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Ccn5 cellular communication network factor 5 [ Mus musculus (house mouse) ]

Gene ID: 22403, updated on 5-Jan-2023

Summary

Official Symbol
Ccn5provided by MGI
Official Full Name
cellular communication network factor 5provided by MGI
Primary source
MGI:MGI:1328326
See related
Ensembl:ENSMUSG00000027656 AllianceGenome:MGI:1328326
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Crgr4; Ctgfl; Rcop1; Wisp2
Summary
Predicted to enable growth factor activity; heparin binding activity; and integrin binding activity. Acts upstream of or within regulation of cell growth. Located in extracellular space; nucleus; and plasma membrane. Is expressed in several structures, including early conceptus; embryo endoderm; embryo mesoderm; gut; and reproductive system. Orthologous to human CCN5 (cellular communication network factor 5). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in lung adult (RPKM 28.7), ovary adult (RPKM 25.3) and 6 other tissues See more
Orthologs
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Genomic context

See Ccn5 in Genome Data Viewer
Location:
2; 2 H3
Exon count:
6
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (163662724..163675066)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (163820752..163833146)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene adenosine deaminase intronic regulatory elements Neighboring gene adenosine deaminase Neighboring gene adenosine deaminase upstream regulatory elements Neighboring gene potassium channel, subfamily K, member 15 Neighboring gene regulating synaptic membrane exocytosis 4

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 
  • Endonuclease-mediated (1) 

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables growth factor activity ISA
Inferred from Sequence Alignment
more info
PubMed 
enables heparin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables integrin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables integrin binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in cell adhesion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in negative regulation of cell death IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in negative regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of cell growth IDA
Inferred from Direct Assay
more info
PubMed 
involved_in signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in cell surface ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in extracellular matrix IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 
located_in extracellular space HDA PubMed 
located_in extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in podosome ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
CCN family member 5
Names
CTGF-L
WISP-2
WNT1 inducible signaling pathway protein 2
connective tissue growth factor-like protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_016873.2NP_058569.2  CCN family member 5 precursor

    See identical proteins and their annotated locations for NP_058569.2

    Status: VALIDATED

    Source sequence(s)
    AL731698, BC032877, BQ560868
    Consensus CDS
    CCDS17016.1
    UniProtKB/Swiss-Prot
    Q9Z0G4
    UniProtKB/TrEMBL
    A2AHD1
    Related
    ENSMUSP00000029188.8, ENSMUST00000029188.8
    Conserved Domains (2) summary
    smart00214
    Location:100159
    VWC; von Willebrand factor (vWF) type C domain
    pfam00219
    Location:2678
    IGFBP; Insulin-like growth factor binding protein

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    163662724..163675066
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006499169.4XP_006499232.1  CCN family member 5 isoform X1

    Conserved Domains (2) summary
    cl17735
    Location:100159
    VWC; von Willebrand factor type C domain
    pfam00219
    Location:2678
    IGFBP; Insulin-like growth factor binding protein