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Wfs1 wolframin ER transmembrane glycoprotein [ Mus musculus (house mouse) ]

Gene ID: 22393, updated on 11-Jun-2024

Summary

Official Symbol
Wfs1provided by MGI
Official Full Name
wolframin ER transmembrane glycoproteinprovided by MGI
Primary source
MGI:MGI:1328355
See related
Ensembl:ENSMUSG00000039474 AllianceGenome:MGI:1328355
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
wolframin
Summary
Enables ATPase binding activity. Involved in several processes, including negative regulation of apoptotic process; protein stabilization; and ubiquitin-dependent ERAD pathway. Located in endoplasmic reticulum. Is expressed in several structures, including brain; craniocervical region bone; diaphragm; stomach; and vertebral axis musculature. Used to study Wolfram syndrome 1. Human ortholog(s) of this gene implicated in Wolfram syndrome (multiple); auditory system disease (multiple); cataract 41; diabetes mellitus (multiple); and optic atrophy (multiple). Orthologous to human WFS1 (wolframin ER transmembrane glycoprotein). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in adrenal adult (RPKM 31.3), heart adult (RPKM 27.5) and 24 other tissues See more
Orthologs
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Genomic context

See Wfs1 in Genome Data Viewer
Location:
5 B3; 5 19.46 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (37123448..37146326, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (36966104..36988982, complement)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene protein phosphatase 2, regulatory subunit B, gamma, opposite strand Neighboring gene protein phosphatase 2, regulatory subunit B, gamma Neighboring gene STARR-seq mESC enhancer starr_12887 Neighboring gene STARR-seq mESC enhancer starr_12890 Neighboring gene predicted gene, 52813 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:37370903-37371090 Neighboring gene STARR-positive B cell enhancer ABC_E6324 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:37380607-37380790 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:37389242-37389505 Neighboring gene STARR-seq mESC enhancer starr_12893 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:37436048-37436298 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:37438571-37438789 Neighboring gene janus kinase and microtubule interacting protein 1 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:37442129-37442330 Neighboring gene isocitrate dehydrogenase 3 (NAD+) beta pseudogene Neighboring gene STARR-seq mESC enhancer starr_12898 Neighboring gene predicted gene 1043

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (7) 
  • Targeted (5)  1 citation

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATPase binding IDA
Inferred from Direct Assay
more info
PubMed 
enables ATPase binding ISO
Inferred from Sequence Orthology
more info
 
enables DNA-binding transcription factor binding ISO
Inferred from Sequence Orthology
more info
 
enables calcium-dependent protein binding ISO
Inferred from Sequence Orthology
more info
 
enables calmodulin binding ISO
Inferred from Sequence Orthology
more info
 
enables proteasome binding ISO
Inferred from Sequence Orthology
more info
 
enables ubiquitin protein ligase binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in ERAD pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in ERAD pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in calcium ion homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in calcium ion homeostasis ISO
Inferred from Sequence Orthology
more info
 
involved_in endoplasmic reticulum calcium ion homeostasis ISO
Inferred from Sequence Orthology
more info
 
involved_in endoplasmic reticulum unfolded protein response IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in endoplasmic reticulum unfolded protein response IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in endoplasmic reticulum unfolded protein response TAS
Traceable Author Statement
more info
PubMed 
involved_in glucose homeostasis ISO
Inferred from Sequence Orthology
more info
 
involved_in kidney development ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of ATF6-mediated unfolded protein response ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of neuron apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of programmed cell death ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of response to endoplasmic reticulum stress ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of translation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of translation TAS
Traceable Author Statement
more info
PubMed 
involved_in negative regulation of type B pancreatic cell apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of type B pancreatic cell apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in nervous system process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of ERAD pathway IC
Inferred by Curator
more info
PubMed 
involved_in positive regulation of ERAD pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of ERAD pathway TAS
Traceable Author Statement
more info
PubMed 
involved_in positive regulation of calcium ion transport ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of growth IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of protein metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein ubiquitination IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of protein ubiquitination ISO
Inferred from Sequence Orthology
more info
 
involved_in protein stabilization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein stabilization ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of cell cycle NAS
Non-traceable Author Statement
more info
PubMed 
involved_in renal water homeostasis ISO
Inferred from Sequence Orthology
more info
 
involved_in response to endoplasmic reticulum stress IDA
Inferred from Direct Assay
more info
PubMed 
involved_in response to endoplasmic reticulum stress ISO
Inferred from Sequence Orthology
more info
 
involved_in sensory perception of sound ISO
Inferred from Sequence Orthology
more info
 
involved_in visual perception ISO
Inferred from Sequence Orthology
more info
 
involved_in visual perception NAS
Non-traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
 
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
is_active_in endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in secretory granule ISO
Inferred from Sequence Orthology
more info
 
is_active_in synaptic vesicle membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
wolframin
Names
Wolfram syndrome 1 homolog
Wolfram syndrome 1 protein homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_011716.2NP_035846.1  wolframin

    See identical proteins and their annotated locations for NP_035846.1

    Status: VALIDATED

    Source sequence(s)
    AC115722, AK144561, BY063019, BY296480, CX562372
    Consensus CDS
    CCDS19245.1
    UniProtKB/Swiss-Prot
    P56695, Q9Z276
    UniProtKB/TrEMBL
    Q3TDI2, Q80UI9
    Related
    ENSMUSP00000048053.7, ENSMUST00000043964.13

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    37123448..37146326 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)