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Spidr scaffolding protein involved in DNA repair [ Mus musculus (house mouse) ]

Gene ID: 224008, updated on 7-May-2024

Summary

Official Symbol
Spidrprovided by MGI
Official Full Name
scaffolding protein involved in DNA repairprovided by MGI
Primary source
MGI:MGI:1924834
See related
Ensembl:ENSMUSG00000041974 AllianceGenome:MGI:1924834
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Kiaa0146; 2310008H04Rik
Summary
Predicted to be involved in several processes, including cellular response to camptothecin; cellular response to hydroxyurea; and regulation of double-strand break repair. Predicted to act upstream of or within DNA recombination and DNA repair. Predicted to be located in nucleus. Predicted to be active in nuclear chromosome and nucleoplasm. Orthologous to human SPIDR (scaffold protein involved in DNA repair). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 4.4), limb E14.5 (RPKM 3.5) and 28 other tissues See more
Orthologs
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Genomic context

See Spidr in Genome Data Viewer
Location:
16 A2; 16 10.09 cM
Exon count:
21
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (15707088..15964715, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (15889224..16146851, complement)

Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr16:15863142-15863251 Neighboring gene STARR-positive B cell enhancer ABC_E5527 Neighboring gene predicted gene, 41425 Neighboring gene mitotic spindle organizing protein 2 Neighboring gene STARR-seq mESC enhancer starr_40217 Neighboring gene 60S ribosomal protein L30-like Neighboring gene CCAAT/enhancer binding protein delta Neighboring gene STARR-seq mESC enhancer starr_40218 Neighboring gene STARR-positive B cell enhancer mm9_chr16:15984736-15985037 Neighboring gene predicted gene 10121 Neighboring gene STARR-seq mESC enhancer starr_40221 Neighboring gene STARR-seq mESC enhancer starr_40222 Neighboring gene folate receptor 1 (adult) pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E9425 Neighboring gene STARR-seq mESC enhancer starr_40224 Neighboring gene ribosomal protein L29, pseudogene 4 Neighboring gene STARR-seq mESC enhancer starr_40225 Neighboring gene cell division cycle associated 7 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (2) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC30630, MGC115787

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
 
Component Evidence Code Pubs
is_active_in nuclear chromosome IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nuclear chromosome ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
DNA repair-scaffolding protein
Names
scaffolding protein involved i DNA repair

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001355731.1NP_001342660.1  DNA repair-scaffolding protein isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC113329, AC154586
    UniProtKB/TrEMBL
    Q3TLL0
    Conserved Domains (2) summary
    pfam14950
    Location:158
    DUF4502; Domain of unknown function (DUF4502)
    pfam14951
    Location:208588
    DUF4503; Domain of unknown function (DUF4503)
  2. NM_146068.4NP_666180.2  DNA repair-scaffolding protein isoform 1

    See identical proteins and their annotated locations for NP_666180.2

    Status: VALIDATED

    Source sequence(s)
    AK044836, AK146053, BC089026
    Consensus CDS
    CCDS27980.1
    UniProtKB/Swiss-Prot
    Q3TCD0, Q5U457, Q6A0B6, Q6IS60, Q811E1, Q8BGX7, Q8BWD6, Q8R305
    Related
    ENSMUSP00000038820.8, ENSMUST00000040248.9
    Conserved Domains (2) summary
    pfam14950
    Location:11390
    DUF4502; Domain of unknown function (DUF4502)
    pfam14951
    Location:540920
    DUF4503; Domain of unknown function (DUF4503)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000082.7 Reference GRCm39 C57BL/6J

    Range
    15707088..15964715 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030249064.1XP_030104924.1  DNA repair-scaffolding protein isoform X2

    Conserved Domains (1) summary
    pfam14951
    Location:1376
    DUF4503; Domain of unknown function (DUF4503)
  2. XM_017316946.3XP_017172435.1  DNA repair-scaffolding protein isoform X1

    UniProtKB/TrEMBL
    Q3TLL0
    Conserved Domains (2) summary
    pfam14950
    Location:181
    DUF4502; Domain of unknown function (DUF4502)
    pfam14951
    Location:231611
    DUF4503; Domain of unknown function (DUF4503)