXD7; UBA-like domain found in UBX domain-containing protein 7 (UBXD7) and similar proteins
  2. XM_011245880.4XP_011244182.1  UBX domain-containing protein 7 isoform X3

    Conserved Domains (2) summary
    cd02958
    Location:149261
    UAS; UAS family; UAS is a domain of unknown function. Most members of this family are uncharacterized proteins with similarity to FAS-associated factor 1 (FAF1) and ETEA because of the presence of a UAS domain N-terminal to a ubiquitin-associated UBX domain. ...
    cd14345
    Location:1651
    UBA_UBXD7; UBA-like domain found in UBX domain-containing protein 7 (UBXD7) and similar proteins
  3. XM_036159897.1XP_036015790.1  UBX domain-containing protein 7 isoform X2

    UniProtKB/TrEMBL
    Q3UGV7
    Conserved Domains (3) summary
    cd02958
    Location:94206
    UAS; UAS family; UAS is a domain of unknown function. Most members of this family are uncharacterized proteins with similarity to FAS-associated factor 1 (FAF1) and ETEA because of the presence of a UAS domain N-terminal to a ubiquitin-associated UBX domain. ...
    cd01773
    Location:357432
    UBX_UBXN7; Ubiquitin regulatory domain X (UBX) found in UBX domain protein 7 (UBXN7) and similar proteins
    cl21463
    Location:118
    UBA_like_SF; UBA domain-like superfamily