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Marf1 meiosis regulator and mRNA stability 1 [ Mus musculus (house mouse) ]

Gene ID: 223989, updated on 12-May-2024

Summary

Official Symbol
Marf1provided by MGI
Official Full Name
meiosis regulator and mRNA stability 1provided by MGI
Primary source
MGI:MGI:2444505
See related
Ensembl:ENSMUSG00000060657 AllianceGenome:MGI:2444505
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Lkap; mKIAA0430; E030019O05; 4921513D23Rik
Summary
Predicted to enable CCR4-NOT complex binding activity and mRNA binding activity involved in posttranscriptional gene silencing. Involved in female meiotic nuclear division; oogenesis; and regulation of gene expression. Acts upstream of or within double-strand break repair. Predicted to be located in Golgi apparatus and peroxisome. Predicted to be active in cytoplasm. Is expressed in central nervous system; early conceptus; oocyte; and sensory organ. Orthologous to human MARF1 (meiosis regulator and mRNA stability factor 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in cortex adult (RPKM 10.6), frontal lobe adult (RPKM 9.7) and 28 other tissues See more
Orthologs
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Genomic context

See Marf1 in Genome Data Viewer
Location:
16 A1; 16 9.69 cM
Exon count:
28
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (13927030..13977157, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (14109166..14159278, complement)

Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene bMERB domain containing 1 Neighboring gene high mobility group nucleosome-binding domain-containing protein 5-like Neighboring gene Y box protein 1 pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E7428 Neighboring gene STARR-positive B cell enhancer ABC_E4155 Neighboring gene microRNA 484 Neighboring gene STARR-seq mESC enhancer starr_40176 Neighboring gene nudE neurodevelopment protein 1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Chemically induced (ENU) (1) 
  • Endonuclease-mediated (2)  1 citation
  • Gene trapped (1) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • KIAA0430, MGC36956

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables CCR4-NOT complex binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables RNA binding IEA
Inferred from Electronic Annotation
more info
 
enables RNA nuclease activity IEA
Inferred from Electronic Annotation
more info
 
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within cell differentiation IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within double-strand break repair IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in female meiotic nuclear division IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within meiotic cell cycle IEA
Inferred from Electronic Annotation
more info
 
involved_in oogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
 
located_in peroxisome ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
meiosis regulator and mRNA stability factor 1
Names
limkain-b1
meiosis arrest female 1
meiosis arrest female protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001081154.2NP_001074623.1  meiosis regulator and mRNA stability factor 1

    Status: VALIDATED

    Source sequence(s)
    AC119853, AC164291
    Consensus CDS
    CCDS37262.1
    UniProtKB/Swiss-Prot
    E9QPE4, Q5DU29, Q8BJ34, Q8C6U4, Q8K2E6
    Related
    ENSMUSP00000087770.5, ENSMUST00000090300.6
    Conserved Domains (10) summary
    cd09978
    Location:10021072
    LOTUS_2_Limkain_b1; The second LOTUS domain on Limkain b1(LKAP)
    cd09979
    Location:10981169
    LOTUS_3_Limkain_b1; The third LOTUS domain on Limkain b1(LKAP)
    cd09980
    Location:11741245
    LOTUS_4_Limkain_b1; The fourth LOTUS domain on Limkain b1(LKAP)
    cd09981
    Location:12581328
    LOTUS_5_Limkain_b1; The fifth LOTUS domain on Limkain b1(LKAP)
    cd09983
    Location:14101482
    LOTUS_7_Limkain_b1; The seventh LOTUS domain on Limkain b1(LKAP)
    cd09984
    Location:14851560
    LOTUS_8_Limkain_b1; The eighth LOTUS domain on Limkain b1(LKAP)
    cd10910
    Location:351493
    limkain_b1_N_like; N-terminal LabA-like domain of limkain b1 and similar proteins
    cd12255
    Location:508580
    RRM1_LKAP; RNA recognition motif 1 in Limkain-b1 (LKAP) and similar proteins
    cd12256
    Location:785873
    RRM2_LKAP; RNA recognition motif 2 in Limkain-b1 (LKAP) and similar proteins
    cl14879
    Location:13341404
    LabA_like_C; C-terminal domain of LabA_like proteins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000082.7 Reference GRCm39 C57BL/6J

    Range
    13927030..13977157 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006522018.4XP_006522081.1  meiosis regulator and mRNA stability factor 1 isoform X1

    UniProtKB/Swiss-Prot
    E9QPE4, Q5DU29, Q8BJ34, Q8C6U4, Q8K2E6
    Conserved Domains (10) summary
    cd09978
    Location:9881058
    LOTUS_2_Limkain_b1; The second LOTUS domain on Limkain b1(LKAP)
    cd09979
    Location:10841155
    LOTUS_3_Limkain_b1; The third LOTUS domain on Limkain b1(LKAP)
    cd09980
    Location:11601231
    LOTUS_4_Limkain_b1; The fourth LOTUS domain on Limkain b1(LKAP)
    cd09981
    Location:12441314
    LOTUS_5_Limkain_b1; The fifth LOTUS domain on Limkain b1(LKAP)
    cd09983
    Location:13961468
    LOTUS_7_Limkain_b1; The seventh LOTUS domain on Limkain b1(LKAP)
    cd09984
    Location:14711546
    LOTUS_8_Limkain_b1; The eighth LOTUS domain on Limkain b1(LKAP)
    cd12255
    Location:508580
    RRM1_LKAP; RNA recognition motif 1 in Limkain-b1 (LKAP) and similar proteins
    cd12256
    Location:771859
    RRM2_LKAP; RNA recognition motif 2 in Limkain-b1 (LKAP) and similar proteins
    cd10910
    Location:351473
    PIN_limkain_b1_N_like; N-terminal LabA-like PIN domain of limkain b1 and similar proteins
    cl14879
    Location:13201390
    LabA_like_C; C-terminal domain of LabA_like proteins
  2. XM_006522019.3XP_006522082.1  meiosis regulator and mRNA stability factor 1 isoform X2

    UniProtKB/Swiss-Prot
    E9QPE4, Q5DU29, Q8BJ34, Q8C6U4, Q8K2E6
    Conserved Domains (10) summary
    cd09978
    Location:10021072
    LOTUS_2_Limkain_b1; The second LOTUS domain on Limkain b1(LKAP)
    cd09979
    Location:10981169
    LOTUS_3_Limkain_b1; The third LOTUS domain on Limkain b1(LKAP)
    cd09980
    Location:11741245
    LOTUS_4_Limkain_b1; The fourth LOTUS domain on Limkain b1(LKAP)
    cd09981
    Location:12581328
    LOTUS_5_Limkain_b1; The fifth LOTUS domain on Limkain b1(LKAP)
    cd09983
    Location:14101482
    LOTUS_7_Limkain_b1; The seventh LOTUS domain on Limkain b1(LKAP)
    cd09984
    Location:14851560
    LOTUS_8_Limkain_b1; The eighth LOTUS domain on Limkain b1(LKAP)
    cd12255
    Location:508580
    RRM1_LKAP; RNA recognition motif 1 in Limkain-b1 (LKAP) and similar proteins
    cd12256
    Location:785873
    RRM2_LKAP; RNA recognition motif 2 in Limkain-b1 (LKAP) and similar proteins
    cd10910
    Location:351473
    PIN_limkain_b1_N_like; N-terminal LabA-like PIN domain of limkain b1 and similar proteins
    cl14879
    Location:13341404
    LabA_like_C; C-terminal domain of LabA_like proteins