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Lsg1 large 60S subunit nuclear export GTPase 1 [ Mus musculus (house mouse) ]

Gene ID: 224092, updated on 5-Mar-2024

Summary

Official Symbol
Lsg1provided by MGI
Official Full Name
large 60S subunit nuclear export GTPase 1provided by MGI
Primary source
MGI:MGI:107236
See related
Ensembl:ENSMUSG00000022538 AllianceGenome:MGI:107236
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
5830465I20; D16Bwg1547e
Summary
Predicted to enable GTP binding activity and GTPase activity. Predicted to be involved in ribosomal subunit export from nucleus. Predicted to act upstream of or within protein transport. Predicted to be located in Cajal body and endoplasmic reticulum. Predicted to be active in cytosol. Orthologous to human LSG1 (large 60S subunit nuclear export GTPase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 13.9), limb E14.5 (RPKM 8.4) and 28 other tissues See more
Orthologs
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Genomic context

See Lsg1 in Genome Data Viewer
Location:
16 B2; 16 21.34 cM
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (30380187..30406430, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (30561369..30587612, complement)

Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene ATPase type 13A3 Neighboring gene STARR-positive B cell enhancer mm9_chr16:30374407-30374708 Neighboring gene CapStarr-seq enhancer MGSCv37_chr16:30389389-30389616 Neighboring gene STARR-seq mESC enhancer starr_40576 Neighboring gene STARR-seq mESC enhancer starr_40579 Neighboring gene STARR-seq mESC enhancer starr_40580 Neighboring gene transmembrane protein 44 Neighboring gene predicted gene, 52252 Neighboring gene STARR-seq mESC enhancer starr_40581 Neighboring gene STARR-seq mESC enhancer starr_40582 Neighboring gene CapStarr-seq enhancer MGSCv37_chr16:30587870-30588053 Neighboring gene predicted gene, 53946 Neighboring gene STARR-positive B cell enhancer ABC_E5536 Neighboring gene family with sequence similarity 43, member A Neighboring gene STARR-seq mESC enhancer starr_40586 Neighboring gene STARR-positive B cell enhancer ABC_E9928 Neighboring gene predicted gene, 49754

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables GTP binding ISO
Inferred from Sequence Orthology
more info
 
enables GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables GTPase activity ISO
Inferred from Sequence Orthology
more info
 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in nuclear export ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within protein transport IEA
Inferred from Electronic Annotation
more info
 
involved_in ribosomal subunit export from nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
located_in Cajal body ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
located_in nuclear body ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
large subunit GTPase 1 homolog
NP_001403957.1
NP_001403958.1
NP_001403959.1
NP_001403960.1
NP_835170.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001417028.1NP_001403957.1  large subunit GTPase 1 homolog isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC104885
  2. NM_001417029.1NP_001403958.1  large subunit GTPase 1 homolog isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC104885
  3. NM_001417030.1NP_001403959.1  large subunit GTPase 1 homolog isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC104885
  4. NM_001417031.1NP_001403960.1  large subunit GTPase 1 homolog isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC104885
  5. NM_178069.6NP_835170.1  large subunit GTPase 1 homolog isoform 1

    See identical proteins and their annotated locations for NP_835170.1

    Status: VALIDATED

    Source sequence(s)
    AC104885
    Consensus CDS
    CCDS37311.1
    UniProtKB/Swiss-Prot
    Q3UM18, Q68ED9, Q80V36
    Related
    ENSMUSP00000112860.3, ENSMUST00000117363.9
    Conserved Domains (2) summary
    cd01857
    Location:163430
    HSR1_MMR1; A circularly permuted subfamily of the Ras GTPases
    COG1161
    Location:151540
    RbgA; Ribosome biogenesis GTPase A [Translation, ribosomal structure and biogenesis]

RNA

  1. NR_184411.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC104885
  2. NR_184412.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC104885
  3. NR_184413.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC104885
  4. NR_184414.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC104885
  5. NR_184415.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC104885
    Related
    ENSMUST00000143170.9

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000082.7 Reference GRCm39 C57BL/6J

    Range
    30380187..30406430 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_004939187.1 RNA Sequence