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Spidr scaffolding protein involved in DNA repair [ Mus musculus (house mouse) ]

Gene ID: 224008, updated on 9-Mar-2023

Summary

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Official Symbol
Spidrprovided by MGI
Official Full Name
scaffolding protein involved in DNA repairprovided by MGI
Primary source
MGI:MGI:1924834
See related
Ensembl:ENSMUSG00000041974 AllianceGenome:MGI:1924834
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Kiaa0146; 2310008H04Rik
Summary
Predicted to be involved in several processes, including cellular response to camptothecin; cellular response to hydroxyurea; and regulation of double-strand break repair. Predicted to act upstream of or within DNA recombination and DNA repair. Predicted to be located in nucleus. Predicted to be active in nuclear chromosome and nucleoplasm. Orthologous to human SPIDR (scaffold protein involved in DNA repair). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 4.4), limb E14.5 (RPKM 3.5) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Spidr in Genome Data Viewer
Location:
16; 16 A2
Exon count:
21
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (15707088..15964715, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (15889224..16146851, complement)

Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene mitotic spindle organizing protein 2 Neighboring gene predicted gene, 41425 Neighboring gene 60S ribosomal protein L30-like Neighboring gene CCAAT/enhancer binding protein (C/EBP), delta Neighboring gene predicted gene 10121 Neighboring gene folate receptor 1 (adult) pseudogene Neighboring gene ribosomal protein L29, pseudogene 4 Neighboring gene cell division cycle associated 7 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Distinct pathways of homologous recombination controlled by the SWS1-SWSAP1-SPIDR complex. Prakash R, et al. Nat Commun, 2021 Jul 12. PMID 34253720, Free PMC Article
  2. Mutagenesis of diploid mammalian genes by gene entrapment. Lin Q, et al. Nucleic Acids Res, 2006. PMID 17062627, Free PMC Article
  3. Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2004 Jun 30. PMID 15368895
  4. Fancd2 in vivo interaction network reveals a non-canonical role in mitochondrial function. Zhang T, et al. Sci Rep, 2017 Apr 5. PMID 28378742, Free PMC Article
  5. The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Koscielny G, et al. Nucleic Acids Res, 2014 Jan. PMID 24194600, Free PMC Article

See all (22) citations in PubMed

See citations in PubMed for homologs of this gene provided by HomoloGene

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Distinct pathways of homologous recombination controlled by the SWS1-SWSAP1-SPIDR complex.
    Title: Distinct pathways of homologous recombination controlled by the SWS1-SWSAP1-SPIDR complex.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 
  • Endonuclease-mediated (2) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC30630, MGC115787

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in DNA damage response ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within DNA recombination IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within DNA repair IEA
Inferred from Electronic Annotation
more info
  
involved_in cellular response to camptothecin ISO
Inferred from Sequence Orthology
more info
  
involved_in cellular response to hydroxyurea ISO
Inferred from Sequence Orthology
more info
  
involved_in cellular response to ionizing radiation ISO
Inferred from Sequence Orthology
more info
  
involved_in double-strand break repair via homologous recombination IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
involved_in double-strand break repair via homologous recombination ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of double-strand break repair ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of protein-containing complex assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of double-strand break repair via homologous recombination ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of establishment of protein localization to chromosome IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
involved_in regulation of establishment of protein localization to chromosome ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in nuclear chromosome IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
located_in nuclear chromosome ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
DNA repair-scaffolding protein
Names
scaffolding protein involved i DNA repair

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001355731.1 → NP_001342660.1  DNA repair-scaffolding protein isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC113329, AC154586
    Conserved Domains (2) summary
    pfam14950
    Location:1 → 58
    DUF4502; Domain of unknown function (DUF4502)
    pfam14951
    Location:208 → 588
    DUF4503; Domain of unknown function (DUF4503)

  2. NM_146068.4 → NP_666180.2  DNA repair-scaffolding protein isoform 1

    See identical proteins and their annotated locations for NP_666180.2

    Status: VALIDATED

    Source sequence(s)
    AK044836, AK146053, BC089026
    Consensus CDS
    CCDS27980.1
    UniProtKB/Swiss-Prot
    Q8BGX7, Q8R305
    Related
    ENSMUSP00000038820.8, ENSMUST00000040248.9
    Conserved Domains (2) summary
    pfam14950
    Location:11 → 390
    DUF4502; Domain of unknown function (DUF4502)
    pfam14951
    Location:540 → 920
    DUF4503; Domain of unknown function (DUF4503)

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000082.7 Reference GRCm39 C57BL/6J

    Range
    15707088..15964715 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030249064.1 → XP_030104924.1  DNA repair-scaffolding protein isoform X2

    Conserved Domains (1) summary
    pfam14951
    Location:1 → 376
    DUF4503; Domain of unknown function (DUF4503)

  2. XM_017316946.3 → XP_017172435.1  DNA repair-scaffolding protein isoform X1

    Conserved Domains (2) summary
    pfam14950
    Location:1 → 81
    DUF4502; Domain of unknown function (DUF4502)
    pfam14951
    Location:231 → 611
    DUF4503; Domain of unknown function (DUF4503)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BGX7.1 GenPept UniProtKB/Swiss-Prot:Q8BGX7

Gene LinkOut

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