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Eif2b5 eukaryotic translation initiation factor 2B, subunit 5 epsilon [ Mus musculus (house mouse) ]

Gene ID: 224045, updated on 21-Apr-2024

Summary

Official Symbol
Eif2b5provided by MGI
Official Full Name
eukaryotic translation initiation factor 2B, subunit 5 epsilonprovided by MGI
Primary source
MGI:MGI:2446176
See related
Ensembl:ENSMUSG00000003235 AllianceGenome:MGI:2446176
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Predicted to enable guanyl-nucleotide exchange factor activity; translation initiation factor activity; and translation initiation factor binding activity. Predicted to be involved in several processes, including T cell receptor signaling pathway; glial cell development; and translational initiation. Predicted to act upstream of or within translation. Located in cytoplasm and nucleus. Is expressed in central nervous system and retina. Used to study leukoencephalopathy with vanishing white matter. Human ortholog(s) of this gene implicated in leukoencephalopathy with vanishing white matter. Orthologous to human EIF2B5 (eukaryotic translation initiation factor 2B subunit epsilon). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 21.4), placenta adult (RPKM 18.0) and 28 other tissues See more
Orthologs
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Genomic context

Location:
16 A3; 16 12.45 cM
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (20317544..20328073)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (20498795..20509325)

Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene ATP-binding cassette, sub-family C member 5 Neighboring gene STARR-seq mESC enhancer starr_40320 Neighboring gene STARR-seq mESC enhancer starr_40322 Neighboring gene STARR-seq mESC enhancer starr_40323 Neighboring gene predicted gene, 41432 Neighboring gene STARR-seq mESC enhancer starr_40326 Neighboring gene STARR-seq mESC enhancer starr_40327 Neighboring gene STARR-seq mESC enhancer starr_40328 Neighboring gene predicted gene, 16618 Neighboring gene STARR-positive B cell enhancer ABC_E1488 Neighboring gene dishevelled segment polarity protein 3 Neighboring gene adaptor-related protein complex 2, mu 1 subunit

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables guanyl-nucleotide exchange factor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
contributes_to guanyl-nucleotide exchange factor activity ISO
Inferred from Sequence Orthology
more info
 
enables guanyl-nucleotide exchange factor activity ISO
Inferred from Sequence Orthology
more info
 
enables guanyl-nucleotide exchange factor activity ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
enables translation initiation factor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
contributes_to translation initiation factor activity ISO
Inferred from Sequence Orthology
more info
 
enables translation initiation factor binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables translation initiation factor binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in T cell receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in astrocyte development ISO
Inferred from Sequence Orthology
more info
 
involved_in astrocyte differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in cytoplasmic translational initiation ISO
Inferred from Sequence Orthology
more info
 
involved_in cytoplasmic translational initiation ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
involved_in myelination ISO
Inferred from Sequence Orthology
more info
 
involved_in oligodendrocyte development ISO
Inferred from Sequence Orthology
more info
 
involved_in ovarian follicle development ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of translation ISO
Inferred from Sequence Orthology
more info
 
involved_in response to endoplasmic reticulum stress ISO
Inferred from Sequence Orthology
more info
 
involved_in response to glucose ISO
Inferred from Sequence Orthology
more info
 
involved_in response to heat ISO
Inferred from Sequence Orthology
more info
 
involved_in response to peptide hormone ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within translation IEA
Inferred from Electronic Annotation
more info
 
involved_in translational initiation ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
part_of eukaryotic translation initiation factor 2B complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of eukaryotic translation initiation factor 2B complex ISO
Inferred from Sequence Orthology
more info
 
part_of eukaryotic translation initiation factor 2B complex ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
translation initiation factor eIF2B subunit epsilon
Names
eIF-2B GDP-GTP exchange factor subunit epsilon
eIF2B GDP-GTP exchange factor subunit epsilon
translation initiation factor eIF-2B subunit epsilon

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001417002.1NP_001403931.1  translation initiation factor eIF2B subunit epsilon isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC161756
  2. NM_001417003.1NP_001403932.1  translation initiation factor eIF2B subunit epsilon isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC161756
  3. NM_001417004.1NP_001403933.1  translation initiation factor eIF2B subunit epsilon isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC161756
  4. NM_001417005.1NP_001403934.1  translation initiation factor eIF2B subunit epsilon isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC161756
  5. NM_172265.3NP_758469.1  translation initiation factor eIF2B subunit epsilon isoform 1

    See identical proteins and their annotated locations for NP_758469.1

    Status: VALIDATED

    Source sequence(s)
    AC161756
    Consensus CDS
    CCDS28047.1
    UniProtKB/Swiss-Prot
    Q3TU39, Q8CHW4
    Related
    ENSMUSP00000003320.7, ENSMUST00000003320.14
    Conserved Domains (4) summary
    cd05787
    Location:357435
    LbH_eIF2B_epsilon; eIF-2B epsilon subunit, central Left-handed parallel beta-Helix (LbH) domain: eIF-2B is a eukaryotic translation initiator, a guanine nucleotide exchange factor (GEF) composed of five different subunits (alpha, beta, gamma, delta and epsilon). eIF2B is ...
    cd04197
    Location:39253
    eIF-2B_epsilon_N; The N-terminal domain of epsilon subunit of the eIF-2B is a subfamily of glycosyltransferase 2
    cd11558
    Location:544707
    W2_eIF2B_epsilon; C-terminal W2 domain of eukaryotic translation initiation factor 2B epsilon
    COG1044
    Location:296406
    LpxD; UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase [Cell wall/membrane/envelope biogenesis]

RNA

  1. NR_184408.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC161756
  2. NR_184409.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC161756
  3. NR_184410.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC161756

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000082.7 Reference GRCm39 C57BL/6J

    Range
    20317544..20328073
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_004939183.1 RNA Sequence