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Pi4ka phosphatidylinositol 4-kinase alpha [ Mus musculus (house mouse) ]

Gene ID: 224020, updated on 5-Mar-2024

Summary

Official Symbol
Pi4kaprovided by MGI
Official Full Name
phosphatidylinositol 4-kinase alphaprovided by MGI
Primary source
MGI:MGI:2448506
See related
Ensembl:ENSMUSG00000041720 AllianceGenome:MGI:2448506
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Pik4ca; PI4K-alpha
Summary
Enables 1-phosphatidylinositol 4-kinase activity. Involved in phosphatidylinositol phosphate biosynthetic process. Predicted to be located in Golgi-associated vesicle membrane. Predicted to be active in cytoplasm and plasma membrane. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Orthologous to human PI4KA (phosphatidylinositol 4-kinase alpha). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in cortex adult (RPKM 25.4), frontal lobe adult (RPKM 25.2) and 28 other tissues See more
Orthologs
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Genomic context

See Pi4ka in Genome Data Viewer
Location:
16 A3; 16 10.71 cM
Exon count:
57
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (17098215..17224178, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (17280351..17406314, complement)

Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E7430 Neighboring gene hypermethylated in cancer 2 Neighboring gene CapStarr-seq enhancer MGSCv37_chr16:17276268-17276485 Neighboring gene transmembrane protein 191 Neighboring gene serine (or cysteine) peptidase inhibitor, clade D, member 1 Neighboring gene STARR-seq mESC enhancer starr_40252 Neighboring gene predicted gene, 24927 Neighboring gene poly(A) binding protein, cytoplasmic 1 pseudogene Neighboring gene synaptosomal-associated protein 29 Neighboring gene STARR-positive B cell enhancer ABC_E4158 Neighboring gene STARR-seq mESC enhancer starr_40255 Neighboring gene v-crk avian sarcoma virus CT10 oncogene homolog-like Neighboring gene apoptosis-inducing factor, mitochondrion-associated 3

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (2) 
  • Targeted (8)  1 citation
  • Chemically induced (ENU) (2) 
  • Endonuclease-mediated (2) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 1-phosphatidylinositol 4-kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables 1-phosphatidylinositol 4-kinase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables 1-phosphatidylinositol 4-kinase activity ISO
Inferred from Sequence Orthology
more info
 
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables kinase activity ISO
Inferred from Sequence Orthology
more info
PubMed 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in Golgi-associated vesicle membrane ISO
Inferred from Sequence Orthology
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
phosphatidylinositol 4-kinase alpha
Names
PI4-kinase alpha
phosphatidylinositol 4-kinase, catalytic, alpha polypeptide
ptdIns-4-kinase alpha
NP_001001983.2
NP_001360884.1
XP_006522099.1
XP_006522100.1
XP_030104929.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001001983.3NP_001001983.2  phosphatidylinositol 4-kinase alpha isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC110573
    Consensus CDS
    CCDS37271.1
    UniProtKB/TrEMBL
    A0A140T8I9
    Related
    ENSMUSP00000036162.6, ENSMUST00000036161.12
    Conserved Domains (2) summary
    cd00871
    Location:14891664
    PI4Ka; Phosphoinositide 4-kinase(PI4K), accessory domain (PIK domain); PIK domain is conserved in PI3 and PI4-kinases. Its role is unclear but it has been suggested to be involved in substrate presentation. PI4K phosphorylates hydroxylgroup at position 4 on the ...
    cd05167
    Location:17252043
    PI4Kc_III_alpha; Catalytic domain of Type III Phosphoinositide 4-kinase alpha
  2. NM_001373955.1NP_001360884.1  phosphatidylinositol 4-kinase alpha isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC110573, KY499708
    UniProtKB/Swiss-Prot
    E9Q3L2, Q3UVT5, Q6DIC7, Q7TNG2, Q80Y45
    UniProtKB/TrEMBL
    A0A1S6GWJ7
    Related
    ENSMUSP00000156049.3, ENSMUST00000232232.3
    Conserved Domains (2) summary
    cd00871
    Location:15501725
    PI4Ka; Phosphoinositide 4-kinase(PI4K), accessory domain (PIK domain); PIK domain is conserved in PI3 and PI4-kinases. Its role is unclear but it has been suggested to be involved in substrate presentation. PI4K phosphorylates hydroxylgroup at position 4 on the ...
    cd05167
    Location:17862104
    PI4Kc_III_alpha; Catalytic domain of Type III Phosphoinositide 4-kinase alpha

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000082.7 Reference GRCm39 C57BL/6J

    Range
    17098215..17224178 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030249069.2XP_030104929.1  phosphatidylinositol 4-kinase alpha isoform X1

    Conserved Domains (2) summary
    cd00871
    Location:13811556
    PI4Ka; Phosphoinositide 4-kinase(PI4K), accessory domain (PIK domain); PIK domain is conserved in PI3 and PI4-kinases. Its role is unclear but it has been suggested to be involved in substrate presentation. PI4K phosphorylates hydroxylgroup at position 4 on the ...
    cd05167
    Location:16171935
    PI4Kc_III_alpha; Catalytic domain of Type III Phosphoinositide 4-kinase alpha
  2. XM_006522037.3XP_006522100.1  phosphatidylinositol 4-kinase alpha isoform X3

    Conserved Domains (2) summary
    cd00871
    Location:616791
    PI4Ka; Phosphoinositide 4-kinase(PI4K), accessory domain (PIK domain); PIK domain is conserved in PI3 and PI4-kinases. Its role is unclear but it has been suggested to be involved in substrate presentation. PI4K phosphorylates hydroxylgroup at position 4 on the ...
    cd05167
    Location:8521170
    PI4Kc_III_alpha; Catalytic domain of Type III Phosphoinositide 4-kinase alpha
  3. XM_006522036.5XP_006522099.1  phosphatidylinositol 4-kinase alpha isoform X2